Search Result

Results for "

self-assembly

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Linker (2) Amyloid-β (10) Apoptosis (7) Autophagy (2) Bacterial (1) Biochemical Assay Reagents (108) Calcium Channel (1) Caspase (1) Cholinesterase (ChE) (4) Drug Intermediate (2) Endogenous Metabolite (1) Environmental Pollutants (2) Isotope-Labeled Compounds (1) Lipase (1) MDM-2/p53 (2) Microtubule/Tubulin (2) NF-κB (2) PD-1/PD-L1 (1) PERK (2) Photosensitizer (1) PPAR (1) Reactive Oxygen Species (ROS) (1) Reference Standards (2) TMV (3)
By Research Areas:	Cancer (12) Endocrinology (2) Infection (4) Inflammation/Immunology (5) Metabolic Disease (4) Neurological Disease (10)
Click Chemistry:	Azide (3)
Oligonucleotides:	Pegylated Lipids (27) Emulsifiers (1) Solubilizing Agents (1)

136

Inhibitors & Agonists

Screening Libraries

106

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-101064

Fmoc-leucine N-FMOC-leucine; NPC 15199; NSC 334290	PPAR Calcium Channel Lipase	Metabolic Disease Inflammation/Immunology
Fmoc-Leucine (N-FMOC-leucine) is an anti-inflammatory agent that not only promotes extracellular Ca ²⁺ influx but also facilitates intracellular Ca ²⁺ release. Fmoc-Leucine is a selective ligand for PPARγ (K_i = 15 μM), exhibiting insulin-sensitizing effects but with weak fatogenic activity. Fmoc-Leucine exhibits unique self-assembly properties and can form transient gels, stable gels, or crystals/2D sheets through different pathways. Fmoc-Leucine can be used in the research of diabetes, colitis, and bladder cancer .

HY-P1449

Boc-Gly-Gly-Phe-Gly-OH	ADC Linker	Cancer
Boc-Gly-Gly-Phe-Gly-OH, a self-assembly of N- and C-protected tetrapeptide, is a protease cleavable linker used for the antibody-drug conjugate (ADC).

HY-B0949

Protriptyline hydrochloride 2 Publications Verification	Cholinesterase (ChE) Amyloid-β	Neurological Disease
Protriptyline hydrochloride is a potent tricyclic antidepressant (TCA). Protriptyline hydrochloride inhibits AChE activity with an IC₅₀ value of 0.06 mM and inhibits Aβ self-assembly. Protriptyline hydrochloride can be used for the study of depression and Alzheimers disease .

HY-P4808

PHF6	Amyloid-β Autophagy	Neurological Disease
PHF6 (VQIVYK) is a self-assembly sequence capable of initiating the full-length tau protein aggregation and is mapped to the third microtubule-binding repeat region of the tau protein .

HY-154644

Soya Lecithin	Environmental Pollutants Biochemical Assay Reagents	Cancer
Soya Lecithin is a phospholipid mixture that can be used as a drug delivery vehicle and is a pharmaceutical excipient. Soya Lecithin can form a lipid bilayer structure through self-assembly, and its binding properties are amphiphilic (hydrophilic head and hydrophobic tail), encapsulating hydrophobic drugs. Soya Lecithin forms stable nanoliposomes or microemulsions, improves the solubility and cellular uptake efficiency of poorly soluble drugs (such as Curcumin (HY-N0005)), and exerts activities such as enhancing drug delivery and regulating cell proliferation .

HY-N0687

Vindoline 1 Publications Verification	Microtubule/Tubulin Apoptosis NF-κB PERK	Metabolic Disease Inflammation/Immunology Endocrinology
Vindoline is an orally active vinca alkaloid. Vindoline can be extracted from the leaves of Catharanthus roseus. Vindoline has a weak inhibitory effect on the self-assembly of tubulin. Vindoline alleviates Apoptosis, inhibits p-p65 and p-ERK. Vindoline improves diabetes, bone loss, osteoarthritis, and kidney damage .

HY-121447

Heneicosanoic acid	Endogenous Metabolite	Metabolic Disease
Heneicosanoic acid is an odd-chain saturated fatty acid widely present in human milk, fish, seeds, and cerebrosides in the cell membranes of the nervous system. Heneicosanoic acid can form Langmuir monolayers and is often used as a model to study lipid self-assembly and disassembly processes in biological membranes and drug delivery systems. In the low-temperature L'2 and CS crystalline phases, Heneicosanoic acid undergoes local oscillations, which in turn drive the spontaneous formation and expulsion of micelles and vesicles .

HY-145785A

ADH-6 TFA	MDM-2/p53 Apoptosis	Cancer
ADH-6 TFA is a tripyridylamide compound. ADH-6 abrogates self-assembly of the aggregation-nucleating subdomain of mutant p53 DBD. ADH-6 TFA targets and dissociates mutant p53 aggregates in human cancer cells, which restores p53's transcriptional activity, leading to cell cycle arrest and apoptosis. ADH-6 TFA has the potential for the research of cancer diseases .

HY-W440702

Cholesterol-PEG2000-NHS	Biochemical Assay Reagents	Others
Cholesterol-PEG2000-NHS is a cholesterol PEG derivative that can form micelles through molecular self-assembly and has a longer half-life in vivo. Cholesterol-PEG2000-NHS can be used in drug delivery research .

HY-P4637

Ile-Phe H-Ile-Phe-OH	Amyloid-β	Others
Ile-Phe is a dipeptide that self-associates in aqueous solution to form a transparent thermoreversible gel formed by a network of fibrillar nanostructures. It may be involved in triggering self-assembly processes such as amyloid formation.

HY-P4808A

PHF6 TFA	Amyloid-β Autophagy	Neurological Disease
PHF6 (VQIVYK) TFA is a self-assembly sequence capable of initiating the full-length tau protein aggregation. PHF6 TFA is mapped to the third microtubule-binding repeat region of the tau protein .

HY-W440697

Cholesterol-PEG1000-NHS	Biochemical Assay Reagents	Others
Cholesterol-PEG1000-NHS is a cholesterol PEG derivative that can form micelles through molecular self-assembly and has a longer half-life in vivo. Cholesterol-PEG1000-NHS can be used in drug delivery research .

HY-158189

TPP-Ce6	Photosensitizer Reactive Oxygen Species (ROS) Apoptosis	Neurological Disease Cancer
TPP-Ce6 is a mitochondria-targeted photosensitizer formed by the ester bond conjugation of chlorophyll e6 (Ce6) with triphenylphosphine (TPP). Under light irradiation or ultrasound exposure, TPP-Ce6 generates reactive oxygen species, induces cell apoptosis, and triggers immunogenic cell death. TPP-Ce6 can serve as a component of carrier-free co-delivery systems, undergo enzyme-induced self-assembly within tumors, and modulate tumor hypoxia. TPP-Ce6 is applicable to research on breast cancer and glioblastoma .

HY-P5681

Human α-Defensin 6	Bacterial	Infection Inflammation/Immunology
Human α-Defensin 6, a 32-residue cysteine-rich peptide, can inhibit bacterial invasion and contribute to the mucosal immunity. Human α-Defensin 6 forms ordered self-assembly fibrils and nanonets that surround and entangle bacteria after stochastic binding to bacterial surface proteins. Human α-Defensin 6 also inhibits C. albicans biofilm formation .

HY-W099571

Lithium stearate Maximum Cited Publications 22 Publications Verification Stearic acid lithium; Lithium octadecanoate	Environmental Pollutants Biochemical Assay Reagents	Others
Lithium stearate (Stearic acid (lithium)) is a compound that forms vesicles in reaction with silver nitrate, thereby changing the reaction kinetics of the nucleation and self-assembly process of silver stearate. It has the activity that even in the presence of excess silver nitrate, only about 80% can be converted into silver stearate and the residual lithium stearate will inhibit the growth process of silver stearate crystals, thereby producing silver stearate crystals that are much smaller than those obtained from sodium stearate, providing an opportunity to further control the self-assembly and crystal growth of silver stearate.

HY-W000933

Ethylboronic acid	Drug Intermediate	Others
Ethylboronic acid is an organic boron compound that can be used as a synthetic intermediate .

HY-P1449A

Boc-Gly-Gly-Phe-Gly-OH TFA	ADC Linker	Cancer
Boc-Gly-Gly-Phe-Gly-OH TFA, a self-assembly of N- and C-protected tetrapeptide, is a protease cleavable linker used for the antibody-drug conjugate (ADC).

HY-145785

ADH-6	MDM-2/p53 Apoptosis	Cancer
ADH-6 is a tripyridylamide compound. ADH-6 abrogates self-assembly of the aggregation-nucleating subdomain of mutant p53 DBD. ADH-6 targets and dissociates mutant p53 aggregates in human cancer cells, which restores p53's transcriptional activity, leading to cell cycle arrest and apoptosis. ADH-6 has the potential for the research of cancer diseases[1].

HY-178106

SCN2	Drug Intermediate	Cancer
SCN2 is a esterase-responsive prodrug-based amphiphile composed of SN38 (HY-13704) and di-(triazole-[12]aneN3, N) moiety through a 7‑carbon alkyl chains. SCN2 has excellent self-assembly and reversible siRNA condensation capabilities as well as anti-proliferation activity against cancer cells. SCN2 can be used for synthesis of nanoparticles for drug delivery of lung cancer .

HY-149764

Aβ42 agonist-2	Amyloid-β	Neurological Disease
Aβ42 agonist-2 (compound 7b) is a small molecule compound that can promote Aβ42 aggregation. Aβ42 agonist-2 can interact with Aβ42 oligomers and pentamers to promote nontoxic aggregate self-assembly and rapid fibril formation. Aβ42 agonist-2 prevents Aβ42-induced cytotoxicity in HT22 hippocampal neuronal cells .

HY-P10701

Q11 peptide	Biochemical Assay Reagents	Inflammation/Immunology Cancer
Q11 peptide is a β-sheet-forming peptide that plays an important role in self-assembly and targeted applications. As a scaffold peptide, Q11 peptide can display immunogenic epitopes and is widely used in peptide-based immune vaccine research. Additionally, Q11 peptide can be conjugated with MUC1 glycopeptides for the study of self-assembling, adjuvant-free MUC1 glycopeptide vaccines. Q11 peptide holds great potential for research in the field of cancer immunology .

HY-B0949A

Protriptyline	Cholinesterase (ChE) Amyloid-β	Neurological Disease
Protriptyline is a potent tricyclic antidepressant (TCA). Protriptyline inhibits AChE activity with an IC₅₀ value of 0.06 mM and inhibits Aβ self-assembly. Protriptyline can be used for the study of depression and Alzheimers disease .

HY-P10494

FEFEFKFK	Amyloid-β	Neurological Disease
FEFEFKFK is an octapeptide that self-assembles into fibrillar structures. FEFEFKFK is able to form gels at concentrations greater than about 7 mg/mL. The self-assembly and gelation properties of FEFEFKFK help to understand the mechanism of amyloid fibril formation in protein misfolding diseases such as Alzheimer's disease and Parkinson's disease .

HY-N0687R

Vindoline (Standard)	Reference Standards Microtubule/Tubulin Apoptosis NF-κB PERK	Metabolic Disease Inflammation/Immunology Endocrinology
Vindoline (Standard) is an analytical standard of Vindoline (HY-N0687). This product is intended for research and analytical applications. Vindoline is an orally active vinca alkaloid. Vindoline can be extracted from the leaves of Catharanthus roseus. Vindoline has a weak inhibitory effect on the self-assembly of tubulin. Vindoline alleviates Apoptosis, inhibits p-p65 and p-ERK. Vindoline improves diabetes, bone loss, osteoarthritis, and kidney damage .

HY-W440718

Cholesterol-PEG1000-Mal	Biochemical Assay Reagents	Others
Cholesterol-PEG1000-Mal is a cholesterol PEG derivative that can form micelles through molecular self-assembly and has a longer half-life in vivo. Cholesterol-PEG1000-Mal can be used in drug delivery research .

HY-W440704

Cholesterol-PEG5000-NHS	Biochemical Assay Reagents	Others
Cholesterol-PEG5000-NHS is a cholesterol PEG derivative that can form micelles through molecular self-assembly and has a longer half-life in vivo. Cholesterol-PEG5000-NHS can be used in drug delivery research .

HY-167006

PLGA10000-PEG3000-VS PLGA10000-PEG3000-Vinylsulfone	Biochemical Assay Reagents	Others
PLGA10000-PEG3000-VS (PLGA10000-PEG3000-Vinylsulfone) is an amphiphilic polymer. Amphiphilic polymers can be used in drug delivery studies due to their ability to self-assemble into discrete aggregates .

HY-163201

TMV-IN-7	TMV	Infection
TMV-IN-7 (compound G2) is a potent inhibitor of tobacco mosaic virus (TMV). TMV-IN-7 exhibits strong hydrophobic interactions to obstructing the virus’s self-assembly .

HY-W591891

Cholesterol-PEG1000-acid	Biochemical Assay Reagents	Others
Cholesterol-PEG1000-acid is a cholesterol PEG derivative that can form micelles through molecular self-assembly and has a longer half-life in vivo. Cholesterol-PEG1000-acid can be used in drug delivery research .

HY-154971

Ara-SH	Apoptosis	Cancer
Ara-SH is a Cytarabine mercaptopropionic acid-substituted derivative. Ara-SH is used as the trigger to fabricate a smart Cytarabine and Venetoclax-coloaded nanoparticle (AV-NP) through self-assembly. Ara-SH exhibits remarkable synergistic antileukemia effects in vitro and in vivo .

HY-W440695

Cholesterol-PEG3400-azide	Biochemical Assay Reagents	Others
Cholesterol-PEG3400-azide is a cholesterol PEG derivative that can form micelles through molecular self-assembly and has a longer half-life in vivo. Cholesterol-PEG3400-azide can be used in drug delivery research .

HY-W440692

Cholesterol-PEG5000-amine	Biochemical Assay Reagents	Others
Cholesterol-PEG5000-amine is a cholesterol PEG derivative that can form micelles through molecular self-assembly and has a longer half-life in vivo. Cholesterol-PEG5000-amine can be used in drug delivery research .

HY-W440696

Cholesterol-PEG5000-azide	Biochemical Assay Reagents	Others
Cholesterol-PEG5000-azide is a cholesterol PEG derivative that can form micelles through molecular self-assembly and has a longer half-life in vivo. Cholesterol-PEG5000-azide can be used in drug delivery research .

HY-W591912

Cholesterol-PEG1000-methoxy	Biochemical Assay Reagents	Others
Cholesterol-PEG1000-methoxy is a cholesterol PEG derivative that can form micelles through molecular self-assembly and has a longer half-life in vivo. Cholesterol-PEG1000-methoxy can be used in drug delivery research .

HY-W440723

Cholesterol-PEG2000-Thiol	Biochemical Assay Reagents	Others
Cholesterol-PEG2000-Thiol is a cholesterol PEG derivative that can form micelles through molecular self-assembly and has a longer half-life in vivo. Cholesterol-PEG2000-Thiol can be used in drug delivery research .

HY-W440707

Cholesterol-PEG3400-alcohol	Biochemical Assay Reagents	Others
Cholesterol-PEG3400-alcohol is a cholesterol PEG derivative that can form micelles through molecular self-assembly and has a longer half-life in vivo. Cholesterol-PEG3400-alcohol can be used in drug delivery research .

HY-W440721

Cholesterol-PEG5000-Mal	Biochemical Assay Reagents	Others
Cholesterol-PEG5000-Mal is a cholesterol PEG derivative that can form micelles through molecular self-assembly and has a longer half-life in vivo. Cholesterol-PEG5000-Mal can be used in drug delivery research .

HY-W440693

Cholesterol-PEG1000-azide	Biochemical Assay Reagents	Others
Cholesterol-PEG1000-azide is a cholesterol PEG derivative that can form micelles through molecular self-assembly and has a longer half-life in vivo. Cholesterol-PEG1000-azide can be used in drug delivery research .

HY-W440691

Cholesterol-PEG3400-amine	Biochemical Assay Reagents	Others
Cholesterol-PEG3400-amine is a cholesterol PEG derivative that can form micelles through molecular self-assembly and has a longer half-life in vivo. Cholesterol-PEG3400-amine can be used in drug delivery research .

HY-W440705

Cholesterol-PEG1000-alcohol	Biochemical Assay Reagents	Others
Cholesterol-PEG1000-alcohol is a cholesterol PEG derivative that can form micelles through molecular self-assembly and has a longer half-life in vivo. Cholesterol-PEG1000-alcohol can be used in drug delivery research .

HY-W440720

Cholesterol-PEG3400-Mal	Biochemical Assay Reagents	Others
Cholesterol-PEG3400-Mal is a cholesterol PEG derivative that can form micelles through molecular self-assembly and has a longer half-life in vivo. Cholesterol-PEG3400-Mal can be used in drug delivery research .

HY-W440708

Cholesterol-PEG5000-alcohol	Biochemical Assay Reagents	Others
Cholesterol-PEG5000-alcohol is a cholesterol PEG derivative that can form micelles through molecular self-assembly and has a longer half-life in vivo. Cholesterol-PEG5000-alcohol can be used in drug delivery research .

HY-W440703

Cholesterol-PEG3400-NHS	Biochemical Assay Reagents	Others
Cholesterol-PEG3400-NHS is a cholesterol PEG derivative that can form micelles through molecular self-assembly and has a longer half-life in vivo. Cholesterol-PEG3400-NHS can be used in drug delivery research .

HY-W440712

Cholesterol-PEG3400-Biotin	Biochemical Assay Reagents	Others
Cholesterol-PEG3400-Biotin is a cholesterol PEG derivative that can form micelles through molecular self-assembly and has a longer half-life in vivo. Cholesterol-PEG3400-Biotin can be used in drug delivery research .

HY-W751932

Carboxy-EG6-undecanethiol	Biochemical Assay Reagents	Others
Carboxy-EG6-undecanethiol is an alkanethiol that suitable for self-assembly a gold thin-film substrate. Carboxy-EG6-undecanethiol can selectively capture HbA1c in sample by covalent coupling of 3-aminophenyl boronic acid (3-APBA) .

HY-B0949AS

Protriptyline-d3	Cholinesterase (ChE) Isotope-Labeled Compounds Amyloid-β	Neurological Disease
Protriptyline-d₃ is deuterium labeled Protriptyline (HY-B0949). Protriptyline is a potent tricyclic antidepressant (TCA). Protriptyline inhibits AChE activity with an IC₅₀ value of 0.06 mM and inhibits Aβ self-assembly. Protriptyline can be used for the study of depression and Alzheimers disease .

HY-163999

TMV-IN-12	TMV	Infection
TMV-IN-12 (compound 4) is an inhibitor of tobacco mosaic virus (TMV) with antifungal properties. TMV-IN-12 effectively prevents TMV particle aggregation and self-assembly of TMV capsid protein (TMV-CP) (Kd=0.142 μM), preventing TMV from infecting tobacco plants .

HY-B0949R

Protriptyline hydrochloride (Standard)	Reference Standards Cholinesterase (ChE) Amyloid-β	Neurological Disease
Protriptyline hydrochloride (Standard) is the analytical standard of Protriptyline hydrochloride (HY-B0949). This product is intended for research and analytical applications. Protriptyline hydrochloride is a potent tricyclic antidepressant (TCA). Protriptyline hydrochloride inhibits AChE activity with an IC₅₀ value of 0.06 mM and inhibits Aβ self-assembly. Protriptyline hydrochloride can be used for the study of depression and Alzheimers disease .

HY-169434

LTB Lon-TK-BMS-1	PD-1/PD-L1	Cancer
LTB is a prodrug formed by coupling glycolysis inhibitor (Lonidamine (HY-B0486)) with PD1/PDL1 blocker (BMS-1 (HY-19991)) by thioketal linkage. LTB can further encapsulate photosensitizer chlorine e6 (Ce6) (HY-13594) to construct a co-delivery photodynamic nanoplatform (LTB-6 NPs) by self-assembly .

HY-149763

Aβ42 agonist-1	Amyloid-β	Neurological Disease
Aβ42 agonist-1 is a compound that can promote Aβ42 aggregation. Aβ42 agonist-1 can interact with Aβ42 oligomers and pentamers to promote nontoxic aggregate self-assembly and rapid fibril formation. Aβ42 agonist-1 prevents Aβ42-induced cytotoxicity in HT22 hippocampal neuronal cells .

Cat. No.	Product Name

HY-L214

Liposome Library

192 compounds

Liposomes are spherical or multilayered spherical vesicles formed by the self-assembly of diacyl chain phospholipids (lipid bilayers) in aqueous solutions, which can be made from natural or synthetic phospholipids and exhibit good biocompatibility and low toxicity. They can serve as delivery carriers for various bioactive substances (such as drugs, proteins, nucleic acids, etc.) and are widely used in biomedical and chemical research. The main advantages of liposomes include 1) Protective effect: Their bilayer structure can protect encapsulated molecules from enzymatic degradation, oxidation, and other influences, extending stability and activity; 2) Active targeting: Surface modifications enable active targeting, enhancing the concentration of drugs or molecules in specific tissues or cells; 3) Customizability: The composition and structure of liposomes can be adjusted according to needs, such as altering phospholipid types or adding targeting ligands. These properties make liposomes highly valuable in developing novel drug delivery systems, serving as nucleic acid carriers for gene transfection, studying cellular uptake mechanisms and drug release kinetics, as well as developing functional food additives to improve the bioavailability of nutritional components.

MCE contains 192 liposome compounds, which is a good tool for lipidomic-related studies.

Cat. No.	Product Name	Target	Research Area

HY-P1449

Boc-Gly-Gly-Phe-Gly-OH	ADC Linker	Cancer
Boc-Gly-Gly-Phe-Gly-OH, a self-assembly of N- and C-protected tetrapeptide, is a protease cleavable linker used for the antibody-drug conjugate (ADC).

HY-P4808

PHF6	Amyloid-β Autophagy	Neurological Disease
PHF6 (VQIVYK) is a self-assembly sequence capable of initiating the full-length tau protein aggregation and is mapped to the third microtubule-binding repeat region of the tau protein .

HY-P4637

Ile-Phe H-Ile-Phe-OH	Amyloid-β	Others
Ile-Phe is a dipeptide that self-associates in aqueous solution to form a transparent thermoreversible gel formed by a network of fibrillar nanostructures. It may be involved in triggering self-assembly processes such as amyloid formation.

HY-P4808A

PHF6 TFA	Amyloid-β Autophagy	Neurological Disease
PHF6 (VQIVYK) TFA is a self-assembly sequence capable of initiating the full-length tau protein aggregation. PHF6 TFA is mapped to the third microtubule-binding repeat region of the tau protein .

HY-P5681

Human α-Defensin 6	Bacterial	Infection Inflammation/Immunology
Human α-Defensin 6, a 32-residue cysteine-rich peptide, can inhibit bacterial invasion and contribute to the mucosal immunity. Human α-Defensin 6 forms ordered self-assembly fibrils and nanonets that surround and entangle bacteria after stochastic binding to bacterial surface proteins. Human α-Defensin 6 also inhibits C. albicans biofilm formation .

HY-P1449A

Boc-Gly-Gly-Phe-Gly-OH TFA	ADC Linker	Cancer
Boc-Gly-Gly-Phe-Gly-OH TFA, a self-assembly of N- and C-protected tetrapeptide, is a protease cleavable linker used for the antibody-drug conjugate (ADC).

HY-P10701

Q11 peptide	Biochemical Assay Reagents	Inflammation/Immunology Cancer
Q11 peptide is a β-sheet-forming peptide that plays an important role in self-assembly and targeted applications. As a scaffold peptide, Q11 peptide can display immunogenic epitopes and is widely used in peptide-based immune vaccine research. Additionally, Q11 peptide can be conjugated with MUC1 glycopeptides for the study of self-assembling, adjuvant-free MUC1 glycopeptide vaccines. Q11 peptide holds great potential for research in the field of cancer immunology .

HY-P10494

FEFEFKFK	Amyloid-β	Neurological Disease
FEFEFKFK is an octapeptide that self-assembles into fibrillar structures. FEFEFKFK is able to form gels at concentrations greater than about 7 mg/mL. The self-assembly and gelation properties of FEFEFKFK help to understand the mechanism of amyloid fibril formation in protein misfolding diseases such as Alzheimer's disease and Parkinson's disease .

HY-P4147

Ac-IHIHIQI-NH2	Peptides	Others
Ac-IHIHIQI-NH2 is a fibril-forming heptapeptide with high catalytic activity to laccase mimics. Ac-IHIHIQI-NH2 exhibits selectivity for hydrophobic p-nitrophenyl (ONp) ester substrates in the process of self-assembly .

HY-P10669

NDI-Lyso	Caspase Apoptosis	Cancer
NDI-Lyso is a lysosome-targeted anticancer agent that induces the formation of rigid long fibers in cancer cell lysosomes through an *enzyme-instructed self-assembly* (EISA) mechanism catalyzed by cathepsin B. This process triggers lysosomal swelling, membrane permeabilization (LMP), and membrane disruption, ultimately leading to cancer cell apoptosis via a non-classical caspase-independent pathway. NDI-Lyso exhibits significant selective anticancer activity in various cancer cell lines and drug-resistant cancer cells (IC₅₀ ~10 μM) while showing low toxicity to normal cells (IC₅₀** > 60 μM) .

HY-P10453

Myr5A peptide	Peptides	Others
Myr5A peptide is an acylated peptide composed of apolipoprotein A1 (ApoA1) analog peptide 5A peptide coupled to the saturated fatty acid myristate. Myr5A peptide self-assembled into lipid nanostructures can be used to encapsulate anthracycline Doxorubicin (HY-15142A) and Valrubicin (HY-13772) for compound release studies in vitro .

HY-P11231

β4-TAT FUS(364-369)-TAT	Peptides	Cancer
β₄-TAT is a kind of β-sheet peptide foldamer. β₄-TAT is composed of two parts: the β4 sequence (derived from the β-sheet fragment of the RRM domain of fused in sarcoma (FUS)) and the TAT sequence (a nuclear localization signal peptide that helps the entire peptide penetrate the nuclear membrane). β₄-TAT influences FUS aggregation by targeting its RNA recognition motifs (RRM). β4-TAT effectively induces FUS aggregation within cells, leading to the death of cancer cells. β₄-TAT can be used for the study of FUS .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0687

Vindoline 1 Publications Verification	Apocynaceae Alkaloids Structural Classification Classification of Application Fields Plants Disease Research Fields Indole Alkaloids Catharanthus roseus (L.) G. Don Source Classification Cancer	Microtubule/Tubulin Apoptosis NF-κB PERK
Vindoline is an orally active vinca alkaloid. Vindoline can be extracted from the leaves of Catharanthus roseus. Vindoline has a weak inhibitory effect on the self-assembly of tubulin. Vindoline alleviates Apoptosis, inhibits p-p65 and p-ERK. Vindoline improves diabetes, bone loss, osteoarthritis, and kidney damage .

HY-121447

Heneicosanoic acid	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
Heneicosanoic acid is an odd-chain saturated fatty acid widely present in human milk, fish, seeds, and cerebrosides in the cell membranes of the nervous system. Heneicosanoic acid can form Langmuir monolayers and is often used as a model to study lipid self-assembly and disassembly processes in biological membranes and drug delivery systems. In the low-temperature L'2 and CS crystalline phases, Heneicosanoic acid undergoes local oscillations, which in turn drive the spontaneous formation and expulsion of micelles and vesicles .

HY-N0687R

Vindoline (Standard)	Apocynaceae Alkaloids Structural Classification Plants Indole Alkaloids Catharanthus roseus (L.) G. Don Source Classification	Reference Standards Microtubule/Tubulin Apoptosis NF-κB PERK
Vindoline (Standard) is an analytical standard of Vindoline (HY-N0687). This product is intended for research and analytical applications. Vindoline is an orally active vinca alkaloid. Vindoline can be extracted from the leaves of Catharanthus roseus. Vindoline has a weak inhibitory effect on the self-assembly of tubulin. Vindoline alleviates Apoptosis, inhibits p-p65 and p-ERK. Vindoline improves diabetes, bone loss, osteoarthritis, and kidney damage .

Cat. No.	Product Name	Chemical Structure

HY-B0949AS

Protriptyline-d3
Protriptyline-d₃ is deuterium labeled Protriptyline (HY-B0949). Protriptyline is a potent tricyclic antidepressant (TCA). Protriptyline inhibits AChE activity with an IC₅₀ value of 0.06 mM and inhibits Aβ self-assembly. Protriptyline can be used for the study of depression and Alzheimers disease .

Cat. No.	Product Name		Classification

HY-167071

PLLA-azide (MW 5000)		Azide
PLLA-azide (MW 5000) is a polylactic acid derivative that can self-assemble in water. PLLA-azide (MW 5000) can be used in drug delivery research .

HY-167117

PLLA-azide (MW 10000)		Azide
PLLA-azide (MW 10000) is a polylactic acid derivative that can self-assemble in water. PLLA-azide (MW 10000) can be used in drug delivery research .

HY-167115

PLLA-azide (MW 20000)		Azide
PLLA-azide (MW 20000) is a polylactic acid derivative that can self-assemble in water. PLLA-azide (MW 20000) can be used in drug delivery research .

Cat. No.	Product Name		Classification

HY-154644

Soya Lecithin		Emulsifiers Solubilizing Agents
Soya Lecithin is a phospholipid mixture that can be used as a drug delivery vehicle and is a pharmaceutical excipient. Soya Lecithin can form a lipid bilayer structure through self-assembly, and its binding properties are amphiphilic (hydrophilic head and hydrophobic tail), encapsulating hydrophobic drugs. Soya Lecithin forms stable nanoliposomes or microemulsions, improves the solubility and cellular uptake efficiency of poorly soluble drugs (such as Curcumin (HY-N0005)), and exerts activities such as enhancing drug delivery and regulating cell proliferation .

HY-W440702

Cholesterol-PEG2000-NHS		Pegylated Lipids
Cholesterol-PEG2000-NHS is a cholesterol PEG derivative that can form micelles through molecular self-assembly and has a longer half-life in vivo. Cholesterol-PEG2000-NHS can be used in drug delivery research .

HY-W440697

Cholesterol-PEG1000-NHS		Pegylated Lipids
Cholesterol-PEG1000-NHS is a cholesterol PEG derivative that can form micelles through molecular self-assembly and has a longer half-life in vivo. Cholesterol-PEG1000-NHS can be used in drug delivery research .

HY-W440718

Cholesterol-PEG1000-Mal		Pegylated Lipids
Cholesterol-PEG1000-Mal is a cholesterol PEG derivative that can form micelles through molecular self-assembly and has a longer half-life in vivo. Cholesterol-PEG1000-Mal can be used in drug delivery research .

HY-W440704

Cholesterol-PEG5000-NHS		Pegylated Lipids
Cholesterol-PEG5000-NHS is a cholesterol PEG derivative that can form micelles through molecular self-assembly and has a longer half-life in vivo. Cholesterol-PEG5000-NHS can be used in drug delivery research .

HY-W440695

Cholesterol-PEG3400-azide		Pegylated Lipids
Cholesterol-PEG3400-azide is a cholesterol PEG derivative that can form micelles through molecular self-assembly and has a longer half-life in vivo. Cholesterol-PEG3400-azide can be used in drug delivery research .

HY-W440692

Cholesterol-PEG5000-amine		Pegylated Lipids
Cholesterol-PEG5000-amine is a cholesterol PEG derivative that can form micelles through molecular self-assembly and has a longer half-life in vivo. Cholesterol-PEG5000-amine can be used in drug delivery research .

HY-W440696

Cholesterol-PEG5000-azide		Pegylated Lipids
Cholesterol-PEG5000-azide is a cholesterol PEG derivative that can form micelles through molecular self-assembly and has a longer half-life in vivo. Cholesterol-PEG5000-azide can be used in drug delivery research .

HY-W440723

Cholesterol-PEG2000-Thiol		Pegylated Lipids
Cholesterol-PEG2000-Thiol is a cholesterol PEG derivative that can form micelles through molecular self-assembly and has a longer half-life in vivo. Cholesterol-PEG2000-Thiol can be used in drug delivery research .

HY-W440707

Cholesterol-PEG3400-alcohol		Pegylated Lipids
Cholesterol-PEG3400-alcohol is a cholesterol PEG derivative that can form micelles through molecular self-assembly and has a longer half-life in vivo. Cholesterol-PEG3400-alcohol can be used in drug delivery research .

HY-W440721

Cholesterol-PEG5000-Mal		Pegylated Lipids
Cholesterol-PEG5000-Mal is a cholesterol PEG derivative that can form micelles through molecular self-assembly and has a longer half-life in vivo. Cholesterol-PEG5000-Mal can be used in drug delivery research .

HY-W440693

Cholesterol-PEG1000-azide		Pegylated Lipids
Cholesterol-PEG1000-azide is a cholesterol PEG derivative that can form micelles through molecular self-assembly and has a longer half-life in vivo. Cholesterol-PEG1000-azide can be used in drug delivery research .

HY-W440691

Cholesterol-PEG3400-amine		Pegylated Lipids
Cholesterol-PEG3400-amine is a cholesterol PEG derivative that can form micelles through molecular self-assembly and has a longer half-life in vivo. Cholesterol-PEG3400-amine can be used in drug delivery research .

HY-W440705

Cholesterol-PEG1000-alcohol		Pegylated Lipids
Cholesterol-PEG1000-alcohol is a cholesterol PEG derivative that can form micelles through molecular self-assembly and has a longer half-life in vivo. Cholesterol-PEG1000-alcohol can be used in drug delivery research .

HY-W440720

Cholesterol-PEG3400-Mal		Pegylated Lipids
Cholesterol-PEG3400-Mal is a cholesterol PEG derivative that can form micelles through molecular self-assembly and has a longer half-life in vivo. Cholesterol-PEG3400-Mal can be used in drug delivery research .

HY-W440708

Cholesterol-PEG5000-alcohol		Pegylated Lipids
Cholesterol-PEG5000-alcohol is a cholesterol PEG derivative that can form micelles through molecular self-assembly and has a longer half-life in vivo. Cholesterol-PEG5000-alcohol can be used in drug delivery research .

HY-W440703

Cholesterol-PEG3400-NHS		Pegylated Lipids
Cholesterol-PEG3400-NHS is a cholesterol PEG derivative that can form micelles through molecular self-assembly and has a longer half-life in vivo. Cholesterol-PEG3400-NHS can be used in drug delivery research .

HY-W440712

Cholesterol-PEG3400-Biotin		Pegylated Lipids
Cholesterol-PEG3400-Biotin is a cholesterol PEG derivative that can form micelles through molecular self-assembly and has a longer half-life in vivo. Cholesterol-PEG3400-Biotin can be used in drug delivery research .

HY-W440699

Cholesterol-PEG3400-acid		Pegylated Lipids
Cholesterol-PEG3400-acid is a cholesterol PEG derivative that can form micelles through molecular self-assembly and has a longer half-life in vivo. Cholesterol-PEG3400-acid can be used in drug delivery research .

HY-W440700

Cholesterol-PEG5000-acid		Pegylated Lipids
Cholesterol-PEG5000-acid is a cholesterol PEG derivative that can form micelles through molecular self-assembly and has a longer half-life in vivo. Cholesterol-PEG5000-acid can be used in drug delivery research .

HY-W440726

Cholesterol-PEG1000-Vinylsulfone		Pegylated Lipids
Cholesterol-PEG1000-Vinylsulfone is a cholesterol PEG derivative that can form micelles through molecular self-assembly and has a longer half-life in vivo. Cholesterol-PEG1000-Vinylsulfone can be used in drug delivery research .

HY-W440728

Cholesterol-PEG3400-Vinylsulfone		Pegylated Lipids
Cholesterol-PEG3400-Vinylsulfone is a cholesterol PEG derivative that can form micelles through molecular self-assembly and has a longer half-life in vivo. Cholesterol-PEG3400-Vinylsulfone can be used in drug delivery research .

HY-W440717

Cholesterol-PEG5000-Folate		Pegylated Lipids
Cholesterol-PEG5000-Folate is a cholesterol PEG derivative that can form micelles through molecular self-assembly and has a longer half-life in vivo. Cholesterol-PEG5000-Folate can be used in drug delivery research .

HY-W440716

Cholesterol-PEG3400-Folate		Pegylated Lipids
Cholesterol-PEG3400-Folate is a cholesterol PEG derivative that can form micelles through molecular self-assembly and has a longer half-life in vivo. Cholesterol-PEG3400-Folate can be used in drug delivery research .

HY-W440725

Cholesterol-PEG5000-Thiol		Pegylated Lipids
Cholesterol-PEG5000-Thiol is a cholesterol PEG derivative that can form micelles through molecular self-assembly and has a longer half-life in vivo. Cholesterol-PEG5000-Thiol can be used in drug delivery research .

HY-W440713

Cholesterol-PEG5000-Biotin		Pegylated Lipids
Cholesterol-PEG5000-Biotin is a cholesterol PEG derivative that can form micelles through molecular self-assembly and has a longer half-life in vivo. Cholesterol-PEG5000-Biotin can be used in drug delivery research .

HY-W440709

Cholesterol-PEG10000-alcohol		Pegylated Lipids
Cholesterol-PEG10000-alcohol is a cholesterol PEG derivative that can form micelles through molecular self-assembly and has a longer half-life in vivo. Cholesterol-PEG10000-alcohol can be used in drug delivery research .

HY-W440729

Cholesterol-PEG5000-Vinylsulfone		Pegylated Lipids
Cholesterol-PEG5000-Vinylsulfone is a cholesterol PEG derivative that can form micelles through molecular self-assembly and has a longer half-life in vivo. Cholesterol-PEG5000-Vinylsulfone can be used in drug delivery research .

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