Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
22 Results for "
synaptic binding
" in MedChemExpress (MCE) Product Catalog:
Products (22)
22 Results for "synaptic binding" in MCE Product Catalog:
3
3 Cited Publications
Cat. No.: HY-P2264
CAS No.: 676657-00-4
Target:
Research Areas:
2
2 Cited Publications
Synonyms: S44819; Egis-13529
Target:
Research Areas:
Afizagabar (S44819) is a first-in-class, competitive, and selective antagonist at the GABA-binding site of the α5-GABAAR, with an IC50 of 585 nM for α5β2γ2 and a Ki of 66 nM for α5β3γ2. Afizagabar enhances hippocampal synaptic plasticity and exhibits pro-cognitive efficacy .
1
Category:
Leguminosae/Fabaceae Extract Natural Products Plant Other Diseases Arachis hypogaea L. Extract Disease Research Fields
Target:
1
Category:
Target:
1
1 Cited Publications
Cat. No.: HY-P1297
CAS No.: 120066-38-8
Target:
Research Areas:
Target:
Cat. No.: HY-P10430
Target:
Research Areas:
Cat. No.: HY-167822
CAS No.: 1531600-36-8
Target:
Research Areas:
Caramboxin is a phenylalanine-like α-amino acid neurotoxin found in star fruit (Averrhoa carambola) with glutamatergic ionotropic action. Caramboxin activates NMDA, AMPA, and kainate receptors while inhibiting GABA binding to synaptic membranes, shifting the CNS toward an excitatory state and exerting neurotoxic effects linked to star fruit ingestion. Caramboxin can be used for research on neurotoxicity and as a reference standard for toxicological studies .
Synonyms: CGS 10746
Target:
Research Areas:
Pentiapine (CGS 10746) is a dopamine release inhibitor without binding to synaptic dopamine receptor sites .
Cat. No.: HY-100821
CAS No.: 111872-98-1
Category:
Target:
Cat. No.: HY-106469
CAS No.: 81428-04-8
Synonyms: MY-117
Target:
Research Areas:
Taltrimide (MY-117), a lipophilic derivative of Taurine (HY-B0351), strongly inhibits the sodium-independent binding of Taurine to synaptic membranes of brain, the effects on the binding of GABA being less pronounced. Taltrimide exhibits definitive anticonvulsive effects in experimental epilepsy models .
Cat. No.: HY-P2471
Target:
Research Areas:
Cat. No.: HY-P1297A
Target:
Research Areas:
Cat. No.: HY-115739
CAS No.: 1009376-10-6
Target:
Research Areas:
RTIL 13 is a potent inhibitor of dynamin GTPase, with an IC50 of 2.3 μM for dynamin I GTPase. RTIL 13 also targets pleckstrin homology lipid binding domain. RTIL 13 can inhibit receptor-mediated and synaptic vesicle endocytosis, with IC50s of 9.3 μM and 7.1 μM, respectively .
Cat. No.: HY-B1789
CAS No.: 80880-90-6
Target:
Research Areas:
Telenzepine is an antimuscarinic agent with Kis of 0.94 nM (M1 mAChR) and 17.8 nM (M2 mAChR) binding to muscarinic receptors. Telenzepine effectively blocks synaptic transmission promoted by muscarinic or M1 receptor agonists. Thus, Telenzepine can reduce the amplitude of extracellular slow excitatory postsynaptic potentials (EC50=38 nM) and slow inhibitory postsynaptic potentials (EC50=253 nM) .
Cat. No.: HY-100143R
CAS No.: 81382-51-6
Synonyms: CGS 10746 (Standard)
Target:
Research Areas:
Pentiapine (Standard) is the analytical standard of Pentiapine (HY-100143). This product is intended for research and analytical applications. Pentiapine (CGS 10746) is a dopamine release inhibitor without binding to synaptic dopamine receptor sites .
Cat. No.: HY-165474
CAS No.: 2231103-08-3
Target:
Research Areas:
TDPAM01 is a positive allosteric modulator of AMPA receptor GluA2. TDPAM01 can specifically bind to the ligand-binding domain (LBD) of GluA2 and shows an IC50 of 13.4 nM for the GluA2 flop subtype. TDPAM01 can stabilize the activated conformation of GluA2 receptors, delay the receptor deactivation or desensitization process, maintaining the rapid excitatory synaptic transmission in the central nervous system .
Cat. No.: HY-15129A
CAS No.: 73913-63-0
Synonyms: D-Serine O-phosphate; D-SOP
Target:
Research Areas:
O-Phospho-D-serine (D-SOP) is the D-configurational enantiomer of O-Phospho-L-serine (HY-15129). O-Phospho-D-serine inhibits L-[ 3H]glutamate binding to APB-sensitive sites in rat brain synaptic plasma membranes, with a Ki of 303 μM. Compared with the L-configurational form, D-SOP does not significantly activate the tested mGluR at 1 mM, and it is mainly used in studies related to the stereoselectivity of phosphatidylserine and mGluR ligands .
Cat. No.: HY-D3394
CAS No.: 1331918-67-2
Target:
Research Areas:
SGC5 is a fluorescence enhancer and membrane dissociator with millisecond-scale membrane dissociation kinetics, with an emission spectrum of 500-650 nm. SGC5 produces strong fluorescence upon binding to lipid membranes, exhibits fast partitioning dissociation kinetics at higher temperatures, and is unaffected by pH or cholesterol. SGC5 does not belong to the FM dye family and shows the highest membrane-bound fluorescence intensity among the tested styryl/FM dyes. SGC5 can be used to study synaptic vesicle cycling in neurons .
Cat. No.: HY-165475
CAS No.: 2231101-34-9
Target:
Research Areas:
TDPAM02 is a potent positive allosteric modulator of the AMPA receptor GluA2 subunit, with an EC50 of 1.4 nM for the GluA2 flop (Q) subunit. TDPAM02 binds at the dimer interface of the GluA2 ligand-binding domain and stabilizes the receptor conformation by simultaneously occupying two allosteric sites, thereby significantly slowing the receptor desensitization process and maintaining rapid excitatory synaptic transmission in the central nervous system. TDPAM02 is also a positive allosteric modulator of the GluK1 receptor. TDPAM02 can be used for research on neurological diseases .
- 1
- 2
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
