21 Results for "

tanshinone

" in MedChemExpress (MCE) Product Catalog:
Products (21)

21 Results for "tanshinone" in MCE Product Catalog:

47
47 Publications Verification
Cat. No.: HY-N0174
CAS No.: 35825-57-1
Synonyms: Cryptotanshinon; tanshinone c
Cryptotanshinone is a natural compound extracted from the root of Salvia miltiorrhiza Bunge that shows antitumor activities. Cryptotanshinone inhibits STAT3 with an IC50 of 4.6 μM.
loading...
    loading...
37
37 Cited Publications
Cat. No.: HY-N0135
CAS No.: 568-72-9
Synonyms: Dan Shen ketone
Tanshinone IIA (Tan IIA) is one of the main compositions in the root of Salvia miltiorrhiza Bunge. Tanshinone IIA may suppress angiogenesis by targeting the protein kinase domains of VEGF/VEGFR2.
loading...
    loading...
7
7 Cited Publications
Cat. No.: HY-N1370
CAS No.: 69659-80-9
Synonyms: Sodium tanshinone IIA sulfonate; tanshinone IIA sodium sulfonate
Tanshinone IIA sulfonate (sodium) is a derivative of tanshinone IIA, which acts as an inhibitor of store-operated Ca 2+ entry (SOCE), and is used to treat cardiovascular disorders.
loading...
    loading...
5
5 Cited Publications
Cat. No.: HY-N0134
CAS No.: 568-73-0
Synonyms: tanshinone A
Tanshinone I is an inhibitor of type IIA human recombinant sPLA2 (IC50=11 μM) and rabbit recombinant cPLA2 (IC50=82 μM).
loading...
    loading...
1
1 Cited Publications
Cat. No.: HY-NP001
Synonyms: CBSA
Cationic Bovine Serum Albumin is a bovine serum albumin (BSA) modified with excess ethylenediamine, which has enhanced immunogenicity compared to native BSA. Positively charged primary amines block all negatively charged carboxyl groups, making Cationic Bovine Serum Albumin a cationic protein. Cationic Bovine Serum Albumin has remarkable neuroprotective effects on ischemic stroke when in combination with Tanshinone IIA (HY-N0135) .
loading...
    loading...
Cat. No.: HY-N1179
CAS No.: 17397-93-2
Tanshinone IIB is a major active constituent of the roots of Salvia miltiorrhiza (Danshen) widely used for the research of stroke and coronary heart disease in Asian countries. Tanshinone IIB has a neuroprotective effect via inhibition of apoptosis .
loading...
    loading...
Cat. No.: HY-N10686
CAS No.: 61077-78-9
Tanshinone IIA anhydride, present in root extracts of Salvia miltiorrhiza, acts as an inhibitor of human carboxylesterase (CE). Tanshinone IIA anhydride has a Ki value of 1.9 nM against hCE1 and a Ki value of 1.4 nM against hiCE. Tanshinone IIA anhydride forms a stable covalent complex with serine Ser221 at the active site of hCE1, blocking the catalytic cycle of carboxylesterase, and the activity of the inactivated enzyme cannot recover spontaneously. Tanshinone IIA anhydride is applicable in metabolism-related studies .
loading...
    loading...
Cat. No.: HY-N7761
CAS No.: 126979-84-8
Synonyms: Tetrahydro tanshinone I
Target:  

Bacterial

Research Areas:  

Cancer

Trijuganone B (Tetrahydro tanshinone I) is a naturally occurring covalent pan-inhibitor of gut microbial bile salt hydrolases that can be isolated from Salvia trijuga. Trijuganone B inhibits total gut microbial bile salt hydrolase activity in live microorganisms and murine gut luminal content. Trijuganone B can be used for the research of bile-acid-related metabolic disorders .
loading...
    loading...
Cat. No.: HY-N7177
CAS No.: 18887-18-8
Hydroxytanshinone IIA is a hydroxylated metabolite of Tanshinone IIA. Tanshinone IIA may suppress angiogenesis by targeting the protein kinase domains of VEGF/VEGFR2 .
loading...
    loading...
Cat. No.: HY-168539
Target:  

HuR

Research Areas:  

Inflammation/Immunology

TM11, a Tanshinone mimic, is a potent HuR inhibitor that can inhibit HuR-RNA complex formation. TM11 reduces LPS-induced inflammatory response in murine macrophages .
loading...
    loading...
Cat. No.: HY-N3734
CAS No.: 27468-20-8
Deoxyneocryptotanshinone, a natural tanshinone, is a high affinity BACE1 (Beta-secretase) inhibitor with an IC50 value of 11.53 μM. Deoxyneocryptotanshinone shows a promising dose-dependent inhibition of protein tyrosine phosphatase 1B (PTP1B) with an IC50 value of 133.5 μM. Deoxyneocryptotanshinone can be used for Alzheimer's disease research .
loading...
    loading...
Cat. No.: HY-N0135R
CAS No.: 568-72-9
Synonyms: Dan Shen ketone (Standard)
Tanshinone IIA (Standard) is the analytical standard of Tanshinone IIA. This product is intended for research and analytical applications. Tanshinone IIA (Tan IIA) is one of the main compositions in the root of Salvia miltiorrhiza Bunge. Tanshinone IIA may suppress angiogenesis by targeting the protein kinase domains of VEGF/VEGFR2.
loading...
    loading...
Cat. No.: HY-N1370R
CAS No.: 69659-80-9
Synonyms: Sodium tanshinone IIA sulfonate (Standard); tanshinone IIA sodium sulfonate (Standard)
Tanshinone IIA sulfonate (sodium) (Standard) is the analytical standard of Tanshinone IIA sulfonate (sodium). This product is intended for research and analytical applications. Tanshinone IIA sulfonate (sodium) is a derivative of tanshinone IIA, which acts as an inhibitor of store-operated Ca2+ entry (SOCE), and is used to treat cardiovascular disorders.
loading...
    loading...
Cat. No.: HY-N0134R
CAS No.: 568-73-0
Synonyms: tanshinone A (Standard)
Tanshinone I (Standard) is the analytical standard of Tanshinone I. This product is intended for research and analytical applications. Tanshinone I is an inhibitor of type IIA human recombinant sPLA2 (IC50=11 μM) and rabbit recombinant cPLA2 (IC50=82 μM).
loading...
    loading...
Cat. No.: HY-N10908
CAS No.: 2569515-88-2
Tanshinoic acid A, a oxidic tanshinone diterpenoid, is a 11,12-seco-tanshinone derivative .
loading...
    loading...
Cat. No.: HY-N12736
CAS No.: 1444618-61-4
Dehydrodanshenol A is a non-competitive inhibitor of Protein tyrosine phosphatase 1B (PTP1B), with an IC50 value of 8.5 μM. Dehydrodanshenol A can be used in diabetes-related research .
loading...
    loading...
Cat. No.: HY-N0174R
CAS No.: 35825-57-1
Synonyms: Cryptotanshinon (Standard); tanshinone c (Standard)
Cryptotanshinone (Standard) is the analytical standard of Cryptotanshinone. This product is intended for research and analytical applications. Cryptotanshinone is a natural compound extracted from the root of Salvia miltiorrhiza Bunge that shows antitumor activities. Cryptotanshinone inhibits STAT3 with an IC50 of 4.6 μM.
loading...
    loading...
Cat. No.: HY-126416
CAS No.: 18887-19-9
Methyl tanshinonate is a tanshinone, that can be isolated from Salvia miltiorrhiza (S. miltiorrhiza) Bunge (Lamiaceae). Methyl tanshinonate is a potent inhibitor of M pro enzyme in SARS-CoV (IC50 = 21.1 µM). Methyl tanshinonate can be used for diabetes and SARS-CoV research .
loading...
    loading...
Cat. No.: HY-186160
CAS No.: 937261-96-6
Target:  

Drug Intermediate

Research Areas:  

Others

Tanshinone IIA acid is a starting material for synthesizing tanshinone IIA piperazine compounds that act as calcium channel antagonists with vascular endothelial cell protective activity .
loading...
    loading...
Cat. No.: HY-N8617
CAS No.: 135247-94-8
Trijuganone C is a tanshinone-type diterpenoid compound. Trijuganone C can be isolated from the roots of Salvia miltiorrhiza Bunge. Trijuganone C induces chromatin condensation, DNA fragmentation, activation of Caspase-3, -8 and -9, as well as cleavage of PARP. Trijuganone C activates Bid and Bax, leading to loss of mitochondrial membrane potential and inducing the release of cytochrome c from mitochondria into the cytosol. Trijuganone C exerts antiproliferative effects through Apoptosis induction mediated by Mitochondrial dysfunction and Caspase activation. Trijuganone C exhibits significant antiproliferative activity against leukemia cells and colon cancer cells .
loading...
    loading...