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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
105 Results for "
thermal stability
" in MedChemExpress (MCE) Product Catalog:
Products (105)
105 Results for "thermal stability" in MCE Product Catalog:
1
Target:
Research Areas:
MOPS is a buffering agent used in biology. MOPS buffer maintains the pH of mammalian cell culture media. MOPS significantly improves the thermal stability of BSA (HY-D0842) .
1
1 Cited Publications
Cat. No.: HY-D0859A
CAS No.: 71119-22-7
1
1 Cited Publications
Cat. No.: HY-15929
CAS No.: 14348-40-4
Synonyms: 2,4,6-Tribromo-3-hydroxybenzoic acid
1
1 Cited Publications
Cat. No.: HY-163987
CAS No.: 3061491-60-6
Target:
Research Areas:
SIRT3 activator 2 (compound 2a) is a SIRT3 activator. SIRT3 activator 2 improved the thermal stability of SIRT3 in SH-SY5Y cells, indicating that it can directly bind to SIRT3, has SIRT3 dependency in SH-SY5Y to clear α-Syn. SIRT3 activator 2 improves motor function in Parkinson mice, preventing Parkinson (DA) neuron loss in the substantia nigra in a dose-dependent manner .
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1 Cited Publications
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MN551 is a covalent modulator of SOCS2 and CISH, with selectivity for SOCS2 and CISH over SOCS4. MN551 covalently modifies Cys111 in the SH2 domain of SOCS2 and Cys144 in the EF loop of the CISH SH2 domain, while only minimally modifying Cys471 in the BG loop of the SOCS6 SH2 domain. MN551 increases the thermal stability of the recombinant SOCS2-ElonginB-ElonginC complex and competitively blocks the binding of SOCS2 to its substrate; when delivered via the prodrug MN714, it blocks the intracellular recruitment of substrates by SOCS2. MN551 can serve as a chemical probe for investigating the biological functions of SOCS2 and its CRL5 complex, and also act as an E3 ligase-binding module in proteolysis-targeting chimeras (PROTACs) .
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1 Cited Publications
Cat. No.: HY-W036410
CAS No.: 13822-56-5
Synonyms: 3-Aminopropyltrimethoxysilane
Cat. No.: HY-W250308
CAS No.: 28211-04-3
Synonyms: Epsilon-polylysine (MW 3800-4200); ε-Polylysine (MW 3800-4200); ε-PL (MW 3800-4200)
Cat. No.: HY-D2001
CAS No.: 863772-22-9
Cat. No.: HY-W250721A
CAS No.: 9007-20-9
Synonyms: CBM 940
Cat. No.: HY-W127717
CAS No.: 51142-49-5
Synonyms: Perfluoro-compound FC-40
Cat. No.: HY-W007596
CAS No.: 94928-86-6
Synonyms: Ir(ppy)3; Tris[2-(pyridin-2-yl)phenyl]iridium
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Tris(2-phenylpyridinato-C2,N)iridium(III) (Ir(ppy)3) is an iridium(III) containing organometallic complex, which is used as a phosphorescent light-emitting material. Tris(2-phenylpyridinato-C2,N)iridium(III) exhibits high luminous efficiency and good thermal stability, that can be used in organic optoelectronics, especially in improving the luminescence efficiency and stability of organic light-emitting diodes (OLEDs) .
Cat. No.: HY-168534
CAS No.: 2929223-35-6
WX-02-23 is a small-molecule probe that stereoselectively and site-specifically binds to C258 of FOXA1 and C1111 of SF3B1. WX-02-23 remodels FOXA1's chromatin binding and pioneer activity in a DNA-dependent manner, disrupts spliceosome assembly, and enhances the thermal stability of SF3B1. WX-02-23 inhibits tumor cell proliferation and induces apoptosis. WX-02-23 can be used for research on cancers such as prostate cancer .
Cat. No.: HY-W094846
CAS No.: 629-59-4
Synonyms: n-Tetradecane
Research Areas:
Tetradecane (n-Tetradecane) is a low-temperature phase change material with a phase change temperature of 5°C and a latent heat of phase change of 220 J/g. Tetradecane undergoes solid-liquid phase transition around 5°C, and achieves temperature regulation by absorbing or releasing latent heat .
Cat. No.: HY-104035H
CAS No.: 63148-62-9
Synonyms: Poly(dimethylsiloxane) (PDMS), viscosity 10 cSt (25 °C); Dimethylsilcone fluid, viscosity 10 cSt (25 °C)
Synonyms: (R)-VX-445
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Research Areas:
(R)-Elexacaftor ((R)-VX-445) is the enantiomer of Elexacaftor (HY-111772). Elexacaftor is an orally active CFTR modulator that targets nucleotide-binding domain 1. Elexacaftor stabilizes misfolded F508del-CFTR protein, enhances its trafficking to the plasma membrane, and significantly improves metabolic stability, thermal stability and ion conductivity. Elexacaftor not only restores chloride transport function in nasal epithelial cells and rescues multiple CFTR mutation subtypes, but also exerts multiplicative synergistic effects with Ivacaftor (HY-13017), and is often used in a triple combination therapy with Tezacaftor (HY-15448). Elexacaftor is widely used in basic and clinical translational research on cystic fibrosis .
Cat. No.: HY-W250308A
Synonyms: Epsilon-polylysine hydrochloride (MV 2000-5000); ε-Polylysine hydrochloride (MV 2000-5000); ε-PL hydrochloride (MV 2000-5000)
Cat. No.: HY-W250309
CAS No.: 7575-23-7
Cat. No.: HY-176862
CAS No.: 352513-86-1
Research Areas:
TCB-32 (Compound I-1) is a FGFR1 agonist with an EC50 of 0.88 μM. TCB-32 significantly increases cell proliferation through activating FGFR1 signaling pathway as bFGF and its downstream ERK1/2 with excellent thermal stability. TCB-32 can replace bFGF in serum-free cell culture media. TCB-32 can be used for tissue repair and wound healing related diseases like psoriasis and eczema research .
Cat. No.: HY-D2001A
Target:
Research Areas:
SphK1&2-IN-1 is a SphK inhibitor targeting to SphK1 and SphK2. SphK1&2-IN-1 has thermal stability .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
