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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
36 Results for "
thickness
" in MedChemExpress (MCE) Product Catalog:
Products (36)
36 Results for "thickness" in MCE Product Catalog:
757
757 Cited Publications
Synonyms: N-Acetylcysteine; N-Acetyl-L-cysteine; NAC
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1 Cited Publications
LP-922056 is an orally active, highly potent Notum Pectinacetylesterase inhibitor with EC50s of 21 nM, 55 nM in human and mouse cellular assay, respectively. LP-922056 significantly increases midshaft femur cortical bone thickness in mice and rats .
Cat. No.: HY-144007
CAS No.: 27321-96-6
Chol-PEG is an amphiphilic cholesterol-polyethylene glycol conjugate and also a liposomelike surface modifier. After Chol-PEG is incorporated into liposomelike vesicles, it forms a hydrophilic barrier on their surface, increases the thickness of the bound water layer around the liposomelike vesicles, and enhances the release rate of encapsulated compounds. Chol-PEG can be used as a modifier to prepare nonionic surfactant vesicles (liposomelike vesicles) for drug delivery applications .
Synonyms: tetra-isopalmitoyl Ascorbic acid; IPAA; Tetrahexyldecyl Ascorbate
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Ascorbyl tetra-2-hexyldecanoate (tetra-isopalmitoyl Ascorbic acid; IPAA) is a lipophilic derivative of vitamin C (L-ascorbic acid). Ascorbyl tetra-2-hexyldecanoate (100 μM ) can prevent the decrease in viability of HaCaT keratinocytes induced by UVB, hydrogen peroxide, or tert-butyl hydroperoxide, and reduce the production of IL-1α and prostaglandin E2 (PGE2). Topical application of ascorbyl tetra-2-hexyldecanoate (1%) increases epidermal viability thickness, stratum corneum water content, and skin smoothness, and reduces skin roughness in hairless mice. Ascorbyl tetra-2-hexyldecanoate can be used to develop skin whitening agents in the beauty industry.
Cat. No.: HY-W089800
CAS No.: 18829-56-6
Synonyms: trans-2-Nonen-1-al
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trans-2-Nonenal (trans-2-Nonen-1-al) is an endogenous peroxidation product of polyunsaturated fatty acids, acting as an inhibitor of COX and 12-LOX, as well as an inducer of apoptosis. trans-2-Nonenal is also a malodorous compound secreted by the human body, and its content gradually increases with aging. trans-2-Nonenal inhibits the activities of multiple enzymes such as platelet membrane-bound PTPase, preferentially covalently modifies proteins at lysine residues to form immunogenic adducts, and regulates platelet Arachidonic acid (HY-109590) metabolism. trans-2-Nonenal also exhibits significant cytotoxicity, reduces the viability of keratinocytes, promotes their apoptosis, and effectively decreases the thickness of epidermal models and the number of proliferating cells. trans-2-Nonenal is commonly used in studies of thrombotic, atherosclerotic diseases, renal adenocarcinoma, etc. .
Cat. No.: HY-W143531
CAS No.: 133331-77-8
Synonyms: NOV03; SHR8058
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Perfluorohexyloctane (NOV03), a semifluorinated alkane, reduces tear film instability in Meibomian gland dysfunction and evaporative dry eye disease. Perfluorohexyloctane is a long-term tamponade agent. Perfluorohexyloctane increases tear film breakup time and lipid layer thickness .
Cat. No.: HY-P990012
CAS No.: 2744320-12-3
Synonyms: EBI-031
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Cat. No.: HY-B0215S
CAS No.: 131685-11-5
Synonyms: N-Acetylcysteine-d3; N-Acetyl-L-cysteine-d3; NAC-d3
Cat. No.: HY-P2263
CAS No.: 800379-47-9
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Cat. No.: HY-176886
CAS No.: 2248728-49-4
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LATS-IN-2 is an efficiently acting LATS (large tumor suppressor kinase) inhibitor. LATS-IN-2 shows potent inhibitory activity against LATS1 with an IC50 value of 1.3 nM. LATS-IN-2 suppresses the phosphorylation of YAP by inhibiting LATS kinase activity. LATS-IN-2 increases the thickness of the epidermis in mice. LATS-IN-2 can be used for the study of ocular diseases such as limbal stem cell deficiency and corneal endothelial dysfunction .
Synonyms: RXP-470
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RXP470.1 (RXP-470) is a potent, selective MMP-12 inhibitor with a Ki of 0.2 nM against human MMP-12. RXP470.1 is 2 to 4 orders of magnitude less potent against other MMPs. RXP470.1 significantly reduces atherosclerotic plaque cross-sectional area in mouse. RXP470.1 results in less complex plaques with increased smooth muscle cell:macrophage ratio, less macrophage apoptosis, increased cap thickness, smaller necrotic cores, and decreased incidence of calcification .
Cat. No.: HY-P2612
CAS No.: 199999-60-5
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Synonyms: N-Acetylcysteine (Standard); N-Acetyl-L-cysteine (Standard); NAC (Standard)
Cat. No.: HY-W996116
CAS No.: 1933460-23-1
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Cardiovascular Disease Neurological Disease Inflammation/Immunology
AZM198 is an orally active myeloperoxidase (MPO) inhibitor. AZM198 irreversibly inactivates MPO (IC50=0.015 μM) via covalent binding to the heme prosthetic group, preferentially targets extracellular MPO activity, and reduces neutrophil extracellular trap formation, reactive oxygen species production and degranulation. AZM198 increases the fibrous cap thickness of atherosclerotic plaques, reduces lesion area, ameliorates hepatic steatosis and fibrosis in non-alcoholic steatohepatitis, and alleviates proteinuria and inflammatory infiltration associated with glomerulonephritis. AZM198 also decreases circulating levels of high-sensitivity Cardiac Troponin I and IL-1β, and mitigates endothelial cell injury. Therefore, AZM198 is suitable for research on various MPO-related diseases, including atherosclerotic cardiovascular disease, myocardial infarction, ischemic stroke, non-alcoholic steatohepatitis and crescentic glomerulonephritis .
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TR-100 is a Tpm3.1 inhibitor that binds to and disrupts Tpm3.1-containing Actin filaments, enhancing the depolymerizing effect of Tpm3.1 on actin without altering actin-tropomyosin binding. TR-100 induces actin cytoskeleton rearrangement. TR-100 shortens membrane nanotubes and alters tube thickness in a concentration-dependent manner. TR-100 increases basal insulin secretion and inhibits glucose-stimulated insulin secretion. TR-100 inhibits insulin-stimulated glucose uptake. TR-100 can be used for research on B lymphoma .
Cat. No.: HY-178302
CAS No.: 2882900-86-7
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TNF-α agonistic 2 (Compound 009) is a toxic molecule. TNF-α agonistic 2 reduces the thickness of the right ear in mice. TNF-α agonistic 2 can be used as an ADC toxic molecule .
Cat. No.: HY-N11080
CAS No.: 55903-92-9
Cat. No.: HY-P3164
CAS No.: 928006-50-2
Synonyms: AcTP1
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Acetyl tetrapeptide-9 (AcTP1) is a signal peptide. Acetyl tetrapeptide-9 stimulates the synthesis of Lumican and Collagen, thereby improving skin thickness and firmness .
Cat. No.: HY-B0215S1
Synonyms: N-Acetylcysteine-15N; N-Acetyl-L-cysteine-15N; NAC-15N
Cat. No.: HY-175664
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EYE-003 is an orally active RPE65 inhibitor with an IC50 of 102 nM. EYE-003 regulates the visual cycle in mice by reducing 11-cis-retinal (11cRAL) (HY-116711) synthesis and increasing all-trans-retinyl esters (atREs). EYE-003 suppresses scotopic ERG b-wave amplitude and exerts protective effects against retinal degeneration in Abca4 ⁻/⁻ Rdh8 ⁻/⁻ mice (a STGD1 model) by reducing retinal autofluorescent puncta and preserving outer nuclear layer (ONL) thickness in a dose-dependent manner. EYE-003 can be used for the study of visual cycle-associated retinopathies, such as Stargardt disease type 1 (STGD1) .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
