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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
13 Results for "
thiol substrate
" in MedChemExpress (MCE) Product Catalog:
Products (13)
13 Results for "thiol substrate" in MCE Product Catalog:
Synonyms: 4-Nitrobenzyl mesylate; para-Nitrobenzyl mesylate; PNBM
Target:
Áreas de investigación:
Cardiovascular Disease Neurological Disease Inflammation/Immunology
p-Nitrobenzyl mesylate (4-Nitrobenzyl mesylate) is an alkylating reagent. p-Nitrobenzyl mesylate alkylates thiophosphorylated serine, threonine, tyrosine residues and cysteine thiols, without modifying hydroxyl, amino or carboxylic acid functional groups. p-Nitrobenzyl mesylate generates thiophosphate epitopes on thiophosphorylated substrate proteins for recognition by thiophosphate-specific antibodies. p-Nitrobenzyl mesylate facilitates the identification and purification of kinase substrates. p-Nitrobenzyl mesylate is applicable to studies related to cerebral ischemia-reperfusion injury .
Target:
Áreas de investigación:
Clostripain (Clostridiopeptidase B) is a thiol protease isolated from Clostridium histolyticum. Clostripain exhibits proteolytic activity as well as amidase-esterase activity. The specificity of Clostripain is primarily restricted to arginine residues, but it also shows minor hydrolytic activity toward most lysine-containing substrates. Clostripain catalyzes the ammonolysis of Carbobenzoxyarginyl methyl ester to generate various dipeptides .
Referencia número: HY-W002465
No. CAS: 5570-19-4
Áreas de investigación:
2-Nitrophenylboronic acid is a small-molecule arylboronic acid reagent selective for cysteine residues that mediates nickel (II)-promoted arylation of cysteine thiols. 2-Nitrophenylboronic acid is used in research related to peptide modification and also serves as a substrate for Suzuki-Miyaura coupling reactions in research related to organic synthesis .
Referencia número: HY-P10143
No. CAS: 99828-55-4
Synonyms: Ac-Pro-Leu-Gly-[(S)-2-mercapto-4-methyl-pentanoyl]-Leu-Gly-OEt
Referencia número: HY-131030
No. CAS: 2127150-20-1
Synonyms: JF669, SE; JF669, NHS
Referencia número: HY-W127380
No. CAS: 146797-82-2
Referencia número: HY-E70264
No. CAS: 799812-86-5
Target:
Áreas de investigación:
16:0 Coenzyme A triammonium is palmitoyl-CoA, which can serve as a reaction substrate to transfer the palmitoyl group to the free thiol group of the target protein through palmitoylation catalyzed by protein acyl transferases (PATs) .
Referencia número: HY-W713925
No. CAS: 89019-63-6
Target:
Áreas de investigación:
Diheptanoyl Thio-PC is a substrate for all phospholipase A2s (PLA2s) with the exception of cPLA2 and PAF-acetyl hydrolase (PAF-AH).1 Interaction of this compound with a PLA2 results in cleavage of the sn-2 fatty acid generating a free thiol on the lysophospholipid. This free thiol can be detected using chromogenic substrates such as DTNB (Ellman’s reagent) and DTP.
Referencia número: HY-176085
Target:
Áreas de investigación:
Heptanoyl thio-PC is a sn-2 thiol-labeled Phospholipase A2 (HY-P3029) (PLA2) substrate that can be used to detect the activity of Phospholipase A2 .
Referencia número: HY-D2047
No. CAS: 1632109-97-7
Target:
Áreas de investigación:
ATTO 532 maleimide is a thiol-reactive Fluorescent dye. ATTO 532 maleimide enables site-specific labeling of proteins via maleimide-cysteine chemistry and can be used for single-molecule detection of GroEL EL315C binding/complex formation and single-molecule FRET, and can label surface cysteine substrates, Prothymosin α, Frataxin, and GB1. ATTO 532 maleimide covalently labels Tau, serves as a fluorescence lifetime sensor of amyloid aggregate structural density, and exhibits self-quenching .
Referencia número: HY-123189
No. CAS: 89139-28-6
Target:
Áreas de investigación:
LY 171859 is a D2 receptor agonist with significant reductase activity. LY 171859 exhibits enzymatic activity in the cytoplasm of liver, lung, and kidney, and also contains significant reductase activity in rat and human blood. LY 171859 has higher hepatic reductase activity in guinea pigs, followed by hamsters, rabbits, rats, and mice. The substrate of LY 171859 shows an apparent Km of 5.6 μM. The reduction reaction of LY 171859 is NADPH-dependent with an apparent Km of 14.8 μM. Only the A-side hydrogen of NADPH is incorporated in the reduction product of LY 171859. The reaction of LY 171859 is inhibited by cyanide and thiol reagents, and phenobarbital does not induce its activity in rats .
Referencia número: HY-184840
No. CAS: 43064-23-9
Target:
Áreas de investigación:
(2-Sulfanylethyl)phosphonic acid (compound 2) is a thiol-containing alkylphosphonic acid inhibitor of purple acid phosphatase (PAP), which inhibits PAP derived from red kidney beans with an IC50 of 3000 μM. The phosphonic acid group of (2-Sulfanylethyl)phosphonic acid acts as a non-hydrolyzable phosphate substrate mimic, and the terminal thiol is designed to enhance interactions with the dinuclear metal active center of PAP. (2-Sulfanylethyl)phosphonic acid can be used in studies related to PAP inhibitors and the structure-activity relationships of dinuclear metal phosphatase inhibition .
Referencia número: HY-D2763
No. CAS: 890928-51-5
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
