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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
26 Results for "
turn-on fluorescent probe
" in MedChemExpress (MCE) Product Catalog:
Products (26)
26 Results for "turn-on fluorescent probe" in MCE Product Catalog:
4
4 Cited Publications
Cat. No.: HY-D0155
CAS No.: 288574-78-7
Cat. No.: HY-D2264
CAS No.: 1632296-13-9
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Caffeine Orange (Compound 1) is a fluorescent probe for caffeine detection. Caffeine Orange is a BODIPY backbone-based probe that exhibits a turn-on fluorescence response upon binding to caffeine. The detection mechanism of Caffeine Orange relies on its binding with caffeine in aqueous media, which triggers an increase in fluorescence intensity; under irradiation with a 532 nm light source, the presence of caffeine produces orange fluorescence, with an excitation wavelength of 530 nm and an emission wavelength centered at approximately 620 nm .
Cat. No.: HY-D1256
CAS No.: 2966537-39-1
Synonyms: SSP4
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Sulfane sulfur probe 4 (SSP4) is a fluorescent indicator with high selectivity and sensitivity toward sulfane sulfur (including small-molecule sulfane sulfur and protein-bound sulfane sulfur), and its fluorescence is inhibited by Cu 2+. Sulfane sulfur probe 4 produces a fluorescence turn-on response upon reaction with sulfane sulfur. Sulfane sulfur probe 4 can detect persulfidated proteins including papain, BSA, GAPDH, and human protein disulfide isomerase. Sulfane sulfur probe 4 enables bioimaging of exogenous and endogenous sulfane sulfur in cells .
Cat. No.: HY-176513
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Cy-OH-LP is a turn-on fluorescent and photoacoustic probe that can detect lipid-associated hydroxyl radicals. Cy-OH-LP can be oxidized to Cy7 in the presence of hydroxyl radicals, which displays weak fluorescent and photoacoustic signals in water-soluble environments and strong fluorescent and photoacoustic signals in lipid-rich environments due to its lipid solubility. Cy-OH-LP can be used for in vivo photoacoustic imaging of hydroxyl radicals .
Cat. No.: HY-150175
CAS No.: 1786411-17-3
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HKSOX-1 is a fluorescent probe for the detection and imaging of superoxide anion radicals (O2 •−) with selectivity. HKSOX-1 reacts with superoxide anion radicals, cleaving the aryl triflate group to generate a free phenol and produce turn-on fluorescence. Derivative variants of HKSOX-1 include HKSOX-1r and HKSOX-1m. HKSOX-1 is applicable to studies related to endogenous superoxide detection .
Cat. No.: HY-D1395
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RH-EDA is a rhodamine-based turn-on fluorescent probe for detecting hydroxyl radicals in living systems.
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LysoFP-NO2 is a turn-on fluorescent probe for carbon monoxide (CO) that localizes to the lysosome. In the presence of lysosomal CO, lysoFP-NO2 is transformed into lysoFP-NH2, which is highly fluorescent. LysoFP-NO2 is selective for CO over various reactive nitrogen, oxygen, and sulfur species. It displays excitation/emission maxima of 440/528 nm, respectively, and is not cytotoxic to HepG2 cells for up to five hours when used at a concentration of 30 μM.
Cat. No.: HY-112526
CAS No.: 1004324-99-5
Cat. No.: HY-172333
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HCy-Lyso is a lysosome-targeting turn-on fluorescent probe based on hydrocyanine. HCy-Lyso integrates a hydrocyanine moiety for selective recognition of hydroxyl radicals (•OH) and a morpholine group for lysosome targeting. Upon reacting with •OH, HCy-Lyso undergoes an extension of its π-conjugation system, producing a strong fluorescence signal at 598 nm when excited at 510 nm .
Cat. No.: HY-D1259
CAS No.: 2414276-32-5
Synonyms: VDP-green (NEP)
Cat. No.: HY-149203
Cat. No.: HY-D3442
CAS No.: 3121565-89-4
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ALDH2 probe 5 is a ALDH2 isoform-selective fluorescent probe with an emission wavelength centered at 494 nm. ALDH2 probe 5 is a turn-on fluorescent substrate for ALDH2; in its unreacted aldehyde form, twisted intramolecular charge transfer (TICT) occurs, resulting in fluorescence quenching. After ALDH2 probe 5 is catalytically oxidized to carboxylate by ALDH2, TICT is inhibited and fluorescence is significantly enhanced. ALDH2 probe 5 enables highly sensitive quantitative imaging of ALDH2 activity in recombinant enzymes, live cells, blood, tissue homogenates, and the brains of living mice. ALDH2 probe 5 can be used for studies related to neuroinflammation .
Cat. No.: HY-D3141
Cat. No.: HY-D3180
CAS No.: 1201643-01-7
Cat. No.: HY-D3152
CAS No.: 2361979-91-9
Cat. No.: HY-D3230
Cat. No.: HY-D3200
CAS No.: 3112200-59-3
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Dns-LLC is a cell-permeable Cu +-selective fluorescent probe that forms a 1:1 complex with Cu +. The thiol group of Dns-LLC plays a key binding role, while the sulfonamide and amide groups jointly contribute to the stabilization of the complex. Upon binding to Cu + in aqueous buffer solutions, Dns-LLC generates a turn-on fluorescence response, which can be used for the detection of Cu + in the Golgi apparatus .
Cat. No.: HY-D3602
CAS No.: 2558211-88-2
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Mito-CS1 is a fluorescent probe for imaging and reversible detection of the exchangeable mitochondrial Cu + pool in living cells. Mito-CS1 combines a Cu +-responsive fluorescent platform with a mitochondria-targeted triphenylphosphonium group, which localizes the probe to mitochondria via a proton gradient. Mito-CS1 contains a thioether-rich receptor for the selective recognition and binding of Cu +, triggering a fluorescence turn-on response by inhibiting photoinduced electron transfer. The apo-form of Mito-CS1 has excitation/emission wavelengths of 555/569 nm, while those of Mito-CS1 after binding to Cu + are 550/558 nm .
Cat. No.: HY-D3128
CAS No.: 2348351-60-8
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Mito-RhFe is a Fluorescent probe for mitochondrial labile Fe³⁺ monitoring via imaging and flow cytometry. This probe is a rhodamine-based construct with a spirolactam fluorescence signaling group and an N2-hydroxyethyldiethylenetriamine chelator; its delocalized positive charge enables mitochondria-targeting ability in live cells, and it exhibits fine cell membrane permeability. In its native state, it exists in the non-fluorescent spirolactam form, but upon binding to Fe³⁺, it undergoes a ring-opening conversion to the fluorescent rhodamine form, triggering a turn-on fluorescent response; this process is reversible, as the addition of the metal chelator TPEN removes Fe³⁺ and converts the probe back to its non-fluorescent spirolactam form, and re-addition of Fe³⁺ restores fluorescence. The probe shows high selectivity for Fe³⁺ over most other metal cations present in living systems, with a ~90-fold fluorescence enhancement upon binding to 20 equiv of Fe³⁺. Mito-RhFe has excitation/emission wavelengths of Ex/Em = 540/578 nm, with an ~8 nm bathochromic shift in emission upon Fe³⁺ binding, and it can also be excited at 543 nm for confocal imaging with emission detected at 570-620 nm[1].
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
