Cilengitide (Standard)
Cilengitide (Standard) (EMD 121974 (Standard)) is the analytical standard of Cilengitide (HY-16141). This product is intended for research and analytical applications. Cilengitide (EMD 121974) is an integrin (integrin) inhibitor with blood-brain barrier permeability, with IC50 values against human targets as follows: 0.61 nM for αvβ3, 8.4 nM for αvβ5, 14.9 nM for α5β1, 5400 nM for αIIbβ3, 2050 nM for αvβ6, 2350 nM for αvβ8. Cilengitide inhibits the binding of integrins to vitronectin, fibronectin, fibrinogen and LAP (TGF-β), and serves as an internal standard for solid-phase integrin binding assays. Cilengitide inhibits tumor cell viability, induces apoptosis, reduces the phosphorylation levels of STAT3, AKT and mTOR, downregulates the expression of PD-L1, inhibits cell viability and angiogenesis, regulates anti-tumor immune responses and slows tumor growth. Cilengitide can be used in research related to glioblastoma, melanoma, advanced solid tumors and refractory brain tumors.
For research use only. We do not sell to patients.
- Purity : 98%
- CAS No.: 188968-51-6
- Formula: C27H40N8O7
- Molecular Weight:588.66
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Product Information
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Chemical Information
- Purity & Documentation
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Help & FAQs
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HY-16141
CilengitideIntegrin Inhibitor -
HY-P0278
RGDTripeptide -
HY-P0023
Cyclo(-RGDfK)αvβ3 Integrin Inhibitor -
HY-14571
E7820Angiogenesis Inhibitor -
HY-15701
Leukadherin-1CD11b/CD18 Agonist -
HY-100226
A-205804E-selectin/ICAM-1 Inhibitor -
HY-18644
CWHM-12αV Integrins Inhibitor -
HY-12290
Arg-Gly-Asp-SerIntegrin Inhibitor -
HY-19307
SB-273005αvβ3/αvβ5 Receptor Antagonist -
HY-14951
FirategrastIntegrin Antagonist -
HY-100506
GLPG0187Integrin Receptor Antagonist -
HY-P1740
RGD peptide (GRGDNP)Integrin-Iigand Interaction Inhibitor
Product Information
Information
Application
The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
Chemical Information
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CAS No. 188968-51-6
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Molecular Weight 588.66
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Formula C27H40N8O7
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SMILES
O=C(NCC(N[C@H](C(N[C@H](CC1=CC=CC=C1)C(N([C@H]2C(C)C)C)=O)=O)CC(O)=O)=O)[C@H](CCCNC(N)=N)NC2=O
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Synonyms
EMD 121974 (Standard)
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Cilengitide (Standard) Related Classifications
HY-16141R Related Classifications
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Keywords
- Cilengitide (Standard)
- 188968-51-6
- EMD 121974 (Standard)
- Reference Standards
- Integrin
- TGF-β Receptor
- Apoptosis
- PD-1/PD-L1
- STAT
- Akt
- mTOR
- Transforming growth factor beta receptors
- PD-1/Programmed death-ligand 1
- PKB
- Protein kinase B
- Mammalian target of Rapamycin
- αvβ3
- fibronectin
- αvβ5
- glioblastoma
- α5β1
- integrin
- melanoma
- fibrinogen
- LAP (TGF-β)
- vitronectin
- Inhibitor
- inhibitor
- inhibit