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Cat. No.: HY-N10103

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Neoschaftoside

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Neoschaftoside is a C-glycosyl flavonoid EGFR modulator, antifungal agent, and piercing-sucking stimulant for planthoppers. Neoschaftoside forms stable EGFR complexes, restricts global protein movement, enhances related dynamic processes, and inhibits tumor progression. Neoschaftoside interacts with EGFR core regulatory genes associated with lung cancer. Neoschaftoside inhibits Botrytis cinerea. Neoschaftoside can be used in research related to lung cancer and Botrytis cinerea infections.

For research use only. We do not sell to patients.

Purity: 98.04%
CAS No.: 61328-41-4
Formula: C₂₆H₂₈O₁₄
Molecular Weight:564.49

Storage:

-20°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Neoschaftoside Chemical Structure

CAS No.: 61328-41-4

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Top Publications Citing

Use of MCE Products

Antibody-Drug Conjugates

One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

Biological Activity
- Description
- In Vitro
Chemical Information
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Bioz

Biological Activity

Description

All EGFR Isoforms :

In Vitro

Neoschaftoside binds with high affinity to the ATP-binding cleft of the purified EGFR tyrosine kinase domain (PDB ID: 4ZAU), as evidenced by a Glide docking score of -10.765 and a Glide energy of -63.293 kcal/mol, forming multiple stabilizing hydrogen bonds and hydrophobic contacts^[1].
Neoschaftoside exists in mixed C-glycosylflavones extracted from elicitor-treated Colobanthus quitensis, and the mixture (75 μg/mL extract concentration) inhibits radial mycelial growth of Botrytis cinerea^[2].
Neoschaftoside induces intense stylet probing behavior of Nilaparvata lugens, Sogatella furcifera and Laodelphax striatellus on artificial sucrose medium^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 61328-41-4
Appearance Solid
Molecular Weight 564.49
Formula C₂₆H₂₈O₁₄
Color White to off-white
SMILES

OC1=C([C@@H]2O[C@@H]([C@H]([C@@H]([C@H]2O)O)O)CO)C(O)=C(C(C=C(C3=CC=C(C=C3)O)O4)=O)C4=C1[C@@H]5[C@@H]([C@H]([C@H](CO5)O)O)O
Structure Classification
- Flavonoids
- Flavones
- Phenols
- Polyphenols
Initial Source
- Plants
- Ranunculaceae
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (284 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Gudasi S, et al. Decoding the molecular mechanism via systems biology-based insights into neoschaftoside from Ailanthus altissima targeting lung cancer. Scientific reports. 2025 Dec 25;16(1):3328. [Content Brief]

[2]. Rubilar L, et al. Priming of C-glycoside flavones in Colobanthus quitensis with salicylic acid, methyl jasmonate, pimelic acid, suberic acid, and azelaic acid elicits antifungal activity against Botrytis cinerea. bioRxiv. 2025 Mar 31.

[3]. Kim M, et al. Isolation of C-glycosylflavones as probing stimulant of planthoppers in rice plant. Journal of Chemical Ecology. 1985;11(4):441-452.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Biological Activity
- Description
- In Vitro
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Neoschaftoside

All EGFR Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Neoschaftoside Related Classifications

HY-N10103 Related Classifications