Sunakiment
Sunakiment (AZD-8630) is a humanized IgG1λ monoclonal antibody inhibitor targeting thymic stromal lymphopoietin (TSLP), which enables direct airway delivery via a dry powder inhaler formulation. Sunakiment binds to TSLP and blocks its pro-inflammatory signal transduction. It is applicable to research on refractory asthma, asthma, and moderate-to-severe asthma.
For research use only. We do not sell to patients.
- CAS No.: 2928519-36-0
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Isotype
immunoglobulin Fab VH-G1(CH1-7h)_L-lambda2
Species Reactivity
Human
In Vitro
Sunakiment (AZD-8630) binds to TSLP and blocks its pro-inflammatory signal transduction[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Gene ID
Accession
Q969D9-1
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
Format
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Fab-G1_lambda
Application
ELISA, FACS, Functional assay
Chemical Information
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CAS No. 2928519-36-0
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SMILES
N/A
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Synonyms
AZD-8630
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Komori HK, et al. Potential of alarmin-targeted bispecific and combination therapies in airway disease. Frontiers in allergy. 2025;6:1700060. [Content Brief]
[3]. Doffman SR, et al. AZD8630/AMG 104, an inhaled anti-thymic stromal lymphopoietin antibody fragment, for moderate-to-severe asthma: Phase 1 randomized controlled trial. The Journal of allergy and clinical immunology. 2026 Apr 20. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Sunakiment Related Classifications
HY-P991717 Related Classifications
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