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Cat. No.: HY-184372

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SIRT1-IN-7

SIRT1-IN-7 is a weak inhibitor of SIRT1 with an IC₅₀ > 100 μM. SIRT1-IN-7 can be used in cancer-related research, such as breast cancer research.

For research use only. We do not sell to patients.

CAS No.: 720672-18-4
Formula: C₁₇H₉FN₄O₂S
Molecular Weight:352.34

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

SIRT1-IN-7 Chemical Structure

CAS No.: 720672-18-4

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

SIRT1-IN-7 is a weak inhibitor of SIRT1 with an IC₅₀ > 100 μM. SIRT1-IN-7 can be used in cancer-related research, such as breast cancer research^[1].

IC₅₀ & Target^[1]

SIRT1

All Sirtuin Isoforms :

In Vitro

SIRT1-IN-7 (compound 27) exerts extremely weak inhibitory activity against purified SIRT1 enzyme, with an IC₅₀ greater than 100 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 720672-18-4
Molecular Weight 352.34
Formula C₁₇H₉FN₄O₂S
SMILES

FC1=CC=C(C2=CC=C(C3=NN4C(S3)=NN=C4C5=CC=CO5)O2)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Wu J, et al. Structure-activity relationship and interaction studies of new SIRT1 inhibitors with the scaffold of 3-(furan-2-yl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole. Bioorganic & medicinal chemistry letters. 2014 Jul 15;24(14):3050-6. [Content Brief]

Calculators

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Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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