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Solnerstotug

(Synonyms: SNS-101; SNA 101)
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Solnerstotug (SNS-101; SNA 101) is a pH-sensitive humanized IgG1κ antibody targeting VISTA. The affinity of Solnerstotug for VISTA decreases continuously with increasing pH, with KD values of 0.35 nM and 353 nM at pH 5.8 and pH 7.4, respectively. Solnerstotug reshapes the tumor microenvironment by selectively blocking the interaction of VISTA with receptors such as PSGL-1 (IC50 = 6.7 nM) in acidic environments, polarizing macrophages toward a pro-inflammatory M1-like phenotype and increasing intratumoral CD8+ T cell infiltration. Solnerstotug can be used for cancer research.

For research use only. We do not sell to patients.

  • Purity : 99.9%
  • CAS No.: 2927399-38-8
  • Molecular Weight:145.52 kDa
  • Storage:
    Shipping with dry ice

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Solnerstotug
  • Experimental Validation Results for Solnerstotug
  • Experimental Validation Results for Solnerstotug
  • Solnerstotug Chemical Structure
    Solnerstotug Chemical Structure
CAS No.: 2927399-38-8
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Solnerstotug Product Recommendations:

To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
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Assay Types
  • 1/16

    IgG1-kappa

  • 1/16

    Immobilized VISTA/B7-H5 Protein, Human (HEK293, Fc, HY-P77879) can bind Solnerstotug. The EC50 for this effect is 81.98 ng/mL.

  • 1/16

    Flow cytometric analysis of 1×106 Jurkat cells labelling B7-H5 (red) with Solnerstotug (HY-P991025). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa Isotype Control (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).

  • Solnerstotug Chemical Structure
    1/16
  • Solnerstotug
  • Immobilized VISTA/B7-H5 Protein, Human (HEK293, Fc, HY-P77879) can bind Solnerstotug. The EC50 for this effect is 81.98 ng/mL.
  • Flow cytometric analysis of 1×106 Jurkat cells labelling B7-H5 (red) with Solnerstotug (HY-P991025). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa Isotype Control (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).
  • IgG1-kappa