TAK-137 

TAK-137 is an AMPA receptor potentiator with weak agonistic effect. TAK-137 binds to the AMPA receptor ligand binding domain in a glutamate-dependent manner. TAK-137 potentiates AMPA-induced currents and Ca²⁺ influx. TAK-137 can be used for the research of neurological disease^[1].

TAK-137 (30 μM; 60 min) potentiates AMPA-induced Ca²⁺ influx in rat primary hippocampal neurons with an EC₅₀ of 0.42 μM and exhibits a 7.6% agonistic effect at 30 μM in the absence of AMPA^[1].
TAK-137 (30 μM) potentiates AMPA-induced currents in rat primary hippocampal neurons with an EC₅₀ of 1.4 μM and exhibits a 6.4% agonistic effect at 30 μM in the absence of AMPA^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

352.41

C₁₉H₁₆N₂O₃S

1358749-55-9

O=S1(=O)N=C2C(=CC=CN2CC1)C=3C=CC(OC=4C=CC=CC4)=CC3

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Suzuki A, et al. Strictly regulated agonist-dependent activation of AMPA-R is the key characteristic of TAK-653 for robust synaptic responses and cognitive improvement[J]. Scientific Reports, 2021, 11(1): 14532.  [Content Brief]