Acridone
Based on 1 Customer Validation
Acridone is an organic compound based on the acridine skeleton. Acridone has antibacterial, antimalarial, antiviral and anti neoplastic activities.
For research use only. We do not sell to patients.
- Purity: 99.89%
- CAS No.: 578-95-0
- Formula: C13H9NO
- Molecular Weight:195.22
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A2780 | IC50 |
>100 μM
Compound: 21
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Cytotoxic potency required to inhibit A2780 cell growth by 50% after cell drug contact for 96 hrs
Cytotoxic potency required to inhibit A2780 cell growth by 50% after cell drug contact for 96 hrs
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[PMID: 9371240] |
| CCRF-CEM | IC50 |
>100 μM
Compound: 1
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Antiproliferative activity against human CCRF-CEM cells after 48 hrs by MTT assay
Antiproliferative activity against human CCRF-CEM cells after 48 hrs by MTT assay
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[PMID: 18713666] |
| CH1 | IC50 |
77 μM
Compound: 21
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Cytotoxic potency required to inhibit CH1 cell growth by 50%
Cytotoxic potency required to inhibit CH1 cell growth by 50%
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[PMID: 9371240] |
| G-361 | IC50 |
>100 μM
Compound: 21
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Cytotoxic potency required to inhibit G-361 cell growth by 50%
Cytotoxic potency required to inhibit G-361 cell growth by 50%
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[PMID: 9371240] |
| HaCaT | IC50 |
>50 μM
Compound: 9a
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Antiproliferative activity against human HaCaT cells assessed as dispersed cells after 48 hrs by phase-contrast microscopic analysis
Antiproliferative activity against human HaCaT cells assessed as dispersed cells after 48 hrs by phase-contrast microscopic analysis
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[PMID: 20850910] |
| L1210 | IC50 |
>100 μM
Compound: 21
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Cytotoxic potency required to inhibit L1210 cell growth by 50% after cell drug contact for 48 hrs
Cytotoxic potency required to inhibit L1210 cell growth by 50% after cell drug contact for 48 hrs
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[PMID: 9371240] |
| SK-OV-3 | IC50 |
>100 μM
Compound: 21
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Cytotoxic potency required to inhibit SKOV-3 cell growth 50%
Cytotoxic potency required to inhibit SKOV-3 cell growth 50%
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[PMID: 9371240] |
Acridone (0.1-1 µM, 48 h) inhibits the proliferation of cancer cell MDA-MB-231, blocks the mRNA and protein expression of ATP binding cassette subfamily G member 2 (ABCG2)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MDA-MB-231
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Concentration:0.1-1 µM
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Incubation Time:48 h
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Result:Inhibited the proliferation.
Chemical Information
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CAS No. 578-95-0
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Appearance Solid
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Molecular Weight 195.22
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Formula C13H9NO
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Color Light yellow to green yellow
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SMILES
C1=C2C(=CC=C1)C(C3=C(N2)C=CC=C3)=O
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 25 mg/mL (128.06 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: 2.5 mg/mL (12.81 mM); Suspended solution; Need ultrasonic
This protocol yields a suspended solution of 2.5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: 2.5 mg/mL (12.81 mM); Suspended solution; Need ultrasonic
This protocol yields a suspended solution of 2.5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (275 KB)
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SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 5.1224 mL | 25.6120 mL | 51.2240 mL | 128.0600 mL |
| 5 mM | 1.0245 mL | 5.1224 mL | 10.2448 mL | 25.6120 mL | |
| 10 mM | 0.5122 mL | 2.5612 mL | 5.1224 mL | 12.8060 mL | |
| 15 mM | 0.3415 mL | 1.7075 mL | 3.4149 mL | 8.5373 mL | |
| 20 mM | 0.2561 mL | 1.2806 mL | 2.5612 mL | 6.4030 mL | |
| 25 mM | 0.2049 mL | 1.0245 mL | 2.0490 mL | 5.1224 mL | |
| 30 mM | 0.1707 mL | 0.8537 mL | 1.7075 mL | 4.2687 mL | |
| 40 mM | 0.1281 mL | 0.6403 mL | 1.2806 mL | 3.2015 mL | |
| 50 mM | 0.1024 mL | 0.5122 mL | 1.0245 mL | 2.5612 mL | |
| 60 mM | 0.0854 mL | 0.4269 mL | 0.8537 mL | 2.1343 mL | |
| 80 mM | 0.0640 mL | 0.3201 mL | 0.6403 mL | 1.6007 mL | |
| 100 mM | 0.0512 mL | 0.2561 mL | 0.5122 mL | 1.2806 mL |
Acridone Related Classifications
HY-W007771 Related Classifications
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