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Cat. No.: HY-N21666

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Micranoic acid B

Micranoic acid B is a terpenoid compound. Micranoic acid B exhibits cytotoxicity against cancer cells and shows comparable activity against multidrug-resistant and parental cancer cell lines. Micranoic acid B can be used for research on lung cancer, prostate cancer, and nasopharyngeal epidermoid carcinoma.

For research use only. We do not sell to patients.

CAS No.: 659738-09-7
Formula: C₂₂H₃₂O₃
Molecular Weight:344.50

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Micranoic acid B Chemical Structure

CAS No.: 659738-09-7

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

All Endogenous Metabolite Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	GI50	12.79 μM	Cytotoxicity against human lung carcinoma A549 cells assessed as 50% inhibition of cell growth incubated for 72 hrs by sulforhodamine B (SRB) colorimetric assay. Cytotoxicity against human lung carcinoma A549 cells assessed as 50% inhibition of cell growth incubated for 72 hrs by sulforhodamine B (SRB) colorimetric assay.	23883077
PC-3	GI50	11.83 μM	Cytotoxicity against human prostate carcinoma PC-3 cells assessed as 50% inhibition of cell growth incubated for 72 hrs by sulforhodamine B (SRB) colorimetric assay. Cytotoxicity against human prostate carcinoma PC-3 cells assessed as 50% inhibition of cell growth incubated for 72 hrs by sulforhodamine B (SRB) colorimetric assay.	23883077
KB	GI50	12.62 μM	Cytotoxicity against human epidermoid carcinoma of the nasopharynx KB cells assessed as 50% inhibition of cell growth incubated for 72 hrs by sulforhodamine B (SRB) colorimetric assay. Cytotoxicity against human epidermoid carcinoma of the nasopharynx KB cells assessed as 50% inhibition of cell growth incubated for 72 hrs by sulforhodamine B (SRB) colorimetric assay.	23883077

In Vitro

Micranoic acid B (compound 5) (72 h) exhibits moderate cytotoxicity against A549, PC-3, KB and KBvin human cancer cell lines with GI₅₀ values of 11.83-12.79 μM^[4].
Micranoic acid B (compound 93) is a norcycloartane triterpenoid isolated from Schisandra micrantha that features an octanortriterpenoid backbone lacking the entire C-17 side chain^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

CAS No. 659738-09-7
Molecular Weight 344.50
Formula C₂₂H₃₂O₃
SMILES

C(CC(O)=O)[C@]12[C@]3([C@]([C@@]4(C)[C@](C)(CC3)C(=O)CC4)(CC[C@H]1C(C)=C)[H])C2
Structure Classification
- Terpenoids
- Triterpenes
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Rao G, et al. α-Glucosidase and Bacterial β-Glucuronidase Inhibitors from the Stems of Schisandra sphaerandra Staph. Pharmaceuticals (Basel). 2022 Mar 9;15(3):329.

[2]. Xiao WL, et al. Triterpenoids from the Schisandraceae family. Natural product reports. 2008 Oct;25(5):871-91. [Content Brief]

[3]. Zou J, et al. Cycloartane triterpenoids from the stems of Schisandra glaucescens and their bioactivity. Fitoterapia. 2012 Jul;83(5):926-31.

[4]. Lu Y, et al. Cytotoxic and potential anticancer constituents from the stems of Schisandra pubescens. Pharmaceutical biology. 2013 Sep;51(9):1204-7. [Content Brief]

[5]. Shu L, et al. Rapid identification of chemical compositions of three species of Schisandra chinensis by ultra-high-performance liquid chromatography quadrupole-orbitrap-mass spectrometry. Journal of separation science. 2023 Oct;46(20):e2300466.

[6]. He F, et al. Nortriterpene constituents from Schisandra sphenanthera. Tetrahedron. 2012 Jan 14;68(2):440-6.

[7]. Li RT, et al. Micranoic acids A and B: two new octanortriterpenoids from Schisandra micrantha. Chemical & pharmaceutical bulletin. 2003 Oct;51(10):1174-6.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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