Curvularin
Based on 1 Customer Validation
Curvularin, a fungal metabolite and a potent mycotoxin naturally isolated from Curvularia lunata, inhibits cytokine-induced nitric oxide synthase (iNOS), with an IC50 of 9.5 µM.
For research use only. We do not sell to patients.
- Purity: 99.99%
- CAS No.: 10140-70-2
- Formula: C16H20O5
- Molecular Weight:292.33
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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iNOS |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HepG2 | IC50 |
34.2 μM
Compound: (S)-Curvularin
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Binding affinity to (AGCCAGACA)9-MLP element (unknown origin) transiently transfected in human HepG2 cells assessed as inhibition of TGF-beta-induced Smad-dependent transcriptional activity preincubated for 1 hr before TGF-beta stimulation measured after
Binding affinity to (AGCCAGACA)9-MLP element (unknown origin) transiently transfected in human HepG2 cells assessed as inhibition of TGF-beta-induced Smad-dependent transcriptional activity preincubated for 1 hr before TGF-beta stimulation measured after
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[PMID: 25537529] |
| HepG2 | IC50 |
86.4 μM
Compound: (S)-Curvularin
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Inhibition of TGF-beta-induced human CTGF promoter activity transiently transfected in human HepG2 cells after 16 hrs by luciferase reporter assay
Inhibition of TGF-beta-induced human CTGF promoter activity transiently transfected in human HepG2 cells after 16 hrs by luciferase reporter assay
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[PMID: 25537529] |
Chemical Information
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CAS No. 10140-70-2
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Appearance Solid
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Molecular Weight 292.33
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Formula C16H20O5
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Color White to off-white
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SMILES
O=C(O[C@@H](C)CCCCC1)CC2=CC(O)=CC(O)=C2C1=O
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Synonyms
(S)-Curvularin
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Structure Classification
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Initial Source
fungus Eupenicillium sp
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Purity & Documentation
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Data Sheet (271 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Kumar CG, et al. Metabolite profiling and biological activities of bioactive compounds produced by Chrysosporium lobatum strain BK-3 isolated from Kaziranga National Park, Assam, India. Springerplus. 2013 Dec;2(1):122. [Content Brief]
[2]. Yao Y, et al. Sporogen, S14-95, and S-curvularin, three inhibitors of human inducible nitric-oxide synthase expression isolated from fungi. Mol Pharmacol. 2003 Feb;63(2):383-91. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Curvularin Related Classifications
HY-N6770 Related Classifications
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