DOI hydrochloride
Based on 1 publication(s) in Google Scholar
DOI hydrochloride is a serotonin 5-HT2A/2C receptor agonist with Ki values of 0.7 nM, 2.4 nM and 20 nM for h5-HT2A, h5-HT2C and h5-HT2B receptors, respectively. DOI hydrochloride can across the blood-brain barrier. DOI hydrochloride increases head twitches in mice.
For research use only. We do not sell to patients.
- Purity: 99.6%
- CAS No.: 42203-78-1
- Formula: C11H17ClINO2
- Molecular Weight:357.62
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) DOI hydrochloride
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Customer Validation & Images
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In Vivo Efficacy Study
All 5-HT Receptor Isoforms
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Biological Activity
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5-HT2B Receptor |
5-HT2C Receptor |
Human 5-HT2A Receptor 0.7 nM (Ki) |
Human 5-HT2C Receptor 2.4 nM (Ki) |
human 5-HT2B Receptor 20 nM (Ki) |
DOI hydrochloride (10 μM; for 45 min) causes a massive increase in adhesion with 99% of the cells staying adherent compared to only 42% of untreated Hu2AAB1 cells[5].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
DOI (0.35-0.7 mmol/kg; sc) significantly increases waking and light sleep and reduces slow wave sleep, rapid-eye-movement (REM) sleep, and the number of REM periods in Male Wistar rats weighing 350-400 g[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 42203-78-1
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Appearance Solid
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Molecular Weight 357.62
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Formula C11H17ClINO2
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Color White to light yellow
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SMILES
NC(C)CC1=CC(OC)=C(I)C=C1OC.[H]Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (1)
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Journal Impact Factor
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Most Recent
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Biomed Pharmacother
Pharmacological effects of MT-1207 in bilateral renal artery stenosis hypertension and its hypotensive targets validation. [Abstract]2024 Aug 5:178:117234. PMID: 39106710
DOI hydrochloride purchased from MedChemExpress. Usage Cited in: Biomed Pharmacother. 2024 Aug 5:178:117234. [Abstract]
MT blocks DOI hydrochloride (3 mg/kg, iv, single dose)-induced BP elevation, as shown by systolic BP changes before and after DOI administration under pre-treatment of Vehicle or MT.
Solvent & Solubility
H2O : 25 mg/mL (69.91 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. D L Nelson, et al. Comparisons of hallucinogenic phenylisopropylamine binding affinities at cloned human 5-HT2A, -HT(2B) and 5-HT2C receptors. Naunyn Schmiedebergs Arch Pharmacol. 1999 Jan;359(1):1-6. [Content Brief]
[2]. S L Shepheard, et al. Investigation of the effects of IVth ventricular administration of the 5-HT2 agonist, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI), on autonomic outflow in the anaesthetized cat. Br J Pharmacol. 1991 Oct;104(2):367-72. [Content Brief]
[3]. Mark J Benvenga, et al. Metabotropic Glutamate 2 Receptors Play a Key Role in Modulating Head Twitches Induced by a Serotonergic Hallucinogen in Mice. Front Pharmacol. 2018 Mar 15;9:208. [Content Brief]
[4]. Jaime M Monti, et al. Effects of the serotonin 5-HT2A/2C receptor agonist DOI and of the selective 5-HT2A or 5-HT2C receptor antagonists EMD 281014 and SB-243213, respectively, on sleep and waking in the rat. Eur J Pharmacol. 2006 Dec 28;553(1-3):163-70. [Content Brief]
[5]. Joe Anand Kumar John Jayakumar, et al. Serotonin 2A (5-HT 2A) receptor affects cell-matrix adhesion and the formation and maintenance of stress fibers in HEK293 cells. Sci Rep. 2020 Dec 10;10(1):21675. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 2.7963 mL | 13.9813 mL | 27.9626 mL | 69.9066 mL |
| 5 mM | 0.5593 mL | 2.7963 mL | 5.5925 mL | 13.9813 mL | |
| 10 mM | 0.2796 mL | 1.3981 mL | 2.7963 mL | 6.9907 mL | |
| 15 mM | 0.1864 mL | 0.9321 mL | 1.8642 mL | 4.6604 mL | |
| 20 mM | 0.1398 mL | 0.6991 mL | 1.3981 mL | 3.4953 mL | |
| 25 mM | 0.1119 mL | 0.5593 mL | 1.1185 mL | 2.7963 mL | |
| 30 mM | 0.0932 mL | 0.4660 mL | 0.9321 mL | 2.3302 mL | |
| 40 mM | 0.0699 mL | 0.3495 mL | 0.6991 mL | 1.7477 mL | |
| 50 mM | 0.0559 mL | 0.2796 mL | 0.5593 mL | 1.3981 mL | |
| 60 mM | 0.0466 mL | 0.2330 mL | 0.4660 mL | 1.1651 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
DOI hydrochloride Related Classifications
HY-103124 Related Classifications
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