NFKB1 - nuclear factor kappa B subunit 1 Gene

Also Known as KBF1; EBP-1; NF-kB; CVID12; NF-kB1; NFKB-p50; NFkappaB; NF-kappaB; NFKB-p105; NF-kappa-B1; NF-kappabeta

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 4790

About NFKB1

Cytogenetic location: 4q24 Genomic coordinates (GRCh38): 4:102,501,359-102,617,302 (from NCBI)

This gene has 25 transcripts (splice variants), 204 orthologues, 4 paralogues and is associated with 2 phenotypes. Ubiquitous expression in bone marrow (RPKM 27.7), appendix (RPKM 20.3) and 25 other tissues.

Summary

This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S Proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and Bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. NFKB is a critical regulator of the immediate-early response to viral Infection. Alternative splicing results in multiple transcript variants encoding different isoforms, at least one of which is proteolytically processed. [provided by RefSeq, Aug 2020]

NFKB1 Products (12)

mRNA	Protein	Name
NM_001382626.1	NP_001369555.1	nuclear factor NF-kappa-B p105 subunit isoform 1
NM_001382625.1	NP_001369554.1	nuclear factor NF-kappa-B p105 subunit isoform 1
NM_001382627.1	NP_001369556.1	nuclear factor NF-kappa-B p105 subunit isoform 2 proprotein
XM_024454069.2	XP_024309837.1	nuclear factor NF-kappa-B p105 subunit isoform X2
NM_001382628.1	NP_001369557.1	nuclear factor NF-kappa-B p105 subunit isoform 3
NM_001319226.2	NP_001306155.1	nuclear factor NF-kappa-B p105 subunit isoform 2 proprotein
XM_047415744.1	XP_047271700.1	nuclear factor NF-kappa-B p105 subunit isoform X3
XM_024454068.1	XP_024309836.1	nuclear factor NF-kappa-B p105 subunit isoform X1
NM_001165412.2	NP_001158884.1	nuclear factor NF-kappa-B p105 subunit isoform 2 proprotein
XM_047415743.1	XP_047271699.1	nuclear factor NF-kappa-B p105 subunit isoform X3
XM_047415742.1	XP_047271698.1	nuclear factor NF-kappa-B p105 subunit isoform X1
NM_003998.4	NP_003989.2	nuclear factor NF-kappa-B p105 subunit isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	1406630	GOA
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	8413223	GOA
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	17426251	GOA
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IMP IMP: Inferred from mutant phenotype	26801246	GOA
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	24434510	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	1406630	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IMP IMP: Inferred from mutant phenotype	26801246	GOA
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	7959007	GOA
enables actinin binding	IPI IPI: Inferred from physical interaction	25411248	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	12482991	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	7651415	GOA
enables protein sequestering activity	IDA IDA: Inferred from direct assay	1423592	GOA
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	16938301	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in antibacterial innate immune response	IDA IDA: Inferred from direct assay	20406817	GOA
involved in canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	23811396	GOA
involved in cellular response to angiotensin	IMP IMP: Inferred from mutant phenotype	22357537	GOA
involved in cellular response to interleukin-1	IEP IEP: Inferred from expression pattern	12958148	GOA
involved in cellular response to interleukin-6	IMP IMP: Inferred from mutant phenotype	22357537	GOA
acts upstream of or within cellular response to lipopolysaccharide	IMP IMP: Inferred from mutant phenotype	23776175	GOA
involved in cellular response to mechanical stimulus	IEP IEP: Inferred from expression pattern	19593445	GOA
involved in cellular response to nicotine	IMP IMP: Inferred from mutant phenotype	22357537	GOA
involved in negative regulation of calcidiol 1-monooxygenase activity	IDA IDA: Inferred from direct assay	15243130	GOA
involved in negative regulation of gene expression	IDA IDA: Inferred from direct assay	26687115	GOA
involved in negative regulation of inflammatory response	IDA IDA: Inferred from direct assay	16424369	GOA
acts upstream of or within negative regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	24434150	GOA
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	19881551	GOA
involved in non-canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	8413223	GOA
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	17426251	GOA
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	20018240	GOA
involved in positive regulation of canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	20018240	GOA
involved in positive regulation of hyaluronan biosynthetic process	IDA IDA: Inferred from direct assay	17324121	GOA
involved in positive regulation of miRNA metabolic process	IMP IMP: Inferred from mutant phenotype	22357537	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	1406630	GOA
acts upstream of or within positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	19955433	GOA
involved in regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	34721373	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in chromatin	IDA IDA: Inferred from direct assay	8413223	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	11819787	GOA
located in cytoplasm	IGI IGI: Inferred from genetic interaction	23729669	GOA
located in nucleus	IDA IDA: Inferred from direct assay	11819787	GOA
located in nucleus	IGI IGI: Inferred from genetic interaction	23729669	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NFKB1 Protein Structure

RHD_DNA_bind

Ank_2

Ank

Death

0
200
400
600
800
968 a.a.

Protein Preferred Names	Protein Names
nuclear factor NF-kappa-B p105 subunit	DNA-binding factor KBF1 nuclear factor NF-kappa-B p50 subunit nuclear factor kappa-B DNA binding subunit nuclear factor of kappa light polypeptide gene enhancer in B-cells 1

NFKB1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	NFKB1	P19838	COPB2	Homo sapiens	P35606	BioID	35140242
Intra	NFKB1	P19838	COPB2	Homo sapiens	P35606	Affinity Chrom	35140242
Intra	NFKB1	P19838	COPB2	Homo sapiens	P35606	TAP	25609649
Intra	NFKB1	P19838	MAP3K8	Homo sapiens	P41279	TAP	14743216
Intra	NFKB1	P19838	NFKBIA	Homo sapiens	P25963	Anti Tag CoIP	35271311
Intra	NFKB1	P19838	MAP3K8	Homo sapiens	P41279	SPR	12832462
Intra	NFKB1	P19838	MAP3K8	Homo sapiens	P41279	Enzymatic Footprint	12832462
Intra	NFKB1	P19838	MAP3K8	Homo sapiens	P41279	Anti Tag CoIP	12832462
Intra	NFKB1	P19838	NFKBIA	Homo sapiens	P25963	BioID	35140242
Intra	NFKB1	P19838	MAP3K8	Homo sapiens	P41279	ITC	12832462
Intra	NFKB1	P19838	MAP3K8	Homo sapiens	P41279	Affinity Chrom	35140242
Intra	NFKB1	P19838	NFKBIA	Homo sapiens	P25963	Affinity Chrom	35140242
Intra	NFKB1	P19838	MAP3K8	Homo sapiens	P41279	Pull Down	12832462
Intra	NFKB1	P19838	NFKBIA	Homo sapiens	P25963	Y2H	21988832
Intra	NFKB1	P19838	MAP3K8	Homo sapiens	P41279	TAP	25609649
Intra	NFKB1	P19838	NFKBIA	Homo sapiens	P25963	TAP	14743216
Intra	NFKB1	P19838	NFKBIA	Homo sapiens	P25963	TAP	25609649
Intra	NFKB1	P19838	PDCD11	Homo sapiens	Q14690	Y2H	14624448
Intra	NFKB1	P19838	HDAC1	Homo sapiens	Q13547	Anti Bait CoIP	11931769
Intra	NFKB1	P19838	HDAC1	Homo sapiens	Q13547	Pull Down	11931769
Intra	NFKB1	P19838	NFKB2	Homo sapiens	Q00653	TAP	25609649
Intra	NFKB1	P19838	NFKB2	Homo sapiens	Q00653	Anti Tag CoIP	35271311
Intra	NFKB1	P19838	NFKB2	Homo sapiens	Q00653	BioID	35140242
Intra	NFKB1	P19838	NFKB2	Homo sapiens	Q00653	Affinity Chrom	35140242
Intra	NFKB1	P19838	NFKB2	Homo sapiens	Q00653	TAP	14743216
Intra	NFKB1	P19838	RPS3	Homo sapiens	P23396	Anti Bait CoIP	18045535
Intra	NFKB1	P19838	RPS3	Homo sapiens	P23396	TAP	25609649
Intra	NFKB1	P19838	NFKBIB	Homo sapiens	Q15653	Anti Tag CoIP	35271311
Intra	NFKB1	P19838	NFKBIB	Homo sapiens	Q15653	TAP	14743216
Intra	NFKB1	P19838	NFKBIB	Homo sapiens	Q15653	BioID	35140242
Intra	NFKB1	P19838	NFKBIB	Homo sapiens	Q15653	Affinity Chrom	35140242
Intra	NFKB1	P19838	RELB	Homo sapiens	Q01201	TAP	25609649
Intra	NFKB1	P19838	RELB	Homo sapiens	Q01201	Anti Tag CoIP	35271311
Intra	NFKB1	P19838	RELB	Homo sapiens	Q01201	BioID	35140242
Intra	NFKB1	P19838	RELB	Homo sapiens	Q01201	Affinity Chrom	35140242
Intra	NFKB1	P19838	RELB	Homo sapiens	Q01201	TAP	14743216
Intra	NFKB1	P19838	TNIP1	Homo sapiens	Q15025	Y2H	21988832
Intra	NFKB1	P19838	TNIP1	Homo sapiens	Q15025	TAP	25609649
Intra	NFKB1	P19838	TNIP1	Homo sapiens	Q15025	BioID	35140242
Intra	NFKB1	P19838	TNIP2	Homo sapiens	Q8NFZ5	Y2H	21988832
Intra	NFKB1	P19838	TNIP2	Homo sapiens	Q8NFZ5	TAP	25609649
Intra	NFKB1	P19838	TNIP2	Homo sapiens	Q8NFZ5	BioID	35140242
Intra	NFKB1	P19838	TNIP2	Homo sapiens	Q8NFZ5	Affinity Chrom	35140242
Intra	NFKB1	P19838	ABCC2	Homo sapiens	Q92887	Y2H	21988832
Intra	NFKB1	P19838	ABCC2	Homo sapiens	Q92887	Anti Tag CoIP	21988832
Intra	NFKB1	P19838	CTNNB1	Homo sapiens	P35222	Pull Down	19358846
Intra	NFKB1	P19838	RELA	Homo sapiens	Q04206	Anti Tag CoIP	35271311
Intra	NFKB1	P19838	RELA	Homo sapiens	Q04206	BioID	35140242
Intra	NFKB1	P19838	RELA	Homo sapiens	Q04206	Y2H	10498867
Intra	NFKB1	P19838	RELA	Homo sapiens	Q04206	Affinity Chrom	35140242
Intra	NFKB1	P19838	RELA	Homo sapiens	Q04206	TAP	25609649
Intra	NFKB1	P19838	RELA	Homo sapiens	Q04206	Anti Bait CoIP	20547752
Intra	NFKB1	P19838	HIF1AN	Homo sapiens	Q9NWT6	Anti Tag CoIP	17003112
Intra	NFKB1	P19838	HIF1AN	Homo sapiens	Q9NWT6	TAP	25609649
Intra	NFKB1	P19838	HIF1AN	Homo sapiens	Q9NWT6	Anti Bait CoIP	17003112
Intra	NFKB1	P19838	CHUK	Homo sapiens	O15111	Anti Tag CoIP	35271311
Intra	NFKB1	P19838	CHUK	Homo sapiens	O15111	TAP	25609649
Intra	NFKB1	P19838	CHUK	Homo sapiens	O15111	Protein Kinase Assay	11297557
Intra	NFKB1	P19838	IKBKB	Homo sapiens	O14920	Protein Kinase Assay	11297557
Intra	NFKB1	P19838	IKBKB	Homo sapiens	O14920	Anti Tag CoIP	35271311
Cross	NFKB1	P19838	pap_hhv11	Human herpesvirus 1	P10226	Anti Tag CoIP	23636254

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant NFKB1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71124	NFKB1 Protein, Human (His)	P19838-2 (M1-G434)	≥ 95%, as determined by reducing SDS-PAGE.

NFKB1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80244	NF-KB p105/p50 Antibody (YA699)	WB, ICC/IF, IHC-P	Human, Mouse
HY-P80764	NF-KB p105/p50 Antibody (YA700)	WB	Human, Mouse, Rat
HY-P81049	Phospho-NF-KB p105/p50(Ser337) Antibody	WB, IHC-P, IHC-F, FC, ICC/IF, ELISA	Human, Mouse
HY-P85639	NF-KB p105/p50 Antibody (YA5331)	WB	Human
HY-P86373	NF-κB1 p105/p50 Antibody (YA6065)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Burkitt Lymphoma	Burkitt'S Lymphoma BL Burkitt Lymphoma, Somatic Burkitt Lymphoma/Leukaemia Burkitt'S Tumor Burkitt'S Tumor Or Lymphoma Malignant Lymphoma, Burkitt'S Type Small Non-Cleaved Cell Lymphoma, Burkitt'S Type Small Non-Cleaved Cell Lymphoma Burkitt Tumor Burkitts Lymphoma Lymphoma, Small Noncleaved-Cell Burkitt Tumour Diffuse Small Noncleaved Malignant Burkitt Lymphoma Malignant Burkitt Lymphoma “Burkitt-Like” Lymphoma Undifferentiated Burkitt Lymphoma Small Noncleaved Cell Burkitt Lymphoma
Huntington Disease	Huntington'S Disease Huntington Chorea HD Huntington'S Chorea Huntington Chronic Progressive Hereditary Chorea Juvenile Huntington Disease Chronic Progressive Chorea Chronic Progressive Hereditary Chorea Hc - [Huntington Chorea] Hereditary Chorea Progressive Hereditary Chorea
Incontinentia Pigmenti	Bloch-Sulzberger Syndrome IP Incontinentia Pigmenti, Familial Male-Lethal Type Incontinentia Pigmenti Syndrome Bloch-Siemens Syndrome Ip2 Incontinentia Pigmenti, Type Ii, Formerly Ip2, Formerly Incontinentia Pigmenti Type 2 Bloch-Siemens-Sulzberger Syndrome Familial Incontinentia Pigmenti Male-Lethal Type Familial Incontinentia Pigmenti Type Ii Incontinentia Pigmenti, Type Ii Bloch Sulzberger Syndrome Incontinentia Pigmenti Achromians Incontinentia Pigmenti Of Bloch-Sulzberger Nevus Pigmentosus Systematicus
Prion Disease	Spongiform Encephalopathy Transmissible Spongiform Encephalopathies Prion Diseases Prion Disease Pathway Transmissible Spongiform Encephalopathy Prion Induced Disorder Prion Protein Disease Inherited Human Transmissible Spongiform Encephalopathies Prion Protein Diseases Prion-Associated Disorders Prion-Induced Disorders Transmissible Dementias Tses Human Prion Disease Tse Encephalopathy, Transmissible Spongiform Prion Disease, Susceptibility To Spongiform Encephalopathies Human Transmissible Spongiform Encephalopathies, Inherited
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour
Measles	Rubeola Morbilli Measles Nos Koplik Spots
Breast Cancer	Breast Carcinoma Breast Cancer, Familial Malignant Neoplasm Of Breast Male Breast Cancer Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Osteopetrosis	Albers-Schonberg Disease Marble Bone Disease Osteopetroses Marble Bones Osteopetrosis And Related Disorders Congenital Osteopetrosis Marble Bone Albers-Schoenberg Disease Albers-Schonberg Osteopetrosis Osteosclerosis Fragilis Ivory Bones
Newcastle Disease	Newcastle'S Disease Pseudo-Fowlpest
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Protection Against Lung Cancer, Susceptibility To Adenocarcinoma Of Lung, Somatic Nonsmall Cell Lung Cancer Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Ulcerative Colitis	Colitis Gravis Left Sided Ulcerative Colitis Left-Sided Ulcerative Colitis Idiopathic Proctocolitis Inflammatory Bowel Disease, Ulcerative Colitis Type Uc Colitis Ulcerative Colitis, Ulcerative Chronic Left-Sided Ulcerative Colitis Uc - [Ulcerative Colitis] Chronic Ulcerative Enteritis Mucosal Proctocolitis Ulcerative Mucosal Proctocolitis Left Hemicolitis
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Cancer Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Oligospermia
Diabetes Mellitus	Diabetes
Immunodeficiency 12	Combined Immunodeficiency Due To Malt1 Deficiency IMD12 Immunodeficiency, Type 12
Endometrial Cancer	Endometrial Carcinoma Endometrial Neoplasm Malignant Neoplasm Of Endometrium Endometrioid Carcinoma Endometrial Neoplasms Carcinoma, Endometrioid Endometrial Cancer, Familial Endometrial Carcinoma, Somatic Endometrial Cancer, Susceptibility To Endometrial Ca Malignant Endometrial Neoplasm Neoplasm Of Endometrium Primary Malignant Neoplasm Of Endometrium Tumor Of Endometrium Carcinoma Of The Endometrium Endometrioid Carcinoma Of Female Reproductive System ENDMC Carcinoma Endometrioid Endometrial Cancers Cancer, Endometrial Uterine Corpus Cancer
Intestinal Perforation	Perforation Of Intestine
Microcephaly	Microencephaly Microcephalus Microcephalic Nanocephaly Congenital Microcephaly Brain Hypoplasia Brain Nondevelopment Cephalic Hypoplasia Undeveloped Cerebrum Undeveloped Brain Micrencephalon Micrencephaly
Alcohol Dependence	Alcoholism Alcohol Dependence, Susceptibility To Aerodigestive Tract Cancer, Squamous Cell, Alcohol-Related, Protection Against Alcohol Dependence, Protection Against Alcoholism, Susceptibility To Alcoholic Intoxication, Chronic Pharyngeal Neoplasms Chronic Alcoholism Dipsomania Alcohol Addiction Ethanol Dependence Chronic Ethanolism Chronic Alcoholic Disease Nos Alcoholic Disease Nos Alcoholic
Inflammatory Bowel Disease	Inflammatory Bowel Diseases Bowel Disease, Inflammatory
Common Variable Immunodeficiency	Cvid Common Variable Agammaglobulinemia Acquired Hypogammaglobulinemia Common Variable Immune Deficiency Hypogamma-Globulinemia, Acquired Idiopathic Immunoglobulin Deficiency Primary Antibody Deficiency Primary Hypogammaglobulinemia Acquired Agammaglobulinemia Sporadic Hypogammaglobulinemia Common Variable Hypogamma-Globulinemia Immunoglobulin Deficiency, Late-Onset Common Variable Hypogammaglobulinemia Immunodeficiency, Common Variable
Pancreatic Cancer	Pancreatic Carcinoma Familial Pancreatic Carcinoma Pancreatic Neoplasm Carcinoma Of Pancreas Pancreatic Carcinoma, Familial Malignant Neoplasm Of Pancreas Pancreatic Acinar Carcinoma Pancreatic Tumor Familial Pancreatic Cancer Neoplasm Of The Pancreas Pancreatic Carcinoma, Somatic Pancreatic Cancer, Somatic Ca Body Of Pancreas Ca Head Of Pancreas Ca Tail Of Pancreas Malignant Neoplasm Of Body Of Pancreas Malignant Neoplasm Of Head Of Pancreas Malignant Neoplasm Of Tail Of Pancreas Pancreas Neoplasm Exocrine Cancer Exocrine Pancreas Carcinoma Hereditary Pancreatic Cancer Hereditary Pancreatic Carcinoma PNCA Cancer Of The Pancreas Pancreatic Cancer, Susceptibility To Carcinoma Of Head Of Pancreas Pancreatic Neoplasms Pancreatic Tumors Cancer, Pancreatic Cancer Of Pancreas Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Ectodermal Dysplasia	Congenital Ectodermal Defect Congenital Ectodermal Dysplasia Ectodermal Dysplasia Syndrome Dysplasia, Ectodermal
Covid-19	2019 Novel Coronavirus 2019-Ncov Infection Covid19 Sars-Cov-2 Infection Wuhan Coronavirus Infection Wuhan Seafood Market Pneumonia Virus Infection
B-Cell Lymphoma	Lymphoma, B-Cell B-Cell Lymphomas B-Cell Lymphocytic Neoplasm Lymphoma B-Cell B-Cell Lymphoma Nos
Combined Immunodeficiency	Combined T Cell And B Cell Immunodeficiency Congenital Combined Immunodeficiency Syndrome With Combined Immunodeficiency Combined T And B Cell Immunodeficiency Combined Immunity Deficiency Combined Immunodeficiency Syndrome Combined T-Cell And B-Cell Immunodeficiency Lymphopenic Agammaglobulinaemia
Immunodeficiency, Common Variable, 12, With Autoimmunity	Immunodeficiency, Common Variable, 12 CVID12 Nfkb1 Deficiency
Esophageal Tuberculosis	Tuberculosis Of Esophagus
Squamous Cell Carcinoma	Epidermoid Carcinoma Squamous Cell Cancer Carcinoma, Squamous Cell Malignant Squamous Cell Tumor Squamous Carcinoma Squamous Cell Epithelioma Squamous Cell Skin Cancer Carcinoma Squamous Cell Neoplasms, Squamous Cell Squamous Cell Carcinoma - Category Malignant Squamous Cell Neoplasm Squamous Cell Carcinoma Of Skin
Heart Disease	Heart Failure Congenital Heart Disease Heart Diseases Congenital Heart Defects Congenital Heart Defect Congenital Anomaly Of Heart Heart Defect Heart Malformation Heart-Congenital Defect Congenital Heart Disorder Heart Defects Congenital Heart Defects, Congenital Heart Defects Heart Disease, Congenital Disease, Heart, Congenital Congestive Heart Failure
Rabies	Lyssa Hydrophobia St Hubert Disease
Aging
T-Cell Acute Lymphoblastic Leukemia	T-Cell Leukemia Acute T Cell Leukemia Precursor T Lymphoblastic Leukemia Precursor T-Lymphoblastic Lymphoma/Leukemia T Acute Lymphoblastic Leukemia T-Cell Acute Lymphocytic Leukaemia T-Cell Lymphoblastic Leukemia/Lymphoma Leukemia T-Cell Leukemia, T-Cell Leukemia, Acute, Lymphoblastic, T-Cell Leukemia, T-Cell Acute Lymphoblastic Leukemia, Acute T-Cell Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Precursor T-Cell Lymphoblastic Lymphoma Precursor T Cell Lymphoblastic Leukemia/Lymphoblastic Lymphoma
Colitis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Pre-clinical Phase

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-19696B	Tauroursodeoxycholate dihydrate		99.96%	Yes

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P9928	Alirocumab	Inhibitor	97.00%	Unkown

Pre-clinical Phase

Bioactive Molecules (21)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N0535	(+)-Magnoflorine chloride		99.29%	Unkown
HY-N7922	Urolithin M5	Inhibitor	97.31%	Unkown
HY-133987	AP-1/NF-κB activation inhibitor 1	Inhibitor	98.08%	Unkown
HY-152177	JS6	Inhibitor	99.49%	Unkown
HY-N0334A	(+)-Magnoflorine iodide		99.74%	Unkown
HY-N1508	Ecliptasaponin A		99.81%	Unkown
HY-49444	EN450	Degrader	98.59%	Unkown
HY-N7627	Regaloside C		99.62%	Unkown
HY-174138	NF-κB degrader 1	Degrader	99.92%	Unkown
HY-N0772	Isomangiferin		99.60%	Unkown
HY-RS09254	NFKB1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-N3532	Cannabisin F	Modulator	96.0%	Unkown
HY-N0334	(+)-Magnoflorine		/	Unkown
HY-180580	SMU-C409		/	Unkown
HY-184654	MR-39		/	Unkown
HY-P5762A	Phoenixin-14 TFA		/	Unkown
HY-RS09255	Nfkb1 Mouse Pre-designed siRNA Set A		/	Unkown
HY-RS09256	Nfkb1 Rat Pre-designed siRNA Set A		/	Unkown
HY-W995241	BPD	Inhibitor	/	Unkown
HY-174569	Human NFKB1 mRNA		/	Unkown
HY-N15315	Triptriolide		/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P9928A	Alirocumab (anti-PCSK9)	Inhibitor	98.24%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	NFKB1	VGNC	VGNC:75339
Rattus norvegicus	NFKB1	RGD	RGD:70498
Bos taurus	NFKB1	VGNC	VGNC:32043
Canis familiaris	NFKB1	VGNC	VGNC:43780
Mus musculus	NFKB1	MGD	MGI:97312
Felis catus	NFKB1	VGNC	VGNC:68481
Others	NFKB1	NCBI