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Cat. No.: HY-116610

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L 748780

L 748780 (compound 2) is a selectivity COX-2 inhibitor with the IC₅₀ values of 0.5 μM and ＞ 100 μM for COX-2 and COX-1, respectively.

For research use only. We do not sell to patients.

CAS No.: 168086-64-4
Formula: C₁₉H₁₄Cl₃NO₄
Molecular Weight:426.68

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

L 748780 Chemical Structure

CAS No.: 168086-64-4

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

L 748780 (compound 2) is a selectivity COX-2 inhibitor with the IC₅₀ values of 0.5 μM and ＞ 100 μM for COX-2 and COX-1, respectively^[1].

IC₅₀ & Target

COX-2

0.5 μM (IC₅₀)

COX-1

> 100 μM (IC₅₀)

All COX Isoforms :

Chemical Information

CAS No. 168086-64-4
Molecular Weight 426.68
Formula C₁₉H₁₄Cl₃NO₄
SMILES

O=C(CC1=C(C)N(C(C2=C(Cl)C=C(Cl)C=C2Cl)=O)C3=C1C=C(C=C3)OC)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Lau CK, et al. From indomethacin to a selective COX-2 inhibitor. Development of indolalkanoic acids as potent and selective cyclooxygenase-2 inhibitors. Adv Exp Med Biol. 1997;407:73-8. PMID: 9321934. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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L 748780

All COX Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

L 748780 Related Classifications

HY-116610 Related Classifications