SR8185
SR8185 is a potent and selective TBK1/IKKi dual inhibitor with IC50s of 3 nM and < 10 nM against IKKi and TBK1, respectively. SR8185 exhibits potent and broad spectrum antiproliferative effects on human cancer cells. SR8185 can be used for cancer research.
For research use only. We do not sell to patients.
- CAS No.: 1356225-62-1
- Formula: C26H27N7O
- Molecular Weight:453.54
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
IKKi 3 nM (IC50) |
TBK1 <10 nM (IC50) |
In Vitro
SR8185 (72 h) exhibits potent and broad spectrum antiproliferative activity against a panel of human cancer cells, with IC50s of 1.901 (SCC-9), 0.651 (SCC-15), 1.641 (SCC-25), 0.611 (PC3), 0.532 (DU145),0.550 (LNCaP), 0.463 (Myc-CaP), 0.541 (MCF-7), 1.772 (MDA-MB-231), and 0.613 µM (T-47D), respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 1356225-62-1
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Molecular Weight 453.54
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Formula C26H27N7O
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SMILES
O=C(N1CCCC1)NC2=CC=CC(NC3=NC=CC(C4=CC=C(N5CCCC5)C(C#N)=C4)=N3)=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Viability Determination by MTT Colorimetric Assay
The following protocol uses the MTT colorimetric assay as a classic literature-established method for assessing cell viability/metabolic activity in cultured mammalian cells. MTT[3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] is reduced by metabolically active cells to a colored formazan product; the amount of formazan is quantified spectrophotometrically and provides an indirect measure of metabolically active viable cells. Importantly, MTT reduction reflects cellular oxidoreductase/metabolic activity rather than an absolute direct count of living cells, so changes in cellular metabolism can alter the signal independently of cell number.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SR8185 Related Classifications
HY-148483 Related Classifications
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