1. Terpenoids and Glycosides
  2. Valepotriate

Valepotriate (Synonyms: Valtrate)

Cat. No.: HY-N0718
Handling Instructions

Valepotriate, isolated from Valeriana jatamansi Jones, has anti-epileptic and anti-cancer activities.

For research use only. We do not sell to patients.

Valepotriate Chemical Structure

Valepotriate Chemical Structure

CAS No. : 18296-44-1

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5 mg USD 198 Ask For Quote & Lead Time
10 mg USD 336 Ask For Quote & Lead Time
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Description

Valepotriate, isolated from Valeriana jatamansi Jones, has anti-epileptic and anti-cancer activities[1][2].

In Vivo

Valepotriate showed significant anti-epileptic activity against MES- and PTZ-induced epilepsy at doses of 5, 10, and 20 mg/kg, and ED50 values for MES- and PTZ-induced epilepsy were 7.84 and 7.19 mg/kg, respectively. Furthermore, valepotriate (10 and 20 mg/kg) can significantly prolong sleeping time and shorten the latency time on the pentobarbital sodium-induced sleeping time test. Furthermore, valepotriate (5, 10, and 20 mg/kg) could significantly up-regulate the expression of GABAA, GAD65, and Bcl-2 and down-regulate the expression of caspase-3, but had no significant effect on the expression of GABAB[2].

Molecular Weight

422.47

Formula

C₂₂H₃₀O₈

CAS No.

18296-44-1

SMILES

O=C(CC(C)C)O[[email protected]@H]1[[email protected]]2(CO2)[[email protected]]([[email protected]@H]3OC(CC(C)C)=O)([H])C(C(COC(C)=O)=CO3)=C1

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

ValepotriateValtrateOthersanti-epilepticGABAAcancerapoptosissleepInhibitorinhibitorinhibit

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