Voxalatamab
Based on 1 Customer Validation
Voxalatamab (JNJ-63898081) is a bispecific IgG4 antibody targeting PSMA and CD3. Voxalatamab attacks PSMA-expressing tumor cells by activating T cells. Voxalatamab has anticancer activity and is being studied for the treatment of solid tumors such as prostate cancer.
For research use only. We do not sell to patients.
- Purity: 99.90%
- CAS No.: 2411871-58-2
- Molecular Weight:144.68 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
Human IgG4 kappa
Human
CD3E & FOLH1
Voxalatamab can bind to PSMA-expressing tumor cells and CD3-expressing T cells to overcome immunosuppression and promote antitumor activity[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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Ig(G4-kappa_G4-lambda2)
ELISA, FACS, Functional assay
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Immobilized Human CD3 epsilon/CD3e Protein (ECD, His Tag) can bind Voxalatamab. The EC50 for this effect is 4.79 ng/mL. -
Immobilized Human PSMA/FOLH1 Protein can bind Voxalatamab. The EC50 for this effect is 47.87 ng/mL. -
Flow cytometric analysis of 1×106 Jurkat cells labelling CD3E (red) with Voxalatamab (HY-P99517). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG4 kappa Isotype Control (HY-P99003, blue) was used as the isotype control.
Chemical Information
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CAS No. 2411871-58-2
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Appearance Liquid
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Molecular Weight 144.68 kDa
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Color Colorless to light yellow
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SMILES
[Voxalatamab]
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Synonyms
JNJ-63898081; JNJ-081
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Shipping
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (256 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
[1]. Lim EA, et al. Phase 1 Study of Safety and Preliminary Clinical Activity of JNJ-63898081, a PSMA and CD3 Bispecific Antibody, for Metastatic Castration-Resistant Prostate Cancer. Clin Genitourin Cancer. 2023 Jun;21(3):366-375. [Content Brief]
[2]. Jonas S Heitmann, et al. Bispecific Antibodies in Prostate Cancer Therapy: Current Status and Perspectives. Cancers (Basel). 2021 Feb 1;13(3):549. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)