WR 146459
Based on 1 Customer Validation
WR 146459 is an orally active 9-phenanthrenecarbinol and antimalarial agent. WR 146459 bears a 2-piperidyl substituent on its 9-carbinol moiety. WR 146459 inhibits hypoxanthine uptake by Plasmodium falciparum strains, reducing parasite viability. WR 146459 can be used for the research of malaria.
For research use only. We do not sell to patients.
- CAS No.: 50665-54-8
- Formula: C21H18Cl2F3NO
- Molecular Weight:428.27
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All Parasite Isoforms
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Biological Activity
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Plasmodium falciparum sporozoites |
WR 146459 (13.55-135.5 ng/mL) potently inhibits growth of Chloroquine (HY-17589A)-sensitive Plasmodium falciparum (Camp strain) with an ID50 of 2.14 ng/mL and Chloroquine-resistant Plasmodium falciparum (Smith strain) with an ID50 of 1.41 ng/mL in hypoxanthine uptake assay[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 50665-54-8
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Appearance Solid
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Molecular Weight 428.27
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Formula C21H18Cl2F3NO
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SMILES
OC(C1=CC2=C(C3=CC(C(F)(F)F)=CC=C13)C=C(Cl)C=C2Cl)C4CCCCN4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 2.5 mg/mL (5.84 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.3350 mL | 11.6749 mL | 23.3498 mL | 58.3744 mL |
| 5 mM | 0.4670 mL | 2.3350 mL | 4.6700 mL | 11.6749 mL |
WR 146459 Related Classifications
HY-185218 Related Classifications
Powered by Bioz
- WR 146459
- 50665-54-8
- WR146459
- WR-146459
- Parasite
- owl monkey
- chloroquine-resistant Plasmodium falciparum (Smith strain)
- ICR/HA Swiss mice
- parasite viability
- Plasmodium berghei
- Plasmodium falciparum
- antimalarial agent
- malaria
- hypoxanthine uptake
- chloroquine-sensitive Plasmodium falciparum (Camp strain)
- Inhibitor
- inhibitor
- inhibit