α-Epibromide
α-Epibromide (16α-Bromoepiandrosterone) is an adrenal steroid derivative. α-Epibromide decreases nitric oxide production. α-Epibromide restores T helper cell type 1 activity and accelerates chemotherapy-induced bacterial clearance in a model of progressive pulmonary tuberculosis. α-Epibromide reduces mortality related to excessive inflammation and opportunistic lung infections.
For research use only. We do not sell to patients.
- CAS No.: 28507-02-0
- Formula: C19H29BrO2
- Molecular Weight:369.34
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| H9c2 | EC50 |
13 μM
Compound: 3; BrEA
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Cytotoxicity against rat H9c2 cells after 72 hrs by Hoechst 33342 staining based fluorescence microscopy
Cytotoxicity against rat H9c2 cells after 72 hrs by Hoechst 33342 staining based fluorescence microscopy
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[PMID: 32551008] |
| H9c2 | EC50 |
6.4 μM
Compound: 3; BrEA
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Antitrypanosomal activity against Trypanosoma cruzi Y amastigotes infected in rat H9C2 cells after 72 hrs by Hoechst 33342 staining based fluorescence microscopy
Antitrypanosomal activity against Trypanosoma cruzi Y amastigotes infected in rat H9C2 cells after 72 hrs by Hoechst 33342 staining based fluorescence microscopy
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[PMID: 32551008] |
Chemical Information
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CAS No. 28507-02-0
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Molecular Weight 369.34
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Formula C19H29BrO2
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SMILES
C[C@@]12[C@]3([H])[C@](CC[C@@]1([H])C[C@H](CC2)O)([H])[C@@]4([H])[C@](CC3)(C([C@@H](C4)Br)=O)C
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Synonyms
16α-Bromoepiandrosterone
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Hernández-Pando R, et al. 16alpha-Bromoepiandrosterone restores T helper cell type 1 activity and accelerates chemotherapy-induced bacterial clearance in a model of progressive pulmonary tuberculosis. J Infect Dis. 2005 Jan 15;191(2):299-306. [Content Brief]
[2]. Nicoletti F, et al. 16alpha-Bromoepiandrosterone (HE2000) limits non-productive inflammation and stimulates immunity in lungs. Clin Exp Immunol. 2009 Dec;158(3):308-16. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
α-Epibromide Related Classifications
HY-106166 Related Classifications
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