αvβ1 integrin-IN-1 TFA
Based on 7 publication(s) in Google Scholar
αvβ1 integrin-IN-1 TFA (Compound C8) is a potent and selective αvβ1 integrin inhibitor with an IC50 of 0.63 nM. Antifibrotic effects.
For research use only. We do not sell to patients.
- Purity: 98.28%
- Formula: C28H35F3N6O8S
- Molecular Weight:672.67
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Bioactive Compound Library
HY-L001
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High-Throughput Bioactive Compound Library
HY-L205
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Immunology/Inflammation Compound Library
HY-L007
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Cytoskeleton Compound Library
HY-L060
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Targeted Diversity Library
HY-L099
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Heterocyclic Compound Library
HY-L138
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Membrane Protein-targeted Compound Library
HY-L149
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Highly Selective Inhibitors Library
HY-L158
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Extracellular Vesicles (EVs) Compound Library
HY-L168
Publications Citing Use of MedChemExpress (MCE) αvβ1 integrin-IN-1 TFA
More- Cancer Cell. 2023 Apr 10;41(4):757-775.e10. [Abstract]
- Nat Nanotechnol. 2026 Jun;21(6):880-891. [Abstract]
- ACS Nano. 2023 Dec 12;17(23):23679-23691. [Abstract]
- Cancer Lett. 2024 Nov 1:604:217199. [Abstract]
- Acta Biomater. 2021 May:126:183-198. [Abstract]
- Biochem Biophys Res Commun. 2026 Mar 19:805:153391. [Abstract]
- bioRxiv. 2024 Sep 21:2024.09.17.613509. [Abstract]
Biological Activity
IC50: 0.63 nM (αvβ1 integrin)[1]
Chemical Information
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Appearance Solid
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Molecular Weight 672.67
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Formula C28H35F3N6O8S
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Color White to off-white
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SMILES
O=C(O)[C@H](CC1=CC=C(NC(CCCCNC(N)=N)=O)C=C1)NC([C@H]2N(S(=O)(C3=CC=CC=C3)=O)CCC2)=O.OC(C(F)(F)F)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (7)
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Journal Impact Factor
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Most Recent
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Cancer Cell
Neutrophil extracellular traps formed during chemotherapy confer treatment resistance via TGF-β activation. [Abstract]2023 Apr 10;41(4):757-775.e10. PMID: 37037615 -
Nat Nanotechnol
2026 Jun;21(6):880-891. PMID: 42286217 -
ACS Nano
Controllably Self-Assembled Antibacterial Nanofibrils Based on Insect Cuticle Protein for Infectious Wound Healing. [Abstract]2023 Dec 12;17(23):23679-23691. PMID: 37983051 -
Cancer Lett
Identification of SPP1+ macrophages in promoting cancer stemness via vitronectin and CCL15 signals crosstalk in liver cancer. [Abstract]2024 Nov 1:604:217199. PMID: 39216547 -
Acta Biomater
Laminin alpha 4 promotes bone regeneration by facilitating cell adhesion and vascularization. [Abstract]2021 May:126:183-198. PMID: 33711525 -
Biochem Biophys Res Commun
RIPK3 exhibits a U-shaped dose-response in AKI-to-CKD progression: Optimal therapeutic window and the TGF-β1-HMGB1 feedback loop. [Abstract]2026 Mar 19:805:153391. PMID: 41637990 -
bioRxiv
Tenascin-C in the early lung cancer tumor microenvironment promotes progression through integrin αvβ1 and FAK. [Abstract]2024 Sep 21:2024.09.17.613509. PMID: 39345541
Solvent & Solubility
DMSO : 250 mg/mL (371.65 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 5 mg/mL (7.43 mM; ultrasonic and warming and heat to 60°C)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.08 mg/mL (3.09 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.08 mg/mL (3.09 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (276 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 1.4866 mL | 7.4331 mL | 14.8661 mL | 37.1653 mL |
| 5 mM | 0.2973 mL | 1.4866 mL | 2.9732 mL | 7.4331 mL | |
| DMSO | 10 mM | 0.1487 mL | 0.7433 mL | 1.4866 mL | 3.7165 mL |
| 15 mM | 0.0991 mL | 0.4955 mL | 0.9911 mL | 2.4777 mL | |
| 20 mM | 0.0743 mL | 0.3717 mL | 0.7433 mL | 1.8583 mL | |
| 25 mM | 0.0595 mL | 0.2973 mL | 0.5946 mL | 1.4866 mL | |
| 30 mM | 0.0496 mL | 0.2478 mL | 0.4955 mL | 1.2388 mL | |
| 40 mM | 0.0372 mL | 0.1858 mL | 0.3717 mL | 0.9291 mL | |
| 50 mM | 0.0297 mL | 0.1487 mL | 0.2973 mL | 0.7433 mL | |
| 60 mM | 0.0248 mL | 0.1239 mL | 0.2478 mL | 0.6194 mL | |
| 80 mM | 0.0186 mL | 0.0929 mL | 0.1858 mL | 0.4646 mL | |
| 100 mM | 0.0149 mL | 0.0743 mL | 0.1487 mL | 0.3717 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
αvβ1 integrin-IN-1 TFA Related Classifications
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