1. Apoptosis
  2. Apoptosis
  3. β-Elemene

β-Elemene (Synonyms: (-)-β-Elemene; Levo-β-elemene)

Cat. No.: HY-107324 Purity: 96.35%
Handling Instructions

β-Elemene ((-)-β-Elemene; Levo-β-elemene) is isolated from natural plant Curcuma wenyujin with an antitumor activity. β-Elemene can induce cell apoptosis.

For research use only. We do not sell to patients.

β-Elemene Chemical Structure

β-Elemene Chemical Structure

CAS No. : 515-13-9

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10 mM * 1 mL in DMSO USD 112 In-stock
Estimated Time of Arrival: December 31
5 mg USD 100 In-stock
Estimated Time of Arrival: December 31
10 mg USD 170 In-stock
Estimated Time of Arrival: December 31
50 mg USD 500 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

β-Elemene ((-)-β-Elemene; Levo-β-elemene) is isolated from natural plant Curcuma wenyujin with an antitumor activity. β-Elemene can induce cell apoptosis.

In Vitro

β-Elemene (0-200 µg/ml; 24 hours) shows IC50 values of 72.8 µg/ml; 47.4 µg/ml; 61.5 µg/ml; 3.661 µg/ml; 68 µg/ml; 72.12 µg/ml; 37.894 µg/ml and 37.703 µg/ml for SV-HUC-1, T24, 5637, TCCSUP, J82,UMUC-3,RT4, and SW780 cells, respectively[1].
β-Elemene (0-75 µg/ml; 24 hours) decreases cell number from 50 µg/ml and is notably decreased at 75 µg/ml,  induces dose-dependent G1-phase arrest in T24cells and significantly reduces the percentage of cells in the S-phase [1].
β-Elemene (50 µg/ml; 12 hours) downregulates the expression levels of p-STAT3 and the cell cycle-related proteins cyclin D1, CDK4 and CDK6, and upregulates p21 and p27expression in T24 cells [1].
β-Elemene (50 µg/ml; 24 hours) enhances cisplatin-induced apoptosis by activating the ROS-AMPK signaling pathway[1].

Cell Viability Assay[2]

Cell Line: T24, 5637, TCCSUP, J82, UM-UC-3, RT4 and SW780 cells
Concentration: 0, 6.25, 12.5, 25, 50, 100, 150 and 200 µg/ml
Incubation Time: 24 hours
Result: Inhibited the proliferation of RT4, SW780, J82, UMUC-3, TCCSUP, 5637 and T24 human bladder cancer cells and SV-HUC-1 human urothelial cells. 

Cell Cycle Analysis[2]

Cell Line: T24 and 5637 cells
Concentration: 0, 25, 50 and 75 µg/ml
Incubation Time: 24 hours
Result: Induced the percentage of cells in the S-phase as a dose-dependent manner.

Western Blot Analysis[2]

Cell Line: T24 cells
Concentration: 50 µg/ml
Incubation Time: 24 hours
Result: Downregulated p-STAT3 and cell cycle-related proteins.
Molecular Weight

204.35

Formula

C₁₅H₂₄

CAS No.

515-13-9

SMILES

CC([[email protected]]1[[email protected]@](C)(CC[[email protected]@H](C(C)=C)C1)C=C)=C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Pure form -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
References
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Keywords:

β-Elemene(-)-β-ElemeneLevo-β-elemeneApoptosisInhibitorinhibitorinhibit

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