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Cat. No.: HY-P10386

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155H1

155H1 (Compound 11) is a stapled peptide, that covalently binds hMcl1 (172-323) with IC₅₀ of 18 nM.

For research use only. We do not sell to patients.

Formula: C₇₉H₁₂₀FN₁₉O₂₃S
Molecular Weight:1754.98

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

155H1 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

155H1 (Compound 11) is a stapled peptide, that covalently binds hMcl1 (172-323) with IC₅₀ of 18 nM^[1].

All Bcl-2 Family Isoforms :

Chemical Information

Molecular Weight 1754.98
Formula C₇₉H₁₂₀FN₁₉O₂₃S
Sequence

Ac-{Dap(2MeO,5FSB)}-Ile-Ala-Glu-Gln-Leu-Arg-{(S)-2-(4-pentenyl)Ala}-Ile-Gly-Asp-{(S)-2-(4-pentenyl)Ala}-Phe-CONH2 (2MeO,5FSB=2-methoxy, 5-sulfonyl fluoride)
Sequence Shortening

Ac-{Dap(2MeO,5FSB)}-IAEQLR-{(S)-2-(4-pentenyl)Ala}-IGD-{(S)-2-(4-pentenyl)Ala}-F-CONH2 (2MeO,5FSB=2-methoxy, 5-sulfonyl fluoride)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (259 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Alboreggia G, et al., Histidine-Covalent Stapled Alpha-Helical Peptides Targeting hMcl-1. J Med Chem. 2024 May 23;67(10):8172-8185. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Biological Activity
- Description
Chemical Information
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References

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155H1

All Bcl-2 Family Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

155H1 Related Classifications

HY-P10386 Related Classifications