1. Metabolic Enzyme/Protease
    Protein Tyrosine Kinase/RTK
  2. Endogenous Metabolite
    FGFR

2,5-Dihydroxybenzoic acid 

Cat. No.: HY-W001179 Purity: 99.97%
Handling Instructions

2,5-Dihydroxybenzoic acid is a derivative of benzoic and a powerful inhibitor of fibroblast growth factors.

For research use only. We do not sell to patients.

2,5-Dihydroxybenzoic acid Chemical Structure

2,5-Dihydroxybenzoic acid Chemical Structure

CAS No. : 490-79-9

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
100 mg USD 50 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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View All FGFR Isoform Specific Products:

  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

2,5-Dihydroxybenzoic acid is a derivative of benzoic and a powerful inhibitor of fibroblast growth factors.

IC50 & Target[2]

Fibroblast growth factor

 

Human Endogenous Metabolite

 

In Vitro

2,5-Dihydroxybenzoic acid (Gentisic acid) is a derivative of benzoic and a minor product of the metabolic break down of aspirin[1]. 2,5-Dihydroxybenzoic acid is also a component of many traditional liquors and herbal remedies, is singled out as a powerful inhibitor of fibroblast growth factors. 2,5-Dihydroxybenzoic acid is used as a lead to identify additional compounds with better inhibitory characteristics generating a new chemical class of fibroblast growth factor inhibitors that includes the agent responsible for alkaptonuria. Through low and high resolution approaches, using representative members of the fibroblast growth factor family and their cell receptors, it is shown that this class of inhibitors may employ two different mechanisms to interfere with the assembly of the signaling complexes that trigger fibroblast growth factor-driven mitogenesis[2].

In Vivo

It is verified from in vivo disease models that this group of inhibitors (e.g., 2,5-Dihydroxybenzoic acid) may be of interest to treat cancer and angiogenesis-dependent diseases[2].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 6.4885 mL 32.4423 mL 64.8845 mL
5 mM 1.2977 mL 6.4885 mL 12.9769 mL
10 mM 0.6488 mL 3.2442 mL 6.4885 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

154.12

Formula

C₇H₆O₄

CAS No.

490-79-9

SMILES

Oc1ccc(c(c1)C(=O)O)O

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
2,5-Dihydroxybenzoic acid
Cat. No.:
HY-W001179
Quantity:

2,5-Dihydroxybenzoic acid

Cat. No.: HY-W001179