2-CEES
Based on 1 Customer Validation
2-CEES is a mustard gas analog forms only DNA monoadducts. 2-CEES induces centrosome amplification in human and mouse cells. 2-CEES induces centrosome amplification and chromosome instability.
For research use only. We do not sell to patients.
- Purity: 97.3%
- CAS No.: 693-07-2
- Formula: C4H9ClS
- Molecular Weight:124.63
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Storage:
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Chemical Information
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CAS No. 693-07-2
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Appearance Liquid
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Molecular Weight 124.63
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Formula C4H9ClS
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Color Colorless to light yellow
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SMILES
CCSCCCl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Solvent & Solubility
DMSO : ≥ 100 mg/mL (802.38 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 5 mg/mL (40.12 mM); Clear solution
This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 5 mg/mL (40.12 mM); Clear solution
This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (267 KB)
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SDS (958 KB)
- English - EN (958 KB)
- Français - FR (958 KB)
- Deutsch - DE (958 KB)
- Norwegian - NO (958 KB)
- Español - ES (958 KB)
- Swedish - SV (958 KB)
- Italian - IT (958 KB)
- Korean - KR (958 KB)
- Portuguese - PT (958 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 8.0238 mL | 40.1188 mL | 80.2375 mL | 200.5938 mL |
| 5 mM | 1.6048 mL | 8.0238 mL | 16.0475 mL | 40.1188 mL | |
| 10 mM | 0.8024 mL | 4.0119 mL | 8.0238 mL | 20.0594 mL | |
| 15 mM | 0.5349 mL | 2.6746 mL | 5.3492 mL | 13.3729 mL | |
| 20 mM | 0.4012 mL | 2.0059 mL | 4.0119 mL | 10.0297 mL | |
| 25 mM | 0.3210 mL | 1.6048 mL | 3.2095 mL | 8.0238 mL | |
| 30 mM | 0.2675 mL | 1.3373 mL | 2.6746 mL | 6.6865 mL | |
| 40 mM | 0.2006 mL | 1.0030 mL | 2.0059 mL | 5.0148 mL | |
| 50 mM | 0.1605 mL | 0.8024 mL | 1.6048 mL | 4.0119 mL | |
| 60 mM | 0.1337 mL | 0.6686 mL | 1.3373 mL | 3.3432 mL | |
| 80 mM | 0.1003 mL | 0.5015 mL | 1.0030 mL | 2.5074 mL | |
| 100 mM | 0.0802 mL | 0.4012 mL | 0.8024 mL | 2.0059 mL |
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