5-Bromomethylthalidomide

Cat. No.: HY-W454678 Purity: 95.74%: Data Sheet
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5-Bromomethylthalidomide is an E3 ligase activator which may be further derivatized by substitution at bromide.

For research use only. We do not sell to patients.

5-Bromomethylthalidomide Chemical Structure

CAS No. : 1312023-72-5

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
100 mg	In-stock	Estimated Time of Arrival: December 31
250 mg	In-stock	Estimated Time of Arrival: December 31
500 mg	In-stock	Estimated Time of Arrival: December 31
1 g	In-stock	Estimated Time of Arrival: December 31
5 g	Get quote
10 g	Get quote

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•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All Ligands for E3 Ligase Isoform Specific Products:

View All Isoforms

von Hippel-Lindau (VHL) MDM2 Cereblon IAP KLHDC2 Fbxo3 RNF4 DCAF11 DCAF1 UHRF1 TRIM21 NEURL1B

Biological Activity
Purity & Documentation
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Description

5-Bromomethylthalidomide is an E3 ligase activator which may be further derivatized by substitution at bromide.

Molecular Weight

351.15

Formula

C₁₄H₁₁BrN₂O₄

CAS No.

1312023-72-5

Appearance

Solid

SMILES

O=C1C2=CC=C(CBr)C=C2C(N1C3C(NC(CC3)=O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (284.78 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.8478 mL	14.2389 mL	28.4779 mL
5 mM	0.5696 mL	2.8478 mL	5.6956 mL
10 mM	0.2848 mL	1.4239 mL	2.8478 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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In Vivo Dissolution Calculator

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Working solution concentration: mg/mL

Purity & Documentation

Purity: 95.74%

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Data Sheet (242 KB) SDS (614 KB)

COA (248 KB) HNMR (128 KB) RP-HPLC (113 KB) LCMS (95 KB)

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.8478 mL	14.2389 mL	28.4779 mL	71.1946 mL
	5 mM	0.5696 mL	2.8478 mL	5.6956 mL	14.2389 mL
	10 mM	0.2848 mL	1.4239 mL	2.8478 mL	7.1195 mL
	15 mM	0.1899 mL	0.9493 mL	1.8985 mL	4.7463 mL
	20 mM	0.1424 mL	0.7119 mL	1.4239 mL	3.5597 mL
	25 mM	0.1139 mL	0.5696 mL	1.1391 mL	2.8478 mL
	30 mM	0.0949 mL	0.4746 mL	0.9493 mL	2.3732 mL
	40 mM	0.0712 mL	0.3560 mL	0.7119 mL	1.7799 mL
	50 mM	0.0570 mL	0.2848 mL	0.5696 mL	1.4239 mL
	60 mM	0.0475 mL	0.2373 mL	0.4746 mL	1.1866 mL
	80 mM	0.0356 mL	0.1780 mL	0.3560 mL	0.8899 mL
	100 mM	0.0285 mL	0.1424 mL	0.2848 mL	0.7119 mL