AN11251
Based on 1 Customer Validation
AN11251 is a potent and oral active anti-Wolbachia agent with potential for treatment of onchocerciasis and lymphatic filariasis, with EC50 values of 1.5 nM in LDW1 cell lines and 15 nM in C6/36 cell lines.
For research use only. We do not sell to patients.
- Purity: 99.45%
- CAS No.: 2130750-59-1
- Formula: C29H38BFO7
- Molecular Weight:528.42
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Storage:
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All Parasite Isoforms
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Biological Activity
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:CB.17 SCID mice inoculated with 50 L3-stage B. malayi larvae[1].
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Dosage:25 mg/kg.
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Administration:Orally, BID for 7 or 14 days.
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Result:Reduced the Wolbachia load in the B. malayi larvae by 75.4% and 98.8% in the 7- and 14-day treatment groups, respectively.
Chemical Information
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CAS No. 2130750-59-1
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Appearance Solid
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Molecular Weight 528.42
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Formula C29H38BFO7
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Color White to off-white
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SMILES
O=C(O[C@H]1[C@@]([C@H](C)CC2)(C)[C@@](C(CC3)=O)([H])[C@]32[C@@H](C)[C@H](O)[C@](C)(C=C)C1)COC4=CC=C5COB(O)C5=C4F
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
DMSO : ≥ 100 mg/mL (189.24 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (288 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.8924 mL | 9.4622 mL | 18.9243 mL | 47.3109 mL |
| 5 mM | 0.3785 mL | 1.8924 mL | 3.7849 mL | 9.4622 mL | |
| 10 mM | 0.1892 mL | 0.9462 mL | 1.8924 mL | 4.7311 mL | |
| 15 mM | 0.1262 mL | 0.6308 mL | 1.2616 mL | 3.1541 mL | |
| 20 mM | 0.0946 mL | 0.4731 mL | 0.9462 mL | 2.3655 mL | |
| 25 mM | 0.0757 mL | 0.3785 mL | 0.7570 mL | 1.8924 mL | |
| 30 mM | 0.0631 mL | 0.3154 mL | 0.6308 mL | 1.5770 mL | |
| 40 mM | 0.0473 mL | 0.2366 mL | 0.4731 mL | 1.1828 mL | |
| 50 mM | 0.0378 mL | 0.1892 mL | 0.3785 mL | 0.9462 mL | |
| 60 mM | 0.0315 mL | 0.1577 mL | 0.3154 mL | 0.7885 mL | |
| 80 mM | 0.0237 mL | 0.1183 mL | 0.2366 mL | 0.5914 mL | |
| 100 mM | 0.0189 mL | 0.0946 mL | 0.1892 mL | 0.4731 mL |
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