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  3. AN11251

AN11251 

Cat. No.: HY-111543
Handling Instructions

AN11251 is a potent and oral active anti-Wolbachia agent with potential for treatment of onchocerciasis and lymphatic filariasis, with EC50 values of 1.5 nM in LDW1 cell lines and 15 nM in C6/36 cell lines.

For research use only. We do not sell to patients.

AN11251 Chemical Structure

AN11251 Chemical Structure

CAS No. : 2130750-59-1

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Description

AN11251 is a potent and oral active anti-Wolbachia agent with potential for treatment of onchocerciasis and lymphatic filariasis, with EC50 values of 1.5 nM in LDW1 cell lines and 15 nM in C6/36 cell lines[1].

In Vivo

AN11251 (25 mg/kg, PO, BID for 7 or 14 days) reduces the Wolbachia load in the B. malayi larvae by 75.4% and 98.8% in the 7- and 14-day treatment groups, respectively[1].

Animal Model: CB.17 SCID mice inoculated with 50 L3-stage B. malayi larvae[1].
Dosage: 25 mg/kg.
Administration: Orally, BID for 7 or 14 days.
Result: Reduced the Wolbachia load in the B. malayi larvae by 75.4% and 98.8% in the 7- and 14-day treatment groups, respectively.
Molecular Weight

528.42

Formula

C₂₉H₃₈BFO₇

CAS No.

2130750-59-1

SMILES
Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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