AN11251

Cat. No.: HY-111543 Purity: 99.45%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

AN11251 is a potent and oral active anti-Wolbachia agent with potential for treatment of onchocerciasis and lymphatic filariasis, with EC₅₀ values of 1.5 nM in LDW1 cell lines and 15 nM in C6/36 cell lines.

For research use only. We do not sell to patients.

AN11251 Chemical Structure

CAS No. : 2130750-59-1

Size		Stock
1 mg		Check price and availability
5 mg		Check price and availability
10 mg		Check price and availability

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All Parasite Isoform Specific Products:

View All Isoforms

Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vivo

AN11251 (25 mg/kg, PO, BID for 7 or 14 days) reduces the Wolbachia load in the B. malayi larvae by 75.4% and 98.8% in the 7- and 14-day treatment groups, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	CB.17 SCID mice inoculated with 50 L3-stage B. malayi larvae^[1].
Dosage:	25 mg/kg.
Administration:	Orally, BID for 7 or 14 days.
Result:	Reduced the Wolbachia load in the B. malayi larvae by 75.4% and 98.8% in the 7- and 14-day treatment groups, respectively.

Molecular Weight

528.42

Formula

C₂₉H₃₈BFO₇

CAS No.

2130750-59-1

Appearance

Solid

Color

White to off-white

SMILES

O=C(O[C@H]1[C@@]([C@H](C)CC2)(C)[C@@](C(CC3)=O)([H])[C@]32[C@@H](C)[C@H](O)[C@](C)(C=C)C1)COC4=CC=C5COB(O)C5=C4F

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL (189.24 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.8924 mL	9.4622 mL	18.9243 mL
5 mM	0.3785 mL	1.8924 mL	3.7849 mL
10 mM	0.1892 mL	0.9462 mL	1.8924 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.45%

Select Batch:

Data Sheet (288 KB) SDS (252 KB)

COA (257 KB) HNMR (268 KB) RP-HPLC (258 KB) NP-HPLC (202 KB) LCMS (110 KB)

Handling Instructions (2659 KB)

References

[1]. Jacobs RT, et al. Boron-Pleuromutilins as Anti- Wolbachia Agents with Potential for Treatment of Onchocerciasis and Lymphatic Filariasis. J Med Chem. 2019 Mar 14;62(5):2521-2540. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.8924 mL	9.4622 mL	18.9243 mL	47.3109 mL
	5 mM	0.3785 mL	1.8924 mL	3.7849 mL	9.4622 mL
	10 mM	0.1892 mL	0.9462 mL	1.8924 mL	4.7311 mL
	15 mM	0.1262 mL	0.6308 mL	1.2616 mL	3.1541 mL
	20 mM	0.0946 mL	0.4731 mL	0.9462 mL	2.3655 mL
	25 mM	0.0757 mL	0.3785 mL	0.7570 mL	1.8924 mL
	30 mM	0.0631 mL	0.3154 mL	0.6308 mL	1.5770 mL
	40 mM	0.0473 mL	0.2366 mL	0.4731 mL	1.1828 mL
	50 mM	0.0378 mL	0.1892 mL	0.3785 mL	0.9462 mL
	60 mM	0.0315 mL	0.1577 mL	0.3154 mL	0.7885 mL
	80 mM	0.0237 mL	0.1183 mL	0.2366 mL	0.5914 mL
	100 mM	0.0189 mL	0.0946 mL	0.1892 mL	0.4731 mL

AN11251 Related Classifications

Infection

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AN112512130750-59-1AN 11251AN-11251ParasiteInhibitorinhibitorinhibit

Your Recently Viewed Products:

Product Name

Requested Quantity *

Applicant Name *

Salutation

Email Address *

Phone Number *

Department

Organization Name *

City

State

Country or Region *

Remarks

Product Name

Lot #

Applicant Name *

Email Address *

Phone Number

Department *

Organization Name *

Country or Region *

Remarks

Name
Email *

	Sorry, but the email address you supplied was invalid.

AN11251

AN11251 Related Antibodies

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All Parasite Isoform Specific Products:

Biological Activity

Purity & Documentation

References

Customer Review

Molarity Calculator

Dilution Calculator