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Butylphthalide (Synonyms: 3-n-Butylphthalide; 3-Butylphthalide)

Cat. No.: HY-B0647 Purity: 99.84%
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Butylphthalide(3-n-Butylphthalide) is an anti-cerebral-ischemia drug; first isolated from the seeds of celery, showed efficacy in animal models of stroke.

For research use only. We do not sell to patients.

Butylphthalide Chemical Structure

Butylphthalide Chemical Structure

CAS No. : 6066-49-5

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Solution
10 mM * 1 mL in DMSO USD 106 In-stock
Estimated Time of Arrival: December 31
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10 mM * 1 mL
ready for reconstitution
USD 106 In-stock
Estimated Time of Arrival: December 31
Liquid
10 mg USD 96 In-stock
Estimated Time of Arrival: December 31
50 mg USD 216 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 2 publication(s) in Google Scholar

Top Publications Citing Use of Products

Publications Citing Use of MCE Butylphthalide

    Butylphthalide purchased from MCE. Usage Cited in: Front Aging Neurosci. 2019 Feb 28;11:44.

    The protein level of TNF-α, IL-1β, iNOS and COX2 is analyzed by Western Blot with or without the treatment of NBP and LPS.
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    Description

    Butylphthalide(3-n-Butylphthalide) is an anti-cerebral-ischemia drug; first isolated from the seeds of celery, showed efficacy in animal models of stroke. IC50 value: Target: 3-n-butylphthalide alleviates oxidative stress caused by chronic cerebral ischemia, improves cholinergic function, and inhibits amyloid beta accumulation, thereby improving cerebral neuronal injury and cognitive deficits [2]. Intragastric NBP administration to 4-month-old SAMP8 mice for 2 months significantly improved spatial learning and memory ability. Moreover, the loss of choline acetyltransferase (ChAT)-positive neurons in the medial septal nucleus and the vertical limb of the diagonal band in SAMP8 mice was slowed down, as was the decline in the protein and mRNA expression of ChAT in the hippocampus, cerebral cortex, and forebrain [4].

    Clinical Trial
    Molecular Weight

    190.24

    Formula

    C₁₂H₁₄O₂

    CAS No.
    SMILES

    O=C1OC(CCCC)C2=C1C=CC=C2

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Pure form -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 56 mg/mL (294.37 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 5.2565 mL 26.2826 mL 52.5652 mL
    5 mM 1.0513 mL 5.2565 mL 10.5130 mL
    10 mM 0.5257 mL 2.6283 mL 5.2565 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.5 mg/mL (13.14 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 2.5 mg/mL (13.14 mM); Clear solution

    • 3.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 2.5 mg/mL (13.14 mM); Clear solution

    *All of the co-solvents are provided by MCE.
    References

    Purity: 99.98%

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    Keywords:

    Butylphthalide3-n-Butylphthalide 3-ButylphthalideOthersInhibitorinhibitorinhibit

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    Product Name:
    Butylphthalide
    Cat. No.:
    HY-B0647
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