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Clozic (Synonyms: ICI 55897; Clobuzarit)

Cat. No.: HY-100142
Handling Instructions

Clozic is a potential anti-arthritic agent.

For research use only. We do not sell to patients.

Clozic Chemical Structure

Clozic Chemical Structure

CAS No. : 22494-47-9

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Description

Clozic is a potential anti-arthritic agent.

In Vitro

Clozic is a potential anti-arthritic agent. Concentrations of Clozic greater than 50 μM cause a dose-dependent decrease in the amount of matrix protein synthesized by RHMC cell cultures. Inhibition of RHMC cell culture growth by Clozic occurs in a dose-dependent manner. The anti-proliferative effect of Clozic on RHMC cell growth is reversible. Lactate dehydrogenase (LDH) levels in media taken from RHMC cell cultures exposed to 500 μM Clozic for 3 days do not significantly differ from LDH levels in control cell culture media[1].

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Cell Assay
[1]

Approximately 3×104 to 5×104 cells/mL medium are seeded into 24-well plates and incubated at 37°C in a humidified atmosphere of 95% air/5% CO2. Medium is replaced with fresh medium containing 20% foetal calf serum and methanol or Clozic under investigation. Cell numbers are determined in replicate wells on various days during culture growth[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

304.77

Formula

C₁₇H₁₇ClO₃

CAS No.

22494-47-9

SMILES

CC(C)(OCC1=CC=C(C2=CC=C(Cl)C=C2)C=C1)C(O)=O

Shipping

Room temperature in continental US; may vary elsewhere

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Clozic
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Clozic

Cat. No.: HY-100142