1. GPCR/G Protein
    Immunology/Inflammation
  2. Histamine Receptor
  3. H4 Receptor antagonist 1

H4 Receptor antagonist 1 

Cat. No.: HY-114025 Purity: 99.70%
Handling Instructions

H4 Receptor antagonist 1 is a potent and selective histamine H4 receptor inverse agonist, with an IC50 of 19 nM.

For research use only. We do not sell to patients.

H4 Receptor antagonist 1 Chemical Structure

H4 Receptor antagonist 1 Chemical Structure

CAS No. : 848217-00-5

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 99 In-stock
Estimated Time of Arrival: December 31
5 mg USD 90 In-stock
Estimated Time of Arrival: December 31
10 mg USD 140 In-stock
Estimated Time of Arrival: December 31
50 mg USD 490 In-stock
Estimated Time of Arrival: December 31
100 mg USD 850 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Top Publications Citing Use of Products
  • Biological Activity

  • Technical Information

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Description

H4 Receptor antagonist 1 is a potent and selective histamine H4 receptor inverse agonist, with an IC50 of 19 nM.

IC50 & Target[1]

H4 receptor

19 nM (IC50)

In Vitro

H4 Receptor antagonist 1 is a potent and selective histamine H4 receptor inverse agonist, with an IC50 of 19 nM[1].

In Vivo

H4 Receptor antagonist 1 indicates that metabolic stability in rat microsomes is very low with only 1% parent compound remaining after 10 min incubation[1].

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 10 mg/mL (31.57 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1567 mL 15.7833 mL 31.5667 mL
5 mM 0.6313 mL 3.1567 mL 6.3133 mL
10 mM 0.3157 mL 1.5783 mL 3.1567 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 1 mg/mL (3.16 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 1 mg/mL (3.16 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 1 mg/mL (3.16 mM); Clear solution

References
Molecular Weight

316.79

Formula

C₁₆H₁₇ClN₄O

CAS No.

848217-00-5

SMILES

CN1CCN(C2=C(OC3=CC=C(Cl)C=C34)C4=NC(C)=N2)CC1

Shipping

Room temperature in continental US; may vary elsewhere

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
H4 Receptor antagonist 1
Cat. No.:
HY-114025
Quantity:

H4 Receptor antagonist 1

Cat. No.: HY-114025