1. Cell Cycle/DNA Damage
  2. PPAR
  3. KD-3010


Cat. No.: HY-111068
Handling Instructions

KD-3010 is a potent, orally active, and selective PPARδ agonist.

For research use only. We do not sell to patients.

KD-3010 Chemical Structure

KD-3010 Chemical Structure

CAS No. : 934760-92-6

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KD-3010 is a potent, orally active, and selective PPARδ agonist.

IC50 & Target[1]



In Vivo

To determine whether PPARδ agonists are beneficial in experimental liver fibrosis, mice are treated orally with a PPARδ agonist, KD-3010, or with the well-validated PPARδ agonist GW501516. KD-3010, but not GW501516, shows hepatoprotective and antifibrotic effects in liver fibrosis induced by carbon tetrachloride (CCl4) or bile duct ligation (BDL). Liver injury is induced by repeated injections of CCl4, and mice are treated daily with vehicle, the widely used PPARδ agonist GW501516, or the PPARδ agonist KD-3010 by oral gavage. Control oil-injected mice do not show any liver damage. Liver injury consisting of hepatocyte death and inflammation is seen in the vehicle- or GW501516-treated group injected with CCl4 on H&E-stained liver sections but is markedly reduced in the KD3010-treated group[1].

Molecular Weight







O=C([[email protected]]1CC2=C(C(S(=O)(N3[[email protected]](C)CN(C4=CC=C(OC(F)(F)F)C=C4)C[[email protected]@H]3C)=O)=CC=C2)C1)O.OS(=O)(C5=CC=C(C)C=C5)=O


Room temperature in continental US; may vary elsewhere.


Please store the product under the recommended conditions in the Certificate of Analysis.

Animal Administration

Male 11-wk-old C57/B6 mice are treated with CCl4 (2 μL/g body weight; 1:4 dilution with corn oil) or with corn oil as control (2 μL/g body weight) by i.p. injection every third day. Injections are repeated for a total of 12 times. Mice are injected i.p. 12 times with oil as control (n=4 in each group) or with CCl4 and are administered vehicle (n=14), GW501516 (2 mg/kg; n=12), or KD3010 (10 mg/kg; n=11) daily by oral gavage[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

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