1. JAK/STAT Signaling
    Protein Tyrosine Kinase/RTK
  2. EGFR

PF-06459988 

Cat. No.: HY-19985 Purity: 98.72% ee.: 96.93%
Handling Instructions

PF-06459988 is an irreversible inhibitor of T790M-Containing EGFR Mutants.

For research use only. We do not sell to patients.

PF-06459988 Chemical Structure

PF-06459988 Chemical Structure

CAS No. : 1428774-45-1

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 88 In-stock
Estimated Time of Arrival: December 31
5 mg USD 80 In-stock
Estimated Time of Arrival: December 31
10 mg USD 140 In-stock
Estimated Time of Arrival: December 31
25 mg USD 290 In-stock
Estimated Time of Arrival: December 31
50 mg USD 520 In-stock
Estimated Time of Arrival: December 31
100 mg USD 920 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

PF-06459988 is an irreversible inhibitor of T790M-Containing EGFR Mutants.

IC50 & Target

IC50: 45 nM (H1975 EGFR), 3.3 μM (EGFR)

Clinical Trial
Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3155 mL 11.5773 mL 23.1546 mL
5 mM 0.4631 mL 2.3155 mL 4.6309 mL
10 mM 0.2315 mL 1.1577 mL 2.3155 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

431.88

Formula

C₁₉H₂₂ClN₇O₃

CAS No.

1428774-45-1

SMILES

C=CC(N1C[[email protected]](COC2=C3C(NC=C3Cl)=NC(NC4=CN(C)N=C4)=N2)[[email protected]@H](OC)C1)=O

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Inquiry Information

Product Name:
PF-06459988
Cat. No.:
HY-19985
Quantity:

PF-06459988

Cat. No.: HY-19985