Infection

UCB7362 is an orally active and potent antimalarial plasmepsin X (PMX) inhibitor, with an IC₅₀ of 7 nM. UCB7362 inhibits parasite growth.

Antileishmanial agent-33 (4e), a hybrid compound of grandisin and machilin G, shows moderate activity on promastigotes (IC₅₀ of 38.1 μM). Antileishmanial agent-33 (4e) shows potential as an antileishmanial agent for the research of cutaneous leishmaniasis (CL).

A 33903 is a respiratory syncytial virus (RSV) replication inhibitor. A 33903 can be used for the research of RSV-infection.

VCC234718 is a molecule with mycobacterial growth inhibitory activity, specifically targeting Mycobacterium tuberculosis (Mtb). The primary molecular target of VCC234718 is inosine monophosphate dehydrogenase (GuaB2), and it inhibits the growth of Mtb by affecting the function of this enzyme. VCC234718 inhibits GuaB2 with a K value of 100 nM and exhibits non-competitive inhibition with IMP and NAD+. VCC234718 exerts its inhibitory effect by directly interacting with IMP and binding at the NAD+ site.

Psoralenoside is a benzofuran glycoside from Psoralea corylifolia. Psoralenoside exhibits high binding affinities against histaminergic H1, calmodulin, and voltage-gated L-type calcium channels (E-value≥-6.5 Kcal/mol). Psoralenoside shows estrogen-like activity, osteoblastic proliferation accelerating activity, antitumor effects and antibacterial activity.

SDH-IN-44 is a succinate dehydrogenase (SDH) inhibitor with an IC₅₀ of 12.5 μg/mL against Alternaria solani. SDH-IN-44 exhibits antifungal activity and inhibits fungal mycelial growth. SDH-IN-44 is applicable to research related to fungal infections.

5-Carboxy-2′-deoxyuridine (Standard) is the analytical standard of 5-Carboxy-2′-deoxyuridine. This product is intended for research and analytical applications. 5-Carboxy-2′-deoxyuridine is a metabolite of Trifluridine. 5-Carboxy-2′-deoxyuridine is a methyl oxidation product of Thymidine that can be formed by menadione-mediated photosensitization of Thymidine.

Pacidamycin 7 has inhibitory effect on Pseudomonas aeruginosa. Pacidamycin 7 also has effect on a few strains of bacteria such as suppurative staphylococcus and Escherichia coli. Serum can reduce its antibacterial activity, pH also affects its antibacterial activity.

Cefmenoxime sodium is a new semisynthetic cephalosporin antibiotic. Cefmenoxime sodium has antibacterial activity against a wide variety of gram-positive and gram-negative bacteria.

Andropin is a male-specific antibacterial peptide that can be found in Drosophila melanogaster.

Kirrothricin has antibacterial action, but no activity to subtilis, E.coli and fungi.

Antibacterial agent 313 (Compound 20) is a broad-spectrum antibacterial agent. Antibacterial agent 313 can be used for research of bacterial infection.

Cyclic GMP sodium (Standard) is the analytical standard of Cyclic GMP sodium (HY-113469A). This product is intended for research and analytical applications. Cyclic GMP (cGMP) sodium, an important second messenger, is a major intracellular mediator of extracellular signals such as nitric oxide (NO) and natriuretic peptides (NPs). Effects of Cyclic GMP sodium occur through three main groups of cellular targets: cGMP-dependent protein kinases (PKGs), cGMP-gated cation channels, and PDEs. Cyclic GMP can inhibit both platelet adhesion and aggregation. cGAMP (Cyclic-GMP-AMP) (HY-12512), a conjugate of Cyclic GMP and AMP, can induce IRF3 phosphorylation and nuclear translocation, enhancing antiviral immune responses.

TNK-6123 is a potent Emivirine (HY-15353) analogue with improved activity against drug-resistant HIV mutants. TNK-6123 improves activity against Lys103Asn mutant RT.

Carbonic anhydrase-IN-36 (Compound 5p) is a MtCA 3 inhibitor with a K_i of 0.07 µM against MtCA 3. Carbonic anhydrase-IN-36 inhibits the β-class enzyme MtCA 3. Carbonic anhydrase-IN-36 demonstrates potent antimycobacterial activity, with an MIC of 8 µg/mL against Mtb. Carbonic anhydrase-IN-36 retains activity against Rifampicin (HY-B0272)-resistant M. tuberculosis.

Isoeugenol (Standard) is the analytical standard of Isoeugenol. This product is intended for research and analytical applications. Isoeugenol is an essential oil constituent of nutmeg, clove, and cinnamon. Isoeugenol inhibits growth of Escherichia coli and Listeria innocua with MICs of 0.6 mg/mL and 1 mg/mL, respectively.

SET-12 is an antiparasitic agent with high activity and selectivity against the Leishmania amazonensis. SET-12 exhibits excellent activity against the pre-flagellated form of the Leishmania amazonensis, with an IC₅₀ of 10.89 μM and a selectivity index (SI) of up to 12.1. SET-12 is also effective against the non-flagellated form within cells, with an IC₅₀ of 3.81 μM and a further increased selectivity index (SI) to 34.5. SET-12 causes signs of parasite cell apoptosis, including mitochondrial damage and accumulation of ROS.

3′-Deoxy CTP trisodium is the sodium salt form of 3′-Deoxy CTP (HY-171587). 3′-Deoxy CTP trisodium is a nucleotide analogue and a mandatory chain terminator. 3′-Deoxy CTP trisodium can cause chain termination by lacking the 3′-hydroxyl group, inhibiting the RNA synthesis activity of HCV nonstructural protein (NS5B) polymerase and blocking viral replication. 3′-Deoxy CTP trisodium can be used to study the chain termination mechanism of HCV polymerase and the development of antiviral drugs.

Artemitin (Standard) is the analytical standard of Artemitin. This product is intended for research and analytical applications. Artemitin is a flavonol found in Laggera pterodonta (DC.) Benth., with antioxidative, anti-inflammatory, and antiviral activity.

Tuberactinomycin A is a basic cyclic peptide antibiotic and a group I intron RNA splicing inhibitor, with an IC₅₀ of 10 μM against the G-binding site of bacteriophage T4 group I intron RNA. Tuberactinomycin A exerts antibacterial effects by acting on the initiation and elongation steps of bacterial bacteria ribosomes to inhibit prokaryotic protein synthesis. Tuberactinomycin A competes with guanosine cofactors for binding to the G-binding site of group I intron RNA, forms electrostatic interactions with the RNA backbone, and inhibits the self-splicing of bacteriophage T4 td and sunY group I introns, and its inhibitory activity depends on Mg²⁺ concentration. Tuberactinomycin A can be used in studies related to bacterial infections.