Infection

Raja 42-d₁₀ is the deuterium labeled Raja 42 (HY-W749146). Raja 42 is a gamma lactam antibiotic. Raja 42 is effective against a variety of different bacterias, including Gram-positive and Gram-negative bacteria, such as C. difficile strains.

MBL-IN-2 ((2R, 2R')-5αC) is an inhibitor of Metallo-β-lactamase (MBL) that can inhibit New Delhi Metallo-β-lactamase-1 (NDM-1) with an IC₅₀ of 0.3 μM. MBL-IN-2 ((2R, 2R')-5αC) can be used for the study of resistance to β-lactam antibiotics.

DL-Histidine-¹⁵N is a ¹⁵N-labeled DL-Histidinen (HY-W010209). DL-Histidine is a histidine derivative.

Antifungal agent 41 (compound B01) is an antifungal agent. Antifungal agent 41 shows inhibitory effect on Candida albicans in virto and vivo. Antifungal agent 41 can be used for the research of invasive fungal infections.

AK-Toxin II is a phytotoxic metabolite that can be isolated from culture broth of alternaria alternata Japanese pear pathotype. AK-Toxin II induces characteristic veinal necrosis and rapid K⁺ loss on susceptible pear leaves.

Chitin, from crab carapace is a long-chain polymer of N-acetylglucosamine with β-(1-4) linkages. Chitin, from crab carapace is found in the exoskeleton of crabs. Chitin, from crab carapace inhibits the activation of NF-κB p65, alters the translocation of NF-κB p65 to the nucleus, and interacts with the cell wall of Candida species. Chitin, from crab carapace exerts antifungal and anti-inflammatory effects. Chitin, from crab carapace can be used in the research of gastric ulcer and candidiasis.

AL-470 is a potent antiviral agent with EC₅₀ values of 0.27, 0.63, and 0.35 µM against HIV-1, HIV-2, and EV-A71, respectively.

InhA-IN-6 (compound 8) is InhA inhibitor with the IC₅₀ of 90 nM.

Fidaxomicin-d₆ (OPT-80-d₆) is the deuterium labeled Fidaxomicin (HY-17580). Fidaxomicin (OPT-80), a macrocyclic antibiotic, is an orally active and potent RNA polymerase inhibitor. Fidaxomicin has a narrow spectrum of antibacterial activity and a good anti-Clostridium difficile activity (MIC₉₀=0.12 μg/mL). Fidaxomicin can be used for Clostridium difficile infection (CDI) research.

3,6-Dichlorocatechol is a substrate of the broad-spectrum chlorocatechol 1,2-dioxygenase of pseudomonas chlororaphis RW71.

Betavulgaroside I (Compound 1) is a triterpene saponin found in sugar beet (Beta vulgaris) and beetroot. Betavulgaroside I can be used for research on antifungal activity.

Sparfloxacin-d5 is deuterium labeled Sparfloxacin (HY-B0308). Sparfloxacin is a fluoroquinolone antibiotic, shows broad and potent antibacterial activity.

rel-Bornyl cinnamate is an anti-schistosomal agent. rel-Bornyl cinnamate induces round, dark morphological changes, followed by degeneration in Schistosoma mansoni schistosomula. rel-Bornyl cinnamate can be used for the research of schistosomiasis.

1-Hydroxy-3-oxodecane-1-sulfonate sodium is a small-molecule acylacetaldehyde that can be used for the preparation of anti-inflammatory and bactericidal preparations.

Antibacterial agent 117, triazole derivative, is an antibacterial agent. Antibacterial agent 117 has against R. prowazekii MetAP1 (RpMetAP1) activity with an IC₅₀ value of 15 μM. Antibacterial agent 117 also inhibits rickettsial growth and can be used for the research of infection.

XSJ2-46, 5'-amino NI analog, is an antiviral agent. XSJ2-46 has anti-Zika virus activity. XSJ2-46 exhibits reasonable inhibition of RNA-dependent RNA polymerases (RdRp) with an IC₅₀ value of 8.78 μM.

G247 is a specific MsbA inhibitor. G247 acts as a transmembrane domains (TMDs) wedge, symmetrically increasing nucleotide-binding domains (NBDs) separation and preventing conformational transition of MsbA. G247 suppresses ATPase activity by increasing inter-NBD distance.

Lettowienolide, a geranylbenzoquinonoid, exhibits mild in vitro activity against the Plasmodium falciparum malaria parasite (IC₅₀~20 μg/mL).

Lysolipin I is a lipophilic antibiotic from Streptomyces violaceoniger. Lysolipin I is active against Gram-positive and Gramnegative bacteria.

Arborcandin E is a 1,3-β-glucan synthase inhibitor that serves as an antifungal antibiotic. Arborcandin E exhibits IC₅₀ values of 0.1 μg/mL and 0.012 μg/mL against Candida albicans and Aspergillus fumigatus, respectively. Additionally, Arborcandin E has an MIC of 0.5-2 μg/mL against the genus Candida.