Infection

Julocrotine is a naturally derived, orally active glutarimide alkaloid. Julocrotine alleviates rotenone-induced climbing impairment in Drosophila melanogaster and elevation of malondialdehyde levels in brain tissues, and restores the elevated mRNA levels of superoxide dismutase and catalase to normal. Julocrotine inhibits the growth of Leishmania amazonensis, induces its ultrastructural changes and reduces the number of amastigotes. Julocrotine can be used in research related to Parkinson's disease and cutaneous leishmaniasis.

(E)-Antiviral agent 67 (compound PC6) is a pyrazolone-based antiviral agent with certain inhibitory activity against RNA-dependent RNA polymerase.

Sodium methylparaben (Standard) is the analytical standard of Sodium methylparaben. This product is intended for research and analytical applications. Sodium methylparaben (Sodium methyl 4-hydroxybenzoate) is an antifungal agent.

Prumycin dihydrochloride is an antifungal antibiotic with activity against cucumber powdery mildew. Prumycin dihydrochloride significantly inhibited the disease, whereas other metabolites such as bacillomycin D and surfactin did not. Prumycin dihydrochloride did not induce the expression of plant defense genes, indicating that its effects were not through plant defense responses. Observation of cucumber cotyledons treated with prumycin showed that it could inhibit spore germination of P. fusca.

Plicacetin is a crystalline antibiotic isolated from the fermentation broth of Streptomyces actinomycetes and is structurally similar to Amicetin (HY-120383) and Bamicetin..

Isosulfazecin (iSZ) is a novel β-lactam antibiotic produced by Pseudomonas acidophilus sp., synthesized in a nutrient solution supplemented with glycerol and sodium thiosulfate under aerobic conditions in parallel with bacterial growth. It is purified by chromatography and crystallization from aqueous methanol. Physicochemical analysis determined its molecular formula to be C12H20N4O9S, showing a structure with a β-lactam ring, methoxyl and sulfonate groups. Acid hydrolysis yields L-alanine and D-glutamic acid. iSZ is a diastereomer of sulfadiazine and exhibits moderate activity against both gram-positive and gram-negative bacteria, but potent activity against bacteria resistant to β-lactam antibiotics.

Lauryl sulfate (Dodecyl hydrogen sulphate) is an anionic chaotropic surfactant. Lauryl sulfate dissolves viral envelopes, denatures viral proteins, inhibits viral infectivity and HIV-1 syncytium formation. Lauryl sulfate potently inhibits the infectivity of HSV-1 strain F (ED₅₀ = 17.9 μM) and HSV-2 strain 333 (ED₅₀ = 32.7 μM). Lauryl sulfate induces environmental toxicity, disrupting environmental balance and physiological processes of organisms. As a contaminant, Lauryl sulfate is toxic to aquatic and terrestrial organisms. Lauryl sulfate can be used in studies related to sexually transmitted infections.

Aminoacyl tRNA synthetase-IN-4 (Compound 1l) is an inhibitor of Aminoacyl tRNA synthetase, with an IC₅₀ of 0.026 μM for C.albicans prolyl-tRNA synthetase. Aminoacyl tRNA synthetase-IN-4 can be used for antifungal research.

Liposomal Amphotericin B (Amphotericin B liposome) is a liposomal formulation of Amphotericin B (HY-B0221) that can cross the blood-brain barrier. Liposomal Amphotericin B binds to fungal cell walls and releases Amphotericin B to bind Ergosterol (HY-N0181), inducing pore formation, ion leakage, and fungal cell death. Liposomal Amphotericin B exhibits fungicidal activity against a broad spectrum of fungal pathogens, also shows activity against Leishmania, and the liposomal formulation has lower acute and chronic toxicity as well as a lower risk of fungal resistance.

Antibacterial agent 260 (Compound 4r) exhibits board-spectrum antibacterial activity, inhibits P. aeruginosa and S. aureus with MIC of 0.0076 μM. Antibacterial agent 260 acts as a herbicidal agent, that inhibits the root- and stem-growth of Raphanus sativus L. (radish seed).

Baquiloprim (Standard) is the analytical standard of Baquiloprim (HY-19581). This product is intended for research and analytical applications. Baquiloprim is an orally active Antibiotic and selective inhibitor of Bacterial Dihydrofolate reductase (DHFR), with an IC₅₀ of 19 nM against E. coli and an IC₅₀ of 190 μM against rat liver dihydrofolate reductase. Baquiloprim is a bacteriostatic broad-spectrum antibacterial agent that acts against Gram-negative and Gram-positive bacteria. Baquiloprim inhibits glucuronidation in cultured hepatocytes. Baquiloprim can be used in research related to Pasteurella haemolytica infection, bacterial infection, Escherichia coli diarrhea, bacterial infection in pigs, and pneumonic pasteurellosis.

Foscarnet (sodium) (Standard) is the analytical standard of Foscarnet (sodium). This product is intended for research and analytical applications. Foscarnet sodium (Trisodium phosphonoformate) is a viral DNA polymerase activity inhibitor, leading to reversible suppression of viral replication. Foscarnet sodium is an antiherpesvirus agent used in cytomegalovirus retinitis.

Napsamycin C is an antibiotic. Napsamycin C has antibacterial activity against Pseudomonas aeruginosa and other pseudomonas, but has weak antibacterial activity against other Gram-positive and negative bacteria.

SPK-843 is an antifungal agent. SPK-843 shows inhibitory activity against A. fumigatus MF-13, A. flavus TIMM 0057, and A. niger TIMM 2814 with MICs of 0.5 μg/mL, 0.25 μg/mL, and 0.0625 μg/mL, respectively. SPK-843 exhibits dose-dependent efficacy in murine models of pulmonary aspergillosis. SPK-843 can be used for the research of related fungal infections.

GSK 124576A (compound 8) is a Mycobacterium tuberculosis cytochrome bc1 complex inhibitor and member of the 2-(quinolin-4-yloxy)acetamide class. GSK 124576A can be used for the research of tuberculosis.

IspE kinase-IN-1 (compound 4) is a potent IspE kinase inhibitor with IC₅₀ values of 6.2, 5.2 µM for EclspE, KplspE, respectively.

Platenomycin A0 is a macrolide antibiotic with anti-Gram-positive bacteria activities.

Kerriamycin A has anti-Gram-positive bacterial effect and can inhibits Ai's ascites cancer.

(Z)-8-Dodecen-1-ol (cis-8-Dodecen-1-ol) is an insect pheromone agonist and attractant active substance. (Z)-8-Dodecen-1-ol serves as the main component of the sex pheromone gland in female Cryptophlebia horii, exhibits stable attractant activity towards male moths, and induces significant electroantennogram signals. (Z)-8-Dodecen-1-ol can be used in studies related to male moth trapping and pest control.

ACP1-01 is a bacterial ClpP activator with EC₅₀s of 3.4 and 2.6  μM for Neisseria meningitides ClpP (NmClpP) and Escherichia coli ClpP (EcClpP). ACP1-01 noncovalently binds to ClpP C sites and activates the protease. ACP1-01 has antibacterial activity. ACP1-01 can be used for bacterial infections research.