Infection

Nitrosulfathiazole (Nisulfazole; p-Nitrosulfathiazole) is a sulfonamide antibacterial agent and also a key chemical intermediate for the hematotoxicity of Chloramphenicol (HY-B0239). Nitrosulfathiazole induces DNA helix instability, strand breakage and aplastic anemia. Nitrosulfathiazole can be used in research related to bacterial infections and aplastic anemia.

Scytalol D is a natural compound found in the strain of Scytalidium sp. 36-93.

D-Ribonolactone (Standard) is the analytical standard of D-Ribonolactone. This product is intended for research and analytical applications. D-Ribonolactone is sugar lactone and an inhibitor of β-galactosidase of Escherichia coli with a Ki of 26 mM.

LQB-118 is an orally active compound derived from sandalwood. LQB-118 can inhibit the migration of glioblastoma cells and induce cell death. LQB-118 can suppress the migration and invasion of prostate cancer cells by regulating the AKT/GSK3β pathway and the expression of the MMP-9/reck genes. LQB-118 can also inhibit yeast polysaccharide-induced inflammation both in vivo and in vitro. Additionally, LQB-118 selectively induces ROS-triggered and mitochondrial-dependent apoptosis in Leishmania amazonensis. LQB-118 can be used in studies related to inflammation, infections, and cancer diseases.

Lincosamine is a lincosamide antibiotic with activity that inhibits bacterial growth. Lincosamine is primarily produced by Streptomyces lincolnensis. Lincosamine has shown efficacy in combating certain bacterial infections, especially against Klebsiella pneumoniae. Lincosamine ranked among 14 other antimicrobial compounds in its activity against Klebsiella pneumoniae in a test.

NMT-IN-9 is an arylpyrrolidone-based NMT inhibitor with an IC₅₀ of 93.20 nM and a K_D of 5.57 × 10^-9 M against NMT. NMT-IN-9 exhibits broad-spectrum antifungal activity against Candida albicans, Candida glabrata, Candida tropicalis, Cryptococcus neoformans and Aspergillus fumigatus, with an MIC of 2-16 μg/mL, and retains activity against fluconazole-resistant Candida isolates, with an MIC of 8-16 μg/mL. NMT-IN-9 induces intracellular ROS accumulation, mitochondrial membrane depolarization, DNA damage, apoptosis and necrotic cell death in fungal cells, and disrupts fungal cell integrity. NMT-IN-9 can be used for studies on NMT-targeted antifungal mechanisms and fluconazole-resistant Candida infections.

Cefditoren Pivoxil-d₃ (Cefditoren pivoxyl-d₃) is deuterium labeled Cefditoren Pivoxil. Cefditoren Pivoxil (ME 1207) is a broad-spectrum, third-generation, oral cephalosporin antibacterial with enhanced stability against many common β lactamases. Cefditoren Pivoxil has activity against Gram-negative organisms and Gram-positive organisms. Cefditoren Pivoxil can be used in the research of infection diseases such as acute exacerbations of chronic bronchitis, community-acquired pneumonia (CAP), streptococcal pharyngitis/tonsillitis, or uncomplicated skin and skin structure infections.

DDAN-MT is an enzymatic activated near-infrared fluorescent probe. DDAN-MT can be used for rapid, highly selective, and real-time monitoring of endogenous MtMET-AP1 activity in M. tuberculosis.

N-3-Hydroxydecanoyl-L-homoserine lactone is a type of N-acyl-L-homoserine lactone (AHL), which is a class of signaling molecules in bacterial quorum sensing systems, and it has a weak activating effect on AbaR.

Kerriamycin A has anti-Gram-positive bacterial effect and can inhibits Ai's ascites cancer.

PB(OH)3 is an anti-HIV-1 agent that can be used in antiviral research.

Lactonamycin had strong activity against Gram-positive bacteria including Staphylococcus, Streptococcus, Enterococcus, MRSA (MIC of 0.39-0.78 μg/mL) and VRE (MIC of 0.39-0.78 μg/mL). Lactonamycin also has inhibitory effect on L-1210, P388, S180, FS-3, Ehrlich, B16-BL5 and other tumor cell lines (IC₅₀s of 0.06-3.3 μg/mL).

Bayer 9017 is an insecticide with plasma cholinesterase inhibitory activity and toxicity. Bayer 9017 inhibits plasma cholinesterase activity in chicks. Bayer 9017 prevents the colonization of Lucilia sericata larvae, kills first-instar Lucilia sericata larvae, and provides myiasis protection for sheep, with seasonal variations in its protective performance. Bayer 9017 is applicable to research related to myiasis.

GRL-07524 (Compound 4e) is a potent inhibitor of HIV-1 protease (K_i = 0.22 nM). GRL-07524 contains oxaspirocyclic carbamates as the P2 ligands. GRL-07524 exhibits good antiviral activity with an EC₅₀ = 210 nM. GRL-07524 binds to the HIV-1 PR active site in one of the four symmetry independent molecules along with key catalytic residues.

M&B 4935 is an orally active Amoebicide. M&B 4935 reduces the levels of *Entamoeba histolytica* parasites in rodents. M&B 4935 can be used for the research of amoebiasis.

3-epi-Deoxynegamycin shows antibacterial activity against most Gram-positive bacteria, and its anti-Gram-negative bacteria activity is a little weak.

Steffimycin B is an anthracycline bacterial metabolite originally isolated from Streptomyces. It binds to DNA, preferentially intercalating at sites containing cytosine and guanine.2 Steffimycin B is cytotoxic to MCF-7, KB, NCI-H187, and Vero cells (IC₅₀s=3.5, 6.75, 3.28, and 10.5 μM, respectively). It is active against M. tuberculosis (MIC=5.2 nM), B. cereus (MIC=1.56 μg/mL), and P. falciparum (IC₅₀=2.19 μM).

HDM-IN-1 (Compound A4) is an inhibitor for fungal histone demethylase (HDM), that inhibits the H3K27me3 in Cryptococcus neoformans and in Candida auris with IC₅₀s of 134 and 12 nM. HDM-IN-1 exhibits inhibitory efficacy against C. neoformans and C. auris with MIC₈₀ of 0.5-2 μg/mL, through inhibition of the biofilm and capsule formation. HDM-IN-1 exhibits antifungal activity in ICR mouse model.

(S)-ZK824859 hydrochloride is a uPA inhibitor and anticoagulant. (S)-ZK824859 hydrochloride can be used for the research of severe acute respiratory syndrome caused by coronavirus and complications thereof .

Penicillin G procaine (hydrate) (Standard) is the analytical standard of Penicillin G procaine (hydrate). This product is intended for research and analytical applications. Penicillin G Procaine hydrate (PGP hydrate), a β-lactam antibiotic, is a crystalline complex produced by chemically combining penicillin G with procaine.