Infection

Spiroamantadine (DU-34569 maleate) is a compound related to Amantadine (HY-B0402) with anti-influenza virus activity.

MPD2 is a SARS-CoV-2 M^Pro PROTAC degrader with an IC₅₀ <1000 nM against SARS-CoV-2 M^Pro. MPD2 engages CRBN to mediate ubiquitination and proteasomal degradation of SARS-CoV-2 M^Pro, reducing SARS-CoV-2 M^Pro protein levels in infected cells. MPD2 inhibits viral replication of various SARS-CoV-2 strains and acts against Nirmatrelvir (HY-138687)-resistant SARS-CoV-2 viruses. MPD2 can be used for the research of COVID-19 and for fighting against drug-resistant viral variants.

Metoprolol-d₆-1 tartrate is the deuterium labeled Metoprolol tartrate (HY-17503B). Metoprolol tartrate is an orally active, selective β1-adrenoceptor antagonist. Metoprolol tartrate shows anti-inflammation, antitumor and anti-angiogenic properties.

Alternariol (Standard) is the analytical standard of Alternariol. This product is intended for research and analytical applications. Alternariol is an orally ingested mycotoxin produced by Alternaria, capable of inhibiting the activity of topoisomerase I and II (topoisomerase I, topoisomerase II). Alternariol has weak estrogenic (Estrogen Receptor/ERR) and androgen/antiandrogen (Androgen Receptor) effects. Alternariol can induce apoptosis, trigger cell cycle arrest, suppress innate immune responses, and exhibit anti-tumor activity. Alternariol has genotoxic, mutagenic, and endocrine-disrupting effects.

Antibacterial agent 141 (Compound B14) has antibacterial activity against four plant pathogens Xoo, Xac, Psa and Cmm, with an EC₅₀ value of 1.28 μM. Antibacterial agent 141 can inhibit the formation of cell membrane and change cell permeability.

PDF-IN-1 (compound 2) is a potential Peptide deformylase (PDF) inhibitor. PDF-IN-1 can be used for the development of new broad-spectrum antibiotics.

6''-O-(3'''-Hydroxy-3'''-methylglutaryl) vitexin is an orally active flavonoid glycoside and insecticide that can be isolated from the twigs of Eleusine coracana. 6''-O-(3'''-Hydroxy-3'''-methylglutaryl) vitexin exhibits distinct antifeedant activity against Nilaparvata lugens (brown planthopper) nymphs and effectively inhibits their feeding behavior. 6''-O-(3'''-Hydroxy-3'''-methylglutaryl) vitexin can serve as a plant-derived natural defense substance for regulating pest behavior and investigating potential control mechanisms of agricultural pests.

IN-RNA-IN-2 (compound 1a) is an inhibitor (IC₅₀=70 nM) of the interaction between HIV-1 integrase and the viral RNA genome. IN-RNA-IN-2 exerts its anti-HIV activity by inhibiting the viral replication process.

RdRP-IN-7 is a RNA-dependent RNA polymerase (RdRp) inhibitor that shows the inhibition of SARS-CoV-2 infection with an IC₅₀ of 8.2 μM, an IC₉₀ of 14.1 μM and an CC₉₀ of 79.1 μM. RdRP-IN-7 can be used for antiviral research.

Lactucin (Standard) is the analytical standard of Lactucin. This product is intended for research and analytical applications. Lactucin is an anti-inflammatory agent. Lactucin induces cancer cell apoptosis. Lactucin also shows analgesic, anticancer and antimalarial activities[4].

Myeloperoxidase, Human Neutrophil is a peroxidase. Myeloperoxidase, Human Neutrophil is a potent antibacterial agent by catalyzing the H₂O₂-dependent oxidation of chloride anion to generate hypochlorous acid. Myeloperoxidase, Human Neutrophil catalyzes the degradation of N-retinyl-idene-N-retinylethanolamine, a toxic form of retinal lipofuscin. Myeloperoxidase, Human Neutrophil also triggers lysosomal stress and cell death. Myeloperoxidase, Human Neutrophil can be used for the researches of inflammation and infection.

Enfumafungin (Standard) is the analytical standard of Enfumafungin. This product is intended for research and analytical applications. Enfumafungin, a triterpene glycoside, is isolated from extracts derived from fungus Hormonema carpetanum. Enfumafungin is an antifungal compound that is acting on the fungal cell wall, as the (1,3)-beta-D-glucan synthase inhibitor. Enfumafungin is specific for yeasts and fungi (excluding Cryptococcus) and does not inhibit the growth of Bacillus subtilis[1][2].

Chitin synthase-IN-16 is a competitive Chitin synthase 2 inhibitor with an IC₅₀ of 20.89 μM against CaChs2. Chitin synthase-IN-16 synergistically enhances the activity of Fluconazole (HY-B0101) against Fluconazole-tolerant Candida albicans. Chitin synthase-IN-16 can be used for research on invasive fungal infections.

Parvodicin C2 is a glycopeptide antibiotic that can be isolated from parvosata. Parvodicin C2 has antibacterial activity.

Cap-dependent endonuclease-IN-2 is a potent inhibitor of cap-dependent endonuclease (CEN). Not only can Cap-dependent endonuclease-IN-2 inhibit influenza virus well, but also has lower cytotoxicity, better in vivo agent kinetic properties and in vivo pharmacodynamic properties. Cap-dependent endonuclease-IN-2 has strong inhibitory effect on RNA polymerase activity of A virus (extracted from patent WO2019052565A1, compound 28).

Cyclopetide 2 (Compound 2) is an antimicrobial peptide with moderate activity against B. subtilis, with a MIC of 50 μg/mL.

Ianthelliformisamine C ditrifluoroacetate is an antibiotic enhancer with activity against resistant Gram-negative bacteria. Ianthelliformisamine C ditrifluoroacetate has been shown to improve the efficacy of doxycycline against Pseudomonas aeruginosa. Ianthelliformisamine C ditrifluoroacetate was prepared using peptide coupling, resulting in high chemical yields of 27 to 91%. Ianthelliformisamine C ditrifluoroacetate exhibits its mechanism of action by inducing ATP efflux and causing membrane depolarization in bacterial cells.

VP1 ligand-1 (Scheme 1 A 1) is a VP1 ligand. VP1 ligand-1 acts as a ligand for target protein for PROTAC (Ligands for Target Protein for PROTAC) and is used for the development and design of PROTAC-based VP1 degraders, such as Jun15702 (HY-182924). VP1 ligand-1 is applicable to EV-D68 infection research.

Chlortetracycline-d₆ (hydrochloride) is the deuterium labeled Chlortetracycline hydrochloride. Chlortetracycline hydrochloride (7-Chlorotetracycline hydrochloride) is a specific and potent calcium ionophore antibiotic, inhibits binding of aminoacyl-tRNA to ribosomes.

Rehmaglupentasaccharide A is a pentasaccharide found in air-dried roots of Rehmannia glutinosa. Rehmaglupentasaccharide A promotes proliferation of Lactobacillus reuteri.