Infection

Nitrocefin (Standard) is the analytical standard of Nitrocefin. This product is intended for research and analytical applications. Nitrocefin is a chromogenic β-lactamase substrate that undergoes a distinctive color change from yellow to red as the amide bond in the β-lactam ring is hydrolyzed by β-lactamase. Nitrocefin is used in competitive inhibition studies in developmental work on β-lactamase-resistant antibiotics.

Rifabutin-vonoprazan conjugate 1 is an orally active acid-responsive bifunctional molecule. Rifabutin-vonoprazan conjugate 1 exhibits anti-Helicobacter pylori activity (MIC ≤ 0.125 μg/mL) and acid-suppressive effects (acid inhibition rate > 85% at a dose of 2 mg/kg). Rifabutin-vonoprazan conjugate 1 also demonstrates anti-ulcer activity. Rifabutin-vonoprazan conjugate 1 can be used in research related to Helicobacter pylori infection and gastric ulcer.

HIV-1 inhibitor-76 (compound 9t-2) is a non-nucleoside reverse transcriptase inhibitor of HIV-1. HIV-1 inhibitor-76 can be used in anti-HIV research.

Isomalathion is an isomer and impurity of Malathion (HY-B0943). Isomalathion inhibits Carboxyesterase and AChE, with an IC₅₀ value of 3.2 μM against bovine acetylcholinesterase. Isomalathion moderately reduces CYP1A2 transcript levels, increases CYP2B6 transcript levels, and induces dose-dependent DNA damage. Malathion is an organophosphorus insecticide.

Cetalkonium (chloride) (Standard) is the analytical standard of Cetalkonium (chloride). This product is intended for research and analytical applications. Cetalkonium chloride is an ammonium antiseptic agent used in many topical agents for infections of mouth, throat and eye. Cetalkonium chloride acts as anti-inflammatory amphiphilic agent. Cetalkonium chloride is a cationic surfactant, that improves the precorneal residence time and bioavailability of drugs. Cetalkonium chloride interacts with the negative charges on the bacterial cell membrane, disrupts the integrity of the cell membrane, causes leakage of cell contents and ultimately leading to bacterial death.

SDH-IN-46 is a succinate dehydrogenase (SDH) inhibitor with an IC₅₀ of 1.21 μM. SDH-IN-46 disrupts fungal respiration via mitochondrial respiratory chain enzyme targeting and exhibits broad-spectrum antifungal activity. SDH-IN-46 exhibits substantial protective effects against S. sclerotiorum on oilseed rape leaves, Rhizoctonia solani on rice leaves, and Valsa mali on apple fruits.

Influenza A virus-IN-17 (Compound 6a) is a potent influenza A inhibitor with EC₉₀s of 3.5 μM and 2.6 μM for H3N2 and H1N1, respectively. Influenza A virus-IN-17 inhibits U2-PB2 chimeric mRNA (EC₉₀ = 2.1 μM from cap snatching polymerase).

Streptothricin F is a bactericidal antibiotic. Streptothricin F interacts with the 30S subunit of 70S ribosome. Streptothricin F shows rapid, bactericidal activity against highly drug-resistant, carbapenem-resistant Enterobacterales (CRE) (MIC₅₀ and MIC₉₀: 2 and 4 μM, respectively) and Acinetobacter baumannii.

(E)-8-Dodecenyl ((E)-8-Dodecen-1-yl; trans-8-Dodecenyl) acetate is a sex pheromone targeting the olfactory receptors of male Gymnandrosoma aurantianum moths. acting as an agonist. (E)-8-Dodecenyl acetate is promising for research of agricultural pests.

SARS-CoV-2 nsp14-IN-11 (Compound 13) is a NSP14 exonuclease inhibitor (pIC₅₀ = 4.4). SARS-CoV-2 nsp14-IN-11 shows robust and complete NSP14 exonuclease inhibition. SARS-CoV-2 nsp14-IN-11 can be used in the research of SARS-CoV-2 infection.

Epigoitrin (Standard) is the analytical standard of Epigoitrin. This product is intended for research and analytical applications. Epigoitrin is a natural alkaloid that provides protection against influenza infection by reducing the host’s susceptibility to influenza virus under stress. Epigoitrin exerts antiviral activity against influenza A1 virus FM1 via inhibiting virus attachment and multiplication in vitro. Epigoitrin also has lipid-lowering effects.

Pipcroside C is found in P. crocatum Ruiz & Pav. Pipcroside C is a PDH inhibitor (IC₅₀: 80.25 µM). Pipcroside C has antibacterial activity and is used in the study of oral infections.

Phoslactomycin A has weak effect against Gram-positive bacteria, but has strong effect against fungi.

(+)-β-Pinene (d-β-Pinene) acts as an Antifungal and Antibacterial agent. (+)-β-Pinene inhibits Phospholipase. (+)-β-Pinene interferes with fungal cell wall function, reduces Candida biofilm adhesion, inhibits Candida albicans biofilm formation, and suppresses the growth of various Candida species. Combined with Ciprofloxacin (HY-B0356), (+)-β-Pinene exerts synergistic antibacterial activity against Methicillin (HY-121544)-resistant Staphylococcus aureus. (+)-β-Pinene can be used in research related to candidiasis and Staphylococcus aureus infections.

cis-ICeD-2 is the cis isomer of ICeD-2 (HY-151871). ICeD-2 is a cell death inducer that induces cell death in HIV-1-infected cells. ICeD-2-mediated killing of HIV-1-infected cells is dependent on HIV-1 protease activity. ICeD-2 effectively blocks the hydrolysis of Gly-Pro-AMC by the dipeptidyl peptidases DPP8 and DPP9. ICeD-2 demonstrates strong stability against DPP9 in PBMCs..

HC103A is an Antibacterial agent and a DosS/DosT histidine sensor kinase inhibitor, with an IC₅₀ of 0.5 μM against DosS and ~5 μM against DosT of *Mycobacterium tuberculosis*. HC103A inhibits the autophosphorylation of DosS/DosT. HC103A suppresses hypoxia-induced triacylglycerol synthesis and the viability of Mtb. HC103A can be used in the research of tuberculosis.

Demeclocycline hydrochloride (Standard) is the analytical standard of Demeclocycline hydrochloride (HY-17560). This product is intended for research and analytical applications. Demeclocycline hydrochloride is an orally active tetracycline antibiotic that inhibits the binding of aminoacyl tRNA by binding to the 30S ribosomal subunit, thereby affecting protein synthesis. Demeclocycline hydrochloride exhibits antibacterial activity against a broad spectrum of bacterial infections.

Antibacterial agent 254 (Compound 2) is a dispersion sensor (DspS) activator that disperses Pseudomonas aeruginosa biofilms. Antibacterial agent 254 can dislodge 7-day P. aeruginosa biofilms at 50 μM. Antibacterial agent 254 also enhances the effects of Ciprofloxacin (HY-B0356) against P. aeruginosa and increases the expression of matrix-degrading enzyme genes pelA, pslG and eddA.

NadD-IN-1 is a bacterial NadD inhibitor. NadD-IN-1 can be used for the research of bacterial infections.

Piperanine is an antifungal agent. Piperanine shows growth inhibition against the fungus Cladosporium claspoirioides. Piperanine can be isolated from the fruits of Piper retrofractum.