Inflammation/Immunology

Vimirogant hydrobromide (VTP-43742 hydrobromide) is a potent, selective, and orally active RORγt inhibitor with a K_i of 3.5 nM for binding to RORγt. VTP-43742 blocks Th17 cell differentiation and reduces IL-17A production by inhibiting RORγt-mediated transcriptional activity, thereby suppressing the RORγt/Th17/IL-17 inflammatory axis. VTP-43742 can be used for research on autoimmune diseases and inflammation-related diseases.

PF-06422913 is an orally active, potent and selective metabotropic glutamate receptor 5 (mGluR5) negative allosteric modulator.

Tesmilifene (fumarate) (Standard) is the analytical standard of Tesmilifene (fumarate). This product is intended for research and analytical applications. Tesmilifene fumarate (DPPE fumarate), an H1C receptor antagonist, potentiates a wide range of cytotoxics and even to offer some protection of normal cells.

Lactosyl fructoside (Lactosucrose) is a non-reducing trisaccharide composed of galactose, glucose, and fructose. Lactosyl fructoside is produced by enzymatic transfructosylation of sucrose with lactase. Lactosyl fructoside is not digested by human digestive tract enzymes and, upon entering the colon, is selectively fermented by beneficial bacteria such as Bifidobacteria, exhibiting prebiotic effects. Lactosyl fructoside serves as a low-calorie sweetener for diabetic and obese populations. Lactosyl fructoside improves the fermentation and refrigeration quality of yogurt, maintains the viable count and texture of starter lactic acid bacteria, and modulates the metabolite profile. Lactosyl fructoside is used in studies related to yogurt fermentation and intestinal diseases.

3-Methylhistamine (dihydrochloride) (Standard) is the analytical standard of 3-Methylhistamine (dihydrochloride). This product is intended for research and analytical applications. 3-Methylhistamine dihydrochloride is a degradation product of histamine. 3-Methylhistamine dihydrochloride, a methylated product of histamine, is associated with immune response and shows upregulation in the vaccinated mice.

Lansoprazole sulfone N-Oxide (Comound 3) is the overoxidized by-product found in the synthesis of the proton pump inhibitor Lansoprazole (HY-13662). Lansoprazole sulfone N-Oxide is promising for research of duodenal and gastric ulcers, reflux oesophagitis, and Zollinger–Ellison syndrome.

Digitoxigenin-3-O-β-D-quinovoside is an interleukin-2 (IL-2)/luciferase inhibitor with an IC₅₀ value of 52 nM. Digitoxigenin-3-O-β-D-quinovoside is a cardiac lactone isolated from Elaeodendron australe var. integrifolium.

Sativanone is a compound that can be isolated from Dalbergia tonkinensis. Sativanone is a potent α-glucosidase inhibitor, with an EC₅₀ of 0.357 mg/mL for rat α-glucosidase. Sativanone has antibacterial activity against Ralstonia solanacearum. Sativanone also has anti-senescent and antioxidant effects.

SX 3202 is an aldose reductase inhibitor. SX 3202 can be used for the research of diabetic complications.

Etalocib (Standard) is the analytical standard of Etalocib. This product is intended for research and analytical applications. Etalocib (LY293111), an orally active leukotriene B4 receptor antagonist, inhibits the binding of [3H]LTB4, with a Ki of 25 nM. Etalocib (LY293111) prevents LTB4-induced calcium mobilization with an lC50 of 20 nM. Etalocib (LY293111) induces apoptosis.

Antipyrine (Standard) is the analytical standard of Antipyrine. This product is intended for research and analytical applications. Antipyrine (Phenazone) is an antipyretic and analgesic. Antipyrine can be used as a probe agent for oxidative agent metabolism. Antipyrine has been widely used in assessment of hepatic oxidative capacity.

Fluxapyroxad (Standard) is the analytical standard of Fluxapyroxad. This product is intended for research and analytical applications. Fluxapyroxad is a synthetic broad-spectrum fungicide for the control of fungal diseases. It works by inhibiting succinate dehydrogenase in complex II of the mitochondrial respiratory chain, resulting in inhibition of spore germination, germ tubes and mycelia growth within the fungus target species.

D 22888 is an orally active PDE4 inhibitor, with human PDE4 IC₅₀ of 0.153 μM, and selectivity over PDE3 and PDE5. D 22888 elevates intracellular cAMP levels to modulate target cell functions. D 22888 acts as a relaxant of human bronchial ring inherent tone. D 22888 inhibits opsonized zymosan-induced superoxide anion generation by human eosinophils. D 22888 reduces bronchoalveolar lavage eosinophil numbers in allergen-challenged sensitized guinea pigs via single or chronic oral dosing. D 22888 can be used for the research of bronchial asthma.

3,4-Dimethoxyphenylacetic acid (Standard) is the analytical standard of 3,4-Dimethoxyphenylacetic acid (HY-Y0771). This product is intended for research and analytical applications. 3,4-Dimethoxyphenylacetic acid is a phenylacetic acid class urinary metabolite of 3,4-dimethoxyphenethylamine and also a building block in chemical synthesis. 3,4-Dimethoxyphenylacetic acid is produced by the gut microbiota during colonic fermentation of phenolic compounds from Achillea millefolium L. and Origanum majorana L. 3,4-Dimethoxyphenylacetic acid can be used in studies related to gut microbiota metabolism.

Ladyginoside A is a triterpenoid saponin found in the leaves of Polyscias fruticosa (L.) Harms. Ladyginoside A has inhibitory activities against α-amylase and α-glucosidase, and can regulate carbohydrate metabolism. Ladyginoside A also exhibits potential anti-inflammatory and mast cell stabilizing effects. Ladyginoside A can be used for the researches of inflammation and metabolic disease, such as diabetes.

Antileishmanial agent-28 (Compd 12) is an antileishmanial agent, with EC₅₀ values of 1.5 μM (L.donovani), 13 μM (L.amazonensis) and 18 μM (J774A.1), respectively.

Rofleponide 21-palmitate is a lipophilic Corticosteroid prodrug. Rofleponide 21-palmitate reduces subcutaneous edema, plasma haptoglobin levels, and plasma levels of IL-6, KC, IP-10, MCP-1. Rofleponide 21-palmitate increases and prolongs mRNA-encoded protein expression in lipid nanoparticle formulations.

Polyozellin is a prolyl endopeptidase inhibitor. Polyozellin has activities against inflammation, cancer, and oxidative stress-related disorders. .

STAT3-IN-39 (compound 10K) is an orally active STAT3 inhibitor that exhibits excellent inhibitory activity against STAT3 phosphorylation, with an IC₅₀ of 0.47 μM in NIH-3T3 cells. STAT3-IN-39 inhibits the TGF-β1-induced fibrotic response and blocks the epithelial-mesenchymal transition in A549. STAT3-IN-39 can be utilized in research related to idiopathic pulmonary fibrosis.

Wilforgine (Standard) is the analytical standard of Wilforgine. This product is intended for research and analytical applications. Wilforgine is a bioactive sesquiterpene alkaloid in Tripterygium wilfordii Hook. F. Wilforgine can induce microstructural and ultrastructural changes in the muscles of Mythimna separata larvae, and the sites of action are proposed to be calcium receptors or channels in the muscular system.