Neurological Disease

Alizapride-¹³C,d₃ (hydrochloride) is deuterium labeled Alizapride (hydrochloride). Alizapride hydrochloride is a dopamine receptor antagonist with prokinetic and antiemetic effects which can also be used in the treatment of nausea and vomiting, including postoperative nausea and vomiting.

(D-Ala)-Peptide T is an octapeptide derived from gp120. (D-Ala)-Peptide T releases chemokines and prevents HIV-1 GP120-induced neuronal death. (D-Ala)-Peptide T can be used in research on infectious and neurological diseases such as AIDS-related dementia.

Piezo1 agonist 2 (Compound PD2) is a blood-brain barrier-permeable Piezo1 agonist and Jedi2 (HY-131018) conjugate that utilizes LAT1. Piezo1 agonist 2 releases Jedi2 in mice. Piezo1 agonist 2 can be used for the research of neurodegenerative diseases.

Evariquinone is an anthraquinone compound isolated from the endophytic fungus Colletotrichum sp. JS-0367 of mulberry. Evariquinone possesses direct antioxidant activity. It inhibits excessive phosphorylation of the JNK, ERK1/2 and p38 MAPK signaling pathways by suppressing ROS and Ca²⁺, thereby reducing neuronal apoptosis. Evariquinone can be used to study glutamate excitotoxicity-related neurological disorders (such as Alzheimer's disease, Parkinson's disease, cerebral ischemia, etc.).

NO-711 (NNC-711) free acid is a novel potent and selective inhibitor of γ-aminobutyric acid uptake. NO-711 inhibits synaptosomal (IC₅₀ = 47 nM), neuronal (IC₅₀ = 1238 nM) and glial (IC₅₀ = 636 nM) GABA uptake in vitro.

Fenobucarb (Standard) is the analytical standard of Fenobucarb. This product is intended for research and analytical applications. Fenobucarb is a carbamate insecticide. Fenobucarb induces zebrafish developmental neurotoxicity through pathways involved in inflammation, oxidative stress, degeneration and apoptosis. Fenobucarb is a possible risk factor to cardiovascular and cerebrovascular systems in animals.

Buspirone-d8 dihydrochloride is the deuterium labeled Buspirone hydrochloride (HY-B1115). Buspirone hydrochloride is a 5-HT1A receptor agonist. Buspirone hydrochloride can be used for anxiety and depression research.

Ondansetron-¹³C,d₃ is the ¹³C- and deuterium labeled Ondansetron (HY-B0002B). Ondansetron (GR 38032; SN 307) is a highly selective 5-HT₃ receptor antagonist with an IC₅₀ value of 103 pM. Ondansetron exerts its antiemetic effect by antagonizing 5-HT receptors located in localized neurons in the peripheral and central nervous systems. Ondansetron can inhibit nausea and vomiting induced by chemotherapy and radiotherapy.

OX2R-IN-3 (Compound 53) is an orally active type 2 orexin receptor (OX2R) agonist (EC₅₀<100 nM.).

FKBP51-Hsp90-IN-1 (Compound D10) is a selective inhibitor of the FKBP51-Hsp90 protein-protein interaction, with an IC₅₀ value of 0.1 μM against FKBP51. FKBP51-Hsp90-IN-1 can be used in the research of stress-related diseases, Alzheimer's disease, and metabolic disorders.

4-Chloromethamphetamine hydrochloride is a new psychoactive substance belonging to the amphetamine class.

CHIR-98023 is a potent, selective and reversible inhibitor of GSK3, with IC₅₀s of 10 nM and 6.7 nM for GSK3α and GSK3β, respectively. CHIR-98023 can improve insulin action and glucose metabolism.

WWamide-3 is a neuropeptide, which can be isolated form Achatina fulica. WWamide-3 inhibits the rhythmic contraction of anterior byssus retractor muscle (ABRM).

Sodium carbonate anhydrous, meets analytical specification of Ph. Eur., BP, NF, FCC, E500 is a biochemical assay reagent suitable for buffer configuration.

D-Alanine (Standard) is the analytical standard of D-Alanine. This product is intended for research and analytical applications. D-Alanine is a weak GlyR (inhibitory glycine receptor) and PMBA agonist, with an EC50 of 9 mM for GlyR.

Sinomenine hydrochloride (Standard) is the analytical standard of Sinomenine hydrochloride. This product is intended for research and analytical applications. Sinomenine hydrochloride (Cucoline hydrochloride), an alkaloid extracted from Sinomenium acutum, is a blocker of the NF-κB activation. Sinomenine also is an activator of μ-opioid receptor.

(R)-Citalopram-d₄ (oxalate) is deuterium labeled (R)-Citalopram Oxalate. (R)-Citalopram oxalate, a R-(-) enantiomers of Citalopram (HY-121203), is a serotonin reuptake inhibitor. (R)-Citalopram oxalate is at least 20-fold weaker than S-citalopram (HY-14258) as inhibitor of the 5-HT transporter (SERT). (R)-Citalopram oxalate can be used for research of depression.

ORL1 antagonist 1 is an opioid receptor-like 1 (ORL1) antagonist with an IC₅₀ of 61 nM.

BChE-IN-16 (compound 87) is a highly potent BChE inhibitor with an IC₅₀ of 3.8 nM for hBChE. BChE-IN-16 has low cytotoxicity, potential CNS permeability, unique adaptability and can be used in Alzheimer's disease (AD) research.

(S)-Baclofen hydrochloride is a GABAB receptor agonist that crosses the blood-brain barrier and is orally active, with IC₅₀ values ​​of 1.77 μM for GABAB and 1564 μM for GABAA. (S)-Baclofen hydrochloride can be used in research on muscle disorders such as spasticity.