Neurological Disease

Aβ Fibrillization modulator 1 stabilizes Aβ monomers.

Crystamidine is an alkaloid can be isolated from the flower and seed extracts of Erythrina caffra Thunb., Fabaceae. Crystamidine can be studied in research on Alzheimer’s disease.

BACE1-IN-1 hydrochloride is an orally active, blood-brain barrier penetrant dual-target inhibitor of BACE1/2, with IC₅₀ values of 23 nM and 24 nM against human BACE1 and BACE2, respectively. BACE1-IN-1 hydrochloride reduces cerebral Aβ40 levels in mice. BACE1-IN-1 hydrochloride can be used in studies related to Alzheimer's disease and type 2 diabetes.

PROTAC CBP/P300 Degrader-2 (compound 2) is a PROTAC-based CBP/P300 degrader that can be used in the research of cancer, autoimmune, inflammatory, and neurodegenerative diseases.

Orphenadrine-d₃ (hydrochloride) is the deuterium labeled Orphenadrine hydrochloride. Orphenadrine hydrochloride is an orally active and non-competitive NMDA receptor antagonist (crosses the blood-brain barrier) with a K_i of 6.0 μM. Orphenadrine hydrochloride relieves stiffness, pain and discomfort due to muscle strains, sprains or other injuries. Orphenadrine hydrochloride is also used to relieve tremors associated with parkinson's disease. Orphenadrine citrate has good neuroprotective properties, can be used in studies of neurodegenerative diseases.

MAO-B-IN-4 (Compound 26) is an orally active and reversible MAO-B inhibitor with an IC₅₀ of 9 nM. MAO-B-IN-4 has good metabolic stability, safety profile and brain permeability. MAO-B-IN-4 shows antidepressant activity in rats and mice. MAO-B-IN-4 can be used in studies related to Alzheimer's disease.

(S)-CPW 399 is a subtype-selective full agonist of AMPA receptors, with a 20-fold higher selectivity for GluA1 and GluA2 subunits over GluA3 and GluA4 subunits. (S)-CPW 399 can significantly increase the spontaneous firing rate (FR) of LC noradrenergic neurons by activating AMPA receptors containing GluA1 subunits. (S)-CPW 399 can be used for the study of neurological diseases.

Ipsapirone hydrochloride (TVX Q 7821) is an anxiolytic compound and a 5-HT_1A receptor partial agonist. Ipsapirone hydrochloride (TVX Q 7821) also exhibits 5-HT_1A receptor antagonistic effect, and only at high doses it can also produce an inhibitory effect on 5-HT₂ and the α₁-adrenergic function.

5,5-Diphenylbarbituric acid is an organic compound belonging to the derivatives of barbituric acid. 5,5-Diphenylbarbituric acid can be used for seizure study.

Calcium green-5N hexapotassium is a cell-impermeant Ca²⁺-sensitive fluorescent probe. Calcium green-5N hexapotassium shows enhancement in fluorescence intensity on binding Ca²⁺, and can monitor free Ca²⁺ in neurons.

Mimosa pudica root extract is a root extract of the sensitive plant (Mimosa pudica) that has diuretic activity.

Nefopam-d₃ is a deuterium labeled Nefopam (Fenazoxine). Nefopam is a centrally-acting but non-opioid analgesic drug, and Nefopam targets β-catenin protein level in mesenchymal cells.

Ethybenztropine hydrobromide (Ponalid hydrobromide) is an anticholinergic drug with antiparkinsonian activity. Ethybenztropine hydrobromide may also act as a dopamine reuptake inhibitor. Ethybenztropine hydrobromide is commonly used to suppress Parkinson's disease.

DAA-1097 is an orally active and selective agonist for the peripheral benzodiazepine receptor (PBR). DAA-1097 has anxiolytic effects.

3-O-Methyltolcapone-d₄ (Ro 40-7591 d₄) is a deuterium labeled 3-O-Methyltolcapone (HY-174062). 3-O-Methyltolcapone (Ro 40-7591) is a metabolite of Tolcapone (HY-17406). Tolcapone (Ro 40-7592) is a selective, potent and orally active COMT inhibitor with an IC₅₀of 773 nM. Tolcapone can inhibits α-syn and Aβ₄₂ oligomerization and fibrillogenesis. Tolcapone can cause oxidative stress and induce cancer cells apoptosis and ROS production. Tolcapone can be used for the researches of cancer and neurological disease, such as Parkinson disease and neuroblastoma.

Casein kinase 1δ-IN-26 (compound 505) is a potent casein kinase 1δ inhibitor. Casein kinase 1δ-IN-26 can be used in the study of neurodegenerative diseases such as Alzheimer's disease.

LIMK-IN-3 (Compound 33) is a LIMK2 inhibitor (IC₅₀: 1.2 nM). LIMK-IN-3 can be used for glaucoma research.

NLRP3-IN-63 (Compound 7) is an inhibitor for NLRP3, that inhibits the NLRP3 activation with an EC₅₀ of 13 nM.

UCM765 is a selective MT2-type melatonin receptor ligand with hypnotic, analgesic and anxiolytic activities. The partial agonist effect of UCM765 has attracted attention in pharmacological studies. By structurally modifying UCM765, its water solubility and metabolic stability can be improved, thereby increasing its bioavailability. The biological activity of UCM765 has been verified in a rat model, supporting its potential for further pharmacological studies.

RH 3421, an insecticidal dihydropyrazole, acts as an inhibitor of sodium channel-specific sodium uptake, blocking the uptake stimulated by Veratridine (HY-N6691), Vatrachotoxin (HY-12549), crude scorpion.