Neurological Disease

DPP-IV-IN-2 (Standard) is the analytical standard of DPP-IV-IN-2 (HY-108319). This product is intended for research and analytical applications. DPP-IV-IN-2 is an inhibitor of both dipeptidyl peptidase IV (DPIV) and DP8/9 with IC₅₀s of 0.1 and 0.95 μM, respectively.

Galanthamine-d₃ (Galantamine-d₃) hydrochloride is deuterium-labeled Galanthamine (HY-76299).

PB-22 N-Pentanoic acid-3-carboxyindole metabolite is a metabolite of PB-22. PB-22 is a cannabinoid.

D-5-Hydroxytryptophan (D-5-HTP) is the D-isomer of 5-HTP and can be isolated from DL-5-hydroxytryptophan by continuous separation. Compared with intraperitoneal administration of L-5-Hydroxytryptophan, which can induce dose-dependent backward walking behavior in mice, D-5-Hydroxytryptophan has no significant effect on mouse behavior and is a negative control. D-5-Hydroxytryptophan is also a 5-HT ligand, capable of binding to the 5-HT site with affinity in the micromolar range.

Secoverine is a muscarinic cholinergic receptor (mAChR) antagonist and antispasmodic with blood-brain barrier permeability. Secoverine binds competitively to muscarinic receptors, blocks central cholinergic effects, and inhibits cholinergically induced gastrointestinal motility, intestinal smooth muscle contraction, and acetylcholine-mediated neurotransmitter release. Secoverine exerts direct antispasmodic activity on intestinal smooth muscle independent of receptor blockade, and exhibits characteristics such as reversible smooth muscle activity and long duration of action. Secoverine can be used in studies related to hyperintestinal motility, diverticular disease, and colonic spasm.

Ceapin-A7 (Standard) is the analytical standard of Ceapin-A7 (HY-108434). This product is intended for research and analytical applications. Ceapin-A7 is a selective blocker of ATF6α signaling in response to ER stress, with an IC₅₀ of 0.59 μM. Ceapin-A7 can be used to explore both the mechanism of activation of ATF6α and its role in pathological settings.

Ferulic acid methyl ester (Standard) is the analytical standard of Ferulic acid methyl ester (HY-W018643). This product is intended for research and analytical applications. Ferulic acid methyl ester (Methyl ferulate) is a derivative of ferulic acid, isolated from Stemona tuberosa, with anti-inflammatory and antioxidant properties. Ferulic acid methyl ester is a cell membrane and brain permeable compound, shows free radical scavenging ability, used in the research of neurodegenerative disorders. Ferulic acid methyl ester inhibits COX-2 expression, blocks p-p38 and p-JNK in primary bone marrow derived-macrophages.

Ketanserin (tartrate) (Standard) is the analytical standard of Ketanserin (tartrate). This product is intended for research and analytical applications. Ketanserin (R41468) tartrate is a selective 5-HT2 receptor antagonist. Ketanserin tartrate also blocks hERG current (IhERG) in a concentration-dependent manner (IC50=0.11 μM).

Wy 25093 is a selective serotonin (5-HT) uptake transporter inhibitor. Wy 25093 regulates the turnover and metabolism of central 5-HT, enhances postsynaptic 5-HT actions and 5-hydroxytryptophan-induced behavioral syndrome. Wy 25093 induces ipsilateral and contralateral circling behavior in rats, reduces the turnover rate of striatal dopamine, decreases the level of 5-hydroxyindole-3-acetic acid in the brain, and long-term administration reduces brain 5-HT levels. Wy 25093 can be used in research related to depression.

Meglumine cyclic adenylate is a cAMP analog. Meglumine cyclic adenylate promotes STAT3 phosphorylation at Ser727 and mitochondrial translocation. Meglumine cyclic adenylate inhibits cell apoptosis by reducing cytochrome c release and caspase-3 activation. Meglumine cyclic adenylate suppresses the expression of NF-κBp65, activates adenylate cyclase 3, and inhibits phosphodiesterase 4D. Meglumine cyclic adenylate enhances myocardial contractility, increases myocardial Ca²⁺ influx, dilates peripheral blood vessels, improves hypotension and bradycardia, promotes spinal cord function recovery, and regulates fear extinction and anxiety-like behaviors. Meglumine cyclic adenylate can be used in research related to cerebral ischemia/reperfusion injury, systemic inflammatory response syndrome, acute T4 thoracic spinal cord injury, and post-traumatic stress disorder (PTSD).

O-Desethylreboxetine is the major metabolite of Reboxetine (HY-14560), which is catalyzed by the CYP3A4 enzyme. O-Desethylreboxetine can be used in depression-related research.

Atomoxetine (hydrochloride) (Standard) is the analytical standard of Atomoxetine (hydrochloride). This product is intended for research and analytical applications. Atomoxetine (Tomoxetine) hydrochloride is a selective noradrenaline reuptake inhibitor with Ki values of 5 nM, 77 nM and 1451 nM for norepinephrine (NE), serotonin (5-HT) and dopamine (DA) transporters, respectively. Atomoxetine hydrochloride is a potent Na+ channels (VGSCs) blocker. Atomoxetine hydrochloride can be used for attention-deficit hyperactivity disorder (ADHD) research.

β-cyano-L-Alanine (Standard) is the analytical standard of β-cyano-L-Alanine. This product is intended for research and analytical applications. β-cyano-L-Alanine (Beta-cyano-l-alanine), a nitrile of widespread occurrence in higher plants, is enzymatically produced by cyanoalanine synthase from cyanide and cysteine as substrates. β-cyano-L-Alanine abolishes the protective effect of ethanol on cerebral ischemia/reperfusion (I/R) injury.

THIP (Gaboxadol) hydrobromide is a blood-brain barrier-penetrant, orally active selective GABA_A receptor agonist. THIP hydrobromide exhibits EC₅₀ values of 33 μM and 130 μM for α₄β₂δ and α₄β₁δ receptors, respectively. THIP hydrobromide activates extrasynaptic GABA_A receptors to produce tonic inhibition and inhibits GABAergic interneurons to cause disinhibition. THIP hydrobromide is used in research on insomnia, sleep disorders, and addictive behaviors.

Nav1.7-IN-3 (Standard) is the analytical standard of Nav1.7-IN-3 (HY-101789). This product is intended for research and analytical applications. Nav1.7-IN-3 is a selective, orally bioavailable voltage-gated sodium channel Nav1.7 inhibitor with an IC₅₀ of 8 nM. Pain relief. Limited CNS penetration.

GNE-8324 (Standard) is the analytical standard of GNE-8324 (HY-107498). This product is intended for research and analytical applications. GNE-8324 is a selective GluN2A positive allosteric modulator. GNE-8324 selectively enhances NMDA receptor (NMDAR)-mediated synaptic responses in inhibitory but not excitatory neurons.

Dipyanone hydrochloride is structurally similar to known opioids.

Fluvoxamine (Standard) is the analytical standard of Fluvoxamine. This product is intended for research and analytical applications. Fluvoxamine (DU-23000) is an antidepressant which functions pharmacologically as a selective serotonin reuptake inhibitor.

Imipramine-d₆ is the deuterium labeled Imipramine hydrochloride. Imipramine is an orally active tertiary amine tricyclic antidepressant. Imipramine is a Fascin1 inhibitor with antitumor activities. Imipramine also inhibits serotonin transporter with an IC₅₀ value of 32 nM. Imipramine stimulates U-87MG glioma cells autophagy and induces HL-60 cell apoptosis. Imipramine shows neuroprotective and immunomodulatory effects.

1(R),2(S)-epoxy Cannabidiol (Compound 2a) is a structural analogue of phytocannabinoidsphytocannabinoids. 1(R),2(S)-epoxy Cannabidiol exhibits potent inhibitory activity against Wnt/β-catenin pathway. 1(R),2(S)-epoxy Cannabidiol is promising for research of neuroprotective agents.