1. Anti-infection
  2. Bacterial
    Antibiotic
  3. Sutezolid

Sutezolid (Synonyms: PNU-100480; U-100480; PF-02341272)

製品番号: HY-10392 純度: 99.29%
取扱説明書

Sutezolid (PNU-100480), an orally active oxazolidinone antimicrobial agent, acts by inhibiting bacterial protein synthesis. Sutezolid has potent activity against mycobacteria, and is used for the research of drug-resistant tuberculosis.

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Sutezolid 構造式

Sutezolid 構造式

CAS 番号 : 168828-58-8

容量 価格(税別) 在庫状況 数量
無料サンプル (0.5-1 mg)   今すぐ申し込む  
10 mM * 1 mL in DMSO USD 92 在庫あり
Estimated Time of Arrival: December 31
5 mg USD 84 在庫あり
Estimated Time of Arrival: December 31
10 mg USD 144 在庫あり
Estimated Time of Arrival: December 31
25 mg USD 300 在庫あり
Estimated Time of Arrival: December 31
50 mg USD 516 在庫あり
Estimated Time of Arrival: December 31
100 mg USD 936 在庫あり
Estimated Time of Arrival: December 31
200 mg   お問い合わせ  
500 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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Based on 1 publication(s) in Google Scholar

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製品説明

Sutezolid (PNU-100480), an orally active oxazolidinone antimicrobial agent, acts by inhibiting bacterial protein synthesis. Sutezolid has potent activity against mycobacteria, and is used for the research of drug-resistant tuberculosis[1][2].

体外実験

Sutezolid (PNU-100480) exhibits excellent in vitro activity against multiple clinical isolates of Mycobacterium avium complex (MIC’s=0.5-4 µg/mL)[1].

体内実験

Sutezolid (PNU-100480) is a thiomorpholinyl analog of linezolid with superior efficacy against M. tuberculosis in the hollow-fiber, mouse, and whole-blood models[3].

臨床実験
分子量

353.41

分子式

C₁₆H₂₀FN₃O₃S

CAS 番号

168828-58-8

SMILES

O=C(O[[email protected]]1CNC(C)=O)N(C1)C2=CC(F)=C(N3CCSCC3)C=C2

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMSO : 50 mg/mL (141.48 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8296 mL 14.1479 mL 28.2957 mL
5 mM 0.5659 mL 2.8296 mL 5.6591 mL
10 mM 0.2830 mL 1.4148 mL 2.8296 mL
*Please refer to the solubility information to select the appropriate solvent.
体内:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (7.07 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (7.07 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (7.07 mM); Clear solution

*All of the co-solvents are provided by MCE.
参考文献
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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

SutezolidPNU-100480U-100480PF-02341272PNU100480PNU 100480U100480U 100480PF02341272PF 02341272BacterialAntibioticoxazolidinoneantimicrobialbacterialantibioticproteinsynthesistuberculosisInhibitorinhibitorinhibit

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Inquiry Information

製品名:
Sutezolid
製品番号:
HY-10392
数量:
MCE 日本正規代理店: