β-catenin
Beta catenin
β-catenin is a dual function protein, regulating the coordination of cell–cell adhesion and gene transcription. In humans, the CTNNB1 protein is encoded by the CTNNB1 gene. β-catenin is a subunit of the cadherin protein complex and acts as an intracellular signal transducer in the Wnt signaling pathway. It is a member of the catenin protein family and homologous to γ-catenin. Mutations and overexpression of β-catenin are associated with many cancers, including hepatocellular carcinoma, colorectal carcinoma, lung cancer,malignant breast tumors, ovarian and endometrial cancer. β-catenin is regulated and destroyed by the beta-catenin destruction complex, and in particular by the adenomatous polyposis coli (APC) protein, encoded by the tumour-suppressing APC gene. Therefore genetic mutation of the APC gene is also strongly linked to cancers, and in particular colorectal cancer resulting from familial adenomatous polyposis (FAP).
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β-catenin Inhibitors
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β-catenin Agonists
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β-catenin Antagonists
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β-catenin Activators
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β-catenin Modulators
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β-catenin Inducer
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β-catenin Degraders
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β-catenin Related Products (353)
Related Products (353)
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Antibodies (10)
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Nefopam-d3
0 ImagesCat. No.: HY-B1057S2CAS No.: 1346747-15-6Synonyms: Fenazoxine-d3Nefopam-d3 is a deuterium labeled Nefopam (Fenazoxine). Nefopam is a centrally-acting but non-opioid analgesic drug, and Nefopam targets β-catenin protein level in mesenchymal cells.
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Erlotinib-13C6
0 ImagesCat. No.: HY-50896S1CAS No.: 1211107-68-4Synonyms: CP-358774-13C6; NSC 718781-13C6; OSI-774-13C6Erlotinib-13C6 (CP-358774-13C6) is the 13C-labeled Erlotinib (HY-50896). Erlotinib (CP-358774) is a selective, orally active EGFR tyrosine kinase inhibitor. Erlotinib also acts as a substrate and inhibitor of OATP2B1, with an IC50 of approximately 0.079 μM for inhibiting OATP2B1-mediated uptake of estrone 3-sulfate. Erlotinib blocks EGFR phosphorylation, downstream signal transduction, as well as the growth and proliferation of cancer cells. Erlotinib inhibits MMP-10-mediated renal injury, fibrotic lesions, the ERK1/2, GSK-3β and β-catenin signaling pathways, fibronectin, α-SMA, collagen deposition, and renal injury markers. Erlotinib is metabolized via CYP3A to produce the active metabolite OSI-420. Erlotinib can be used in research related to non-small cell lung cancer, gastric cancer, papillary renal cell carcinoma, pancreatic cancer, renal fibrosis, and other conditions.
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Tizanidine-d4 hydrochloride
0 ImagesCat. No.: HY-B0194ASCAS No.: 1188263-51-5Tizanidine-d4 hydrochloride is deuterium labeled Tizanidine hydrochloride (HY-B0194A). Tizanidine hydrochloride, a skeletal muscle relaxant, is an orally effective central α2-adrenoceptor agonist (IC50 = 6.9 nmol). Tizanidine hydrochloride primarily exerts muscle relaxation effects by inhibiting the release of excitatory amino acids (glutamate and aspartate) from the presynaptic terminals of spinal cord interneurons. Tizanidine hydrochloride has anti-injury activity and can inhibit gastrointestinal (GI) transport. Tizanidine hydrochloride can inhibit the proliferation, migration, and invasion of lung cancer cells and induce cell apoptosis by upregulating Nischarin and inhibiting the AKT and Wnt3a/β-catenin signaling pathways. Tizanidine hydrochloride can be used to treat spasticity caused by diseases such as multiple sclerosis (MS), stroke, and spinal cord injury (SCI).
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ALOX5 stabilizer-1
0 ImagesCat. No.: HY-175634ALOX5 stabilizer-1 is an arachidonate 5-lipoxygenase (ALOX5) stabilizer with a Kd of 7.26 μM. ALOX5 stabilizer-1 inhibits β-catenin protein levels and then suppresses STAT3 signal pathway. ALOX5 stabilizer-1 induces lung cancer cells apoptosis, inhibited cell migration and proliferation. ALOX5 stabilizer-1 can used for the study of non-small cell lung cancer (NSCLC).
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Nefopam hydrochloride (Standard)
0 ImagesSynonyms: Fenazoxine hydrochloride (Standard)Nefopam (hydrochloride) (Standard) is the analytical standard of Nefopam (hydrochloride). This product is intended for research and analytical applications. Nefopam hydrochloride (Fenazoxine hydrochloride) is a centrally-acting but non-opioid analgesic drug, for the relief of moderate to severe pain. Nefopam hydrochloride targets β-catenin protein level in mesenchymal cells in-vitro and in-vivo.
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1(R),2(S)-epoxy Cannabidiol
0 ImagesCat. No.: HY-168364CAS No.: 2345666-26-21(R),2(S)-epoxy Cannabidiol (Compound 2a) is a structural analogue of phytocannabinoidsphytocannabinoids. 1(R),2(S)-epoxy Cannabidiol exhibits potent inhibitory activity against Wnt/β-catenin pathway. 1(R),2(S)-epoxy Cannabidiol is promising for research of neuroprotective agents.
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XAV-939 (Standard)
0 ImagesXAV-939 (Standard) is the analytical standard of XAV-939. This product is intended for research and analytical applications. XAV-939 is a Tankyrase inhibitor. XAV-939 has inhibitory activity for TNKS1 and TNKS2 with IC50 values of 5 nM and 2 nM, respectively. XAV-939 also is an enhancer of osteoblastic differentiation of hMSCs. XAV-939 can be used for the research of conditions associated with activated Wnt signaling, such as cancer, fibrotic diseases and conditions associated with low bone formation.
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Acremonamide
0 ImagesCat. No.: HY-N15490CAS No.: 2855099-87-3Acremonamide is a cyclic pentapeptide lactone discovered from the marine-derived Acremonium strain CNQ-049, possessing wound healing activity. Acremonamide upregulates the expression of COL1A2 and ACTC1 genes and enhances the motility of keratinocytes and fibroblasts. Acremonamide promotes wound healing in mouse skin wound models. Acremonamide can be used in research related to skin wound healing.
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WHN-88
0 ImagesCat. No.: HY-164547CAS No.: 2490686-86-5
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Chlorquinaldol (Standard)
0 ImagesChlorquinaldol (Standard) is the analytical standard of Chlorquinaldol. This product is intended for research and analytical applications. Chlorquinaldol (Chloquinan) is an antibacterial agent with the potential use in topical skin conditions and vaginal infections. Chlorquinaldol is a β-catenin/TCF4 inhibitor, showing anti-proliferation, anti-migration, and apoptosis-inducing activity in cancer cells.
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ICG-001 (Standard)
0 ImagesCat. No.: HY-14428RCAS No.: 780757-88-2ICG-001 (Standard) is the analytical standard of ICG-001 (HY-14428). This product is intended for research and analytical applications. ICG-001 is an inhibitor of β-catenin/TCF mediated transcription. ICG-001 works by specifically binding to cyclic AMP response element-binding protein with an IC50 of 3 μM. ICG-001 selectively blocks the β-catenin/CBP interaction without interfering with the β-catenin/p300 interaction.
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Murayaquinone
0 ImagesCat. No.: HY-133093CAS No.: 100843-91-2Synonyms: PKF118-774Murayaquinone (PKF118-774) is a β-catenin/Tcf4 complex inhibitor with an IC50 of 2.4 μM. Murayaquinone is a nematicidal agent found in Streptomyces sp. AN140557.
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NRX-252262 (Standard)
0 ImagesCat. No.: HY-111760RCAS No.: 2438637-61-5NRX-252262 (Standard) is the analytical standard of NRX-252262 (HY-111760). This product is intended for research and analytical applications. NRX-252262 is a potent enhancer of the interaction between β-Catenin, and its cognate E3 ligase, SCFβ-TrCP, induces mutant β-catenin degradation, with an EC50 of 3.8 nM.
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β-catenin-IN-6 (Standard)
0 ImagesCat. No.: HY-10834RCAS No.: 1039731-99-1β-catenin-IN-6 (Standard) is the analytical standard of β-catenin-IN-6 (HY-10834). This product is intended for research and analytical applications. β-catenin-IN-6 is a β-catenin inhibitor, targeting to canonical Wingless-related integration site signaling pathway. β-catenin-IN-6 inhibits human colorectal cancer cells proliferation, as well as in a β-catenin/RK3E mouse model.
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Sempervirine nitrate
0 ImagesCat. No.: HY-N7507ACAS No.: 17994-15-9Sempervirine is an alkaloid derived from Gelsemium elegans Benth.. Sempervirine inhibits the proliferation of hepatocellular carcinoma (HCC) cells and induces apoptosis by regulating Wnt/β-catenin pathway.
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Tizanidine (Standard)
0 ImagesCat. No.: HY-B0194RCAS No.: 51322-75-9Tizanidine (Standard) is the analytical standard of Tizanidine (HY-B0194). This product is intended for research and analytical applications. Tizanidine, a skeletal muscle relaxant, is an orally effective central α2-adrenoceptor agonist (IC50 = 6.9 nmol). Tizanidine primarily exerts muscle relaxation effects by inhibiting the release of excitatory amino acids (glutamate and aspartate) from the presynaptic terminals of spinal cord interneurons. Tizanidine has anti-injury activity and can inhibit gastrointestinal (GI) transport. Tizanidine can inhibit the proliferation, migration, and invasion of lung cancer cells and induce cell apoptosis by upregulating Nischarin and inhibiting the AKT and Wnt3a/β-catenin signaling pathways. Tizanidine can be used to treat spasticity caused by diseases such as multiple sclerosis (MS), stroke, and spinal cord injury (SCI).
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LZZ-02
0 ImagesCat. No.: HY-183474CAS No.: 37418-69-2Synonyms: ZINC13406363LZZ-02 (ZINC13406363) is an orally active Tankyrase 1/2 inhibitor. LZZ-02 reduces c-Myc levels and inhibits the transcriptional activity of the WNT/β-catenin pathway. LZZ-02 exhibits anticancer activity against colon cancer. LZZ-02 can be used in studies related to colorectal cancer.
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Bozepinib
0 ImagesCat. No.: HY-118032CAS No.: 1207993-83-6Bozepinib is an anticancer agent. Bozepinib induces Apoptosis, and inhibits the HER-2 signaling pathway as well as JNK and ERK kinases. Bozepinib induces the down-regulation of c-MYC, β-catenin and SOX2 proteins, and the up-regulation of GLI-3. Bozepinib can be used in the research of breast cancer and colon cancer.
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MSAB (Standard)
0 ImagesCat. No.: HY-120697RCAS No.: 173436-66-3MSAB (Standard) is the analytical standard of MSAB (HY-120697). This product is intended for research and analytical applications. MSAB is a potent and selective inhibitor of Wnt/β-catenin signaling. MSAB binds to β-catenin and promotes its degradation, and specifically downregulates Wnt/β-catenin target genes. MSAB exhibits potent anti-tumor effects selectively on Wnt-dependent cancer cells.
