2. Signaling Pathways
  3. Protein Tyrosine Kinase/RTK
  4. Anaplastic lymphoma kinase (ALK)
  5. Anaplastic lymphoma kinase (ALK) Ligand

Anaplastic lymphoma kinase (ALK) Ligand

Anaplastic lymphoma kinase (ALK) Ligands (6):

Cat. No. Product Name Effect Purity
  • HY-156569
    DGKα-IN-2
    		Ligand 98.83%
    DGKα-IN-2 (example 48) is a DGKα inhibitor with the IC50 of 0.9 nM, extracted from patent WO2021105115. DGKα-IN-2 significantly enhances the anti-tumor effect of anti-PD-1 by increasing the proliferation and function of T cells. DGKα-IN-2 has the potential for cancer and immunology study.
  • HY-150908
    Brigatinib A
    		Ligand
    Brigatinib A is an GID4 ligand. Brigatinib A can be used for synthesizing PROTAC BCR-ABL Degrader-2 (HY-174368).
  • HY-183441
    ALK5 ligand-1
    		Ligand
    ALK5 ligand-1 (a31's ALK5 ligand) is a ligand of Anaplastic lymphoma kinase ALK5 with higher selectivity for ALK5 than for ALK4. ALK5 ligand-1 can be used to synthesize PROTAC degraders targeting ALK5. ALK5 PROTACs induce ALK5 degradation dependent on the ubiquitin-proteasome system and exert antifibrotic activity. ALK5 ligand-1 can be used in studies of pulmonary fibrosis.
  • HY-180971
    Ceritinib-amide-C3-acid
    		Ligand
    Ceritinib-amide-C3-acid is a target protein ligand-linker conjugate. Ceritinib-amide-C3-acid incorporates a protein ligand Ceritinib (HY-15656) and a link for E3 ligases ligand. Ceritinib-amide-C3-acid can be used for the synthesis of TD-004 (HY-180970).
  • HY-W754809
    ALK ligand-1
    		Ligand
    ALK ligand-1 is a ALK ligand that can be used for synthesis of PROTAC ALK degrader-4 (HY-175527).
  • HY-183442
    ALK5 ligand-1-amine-C2-piperazine-C4-OH
    		Ligand
    ALK5 ligand-1-amine-C2-piperazine-C4-OH is a conjugate of a ligand targeting ALK5 and a PROTAC linker. ALK5 ligand-1-amine-C2-piperazine-C4-OH can be used to synthesize the PROTAC degrader (a31). ALK5 PROTACs induce UPS-dependent and selective degradation of ALK5 over ALK4. ALK5 ligand-1-amine-C2-piperazine-C4-OH can be applied to research on pulmonary fibrosis.