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ATM/ATR Related Products (60)
Related Products (60)
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ZH25
0 ImagesCat. No.: HY-184294CAS No.: 3037598-39-0ZH25 is an ATR kinase inhibitor with antiproliferative activity against ATM-deficient cancer cells. ZH25 induces DNA damage, reduces G2/M phase cell proportion, upregulates γH2AX, Cleaved-Caspase3, and Cleaved-PARP. ZH25 functions as an ATR kinase binding ligand for ATR-PROTAC degrader design. ZH25 can be used for the research of atm-deficient cancer.
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ATR-IN-5
0 ImagesCat. No.: HY-142671CAS No.: 2601571-19-9ATR-IN-5 is a potent inhibitor of ATR. ATR is a class of protein kinases involved in genome stability and DNA damage repair, and is a member of the PIKK family. ATR-IN-5 has the potential for the research of ATR kinase-mediated diseases such as proliferative diseases and cancer (extracted from patent CN112047938A, compound D24).
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Berzosertib (Standard)
0 ImagesCat. No.: HY-13902RCAS No.: 1232416-25-9Synonyms: VE-822 (Standard); VX-970 (Standard); M6620 (Standard)Berzosertib (Standard) is the analytical standard of Berzosertib (HY-13902). This product is intended for research and analytical applications. Berzosertib (VE-822) is an orally active, CNS-penetrant, and selective ATR Kinase inhibitor. Berzosertib blocks ATR Kinase activity, abrogates G2/M cell cycle checkpoint, impairs DNA damage repair. Berzosertib induces apoptosis, inhibnits conlony migration, inhibits cell proliferation, and activates cGAS-STING axes in cancer cells. Berzosertib can be used for the research of cancers, such as head and neck squamous cell carcinoma, and colorectal cancer.
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Decarbamoylmitomycin C
0 ImagesCat. No.: HY-167635CAS No.: 26909-37-5Decarbamoylmitomycin C, an analog of Mitomycin C (MC), is an DNA-alkylating agent. Decarbamoylmitomycin C (DMC) activates p53-independent ataxia telangiectasia and rad3 related protein (ATR) chromatin eviction.
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Elimusertib (Standard)
0 ImagesSynonyms: BAY 1895344 (Standard)Elimusertib (Standard) is the analytical standard of Elimusertib (HY-101566). This product is intended for research and analytical applications. Elimusertib (BAY-1895344) is a potent, orally active and selective ATR inhibitor with an IC50 of 7 nM. Elimusertib has anti-tumor activity. Elimusertib can be used for the research of solid tumors and lymphomas.
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AZD0156 (Standard)
0 ImagesCat. No.: HY-100016RCAS No.: 1821428-35-6AZD0156 (Standard) is the analytical standard of AZD0156 (HY-100016). This product is intended for research and analytical applications. AZD0156 is a potent, selective and orally active ATM inhibitor with an IC50 of 0.58 nM. AZD0156 inhibits the ATM-mediated signaling, prevents DNA damage checkpoint activation, disrupts DNA damage repair, and induces tumor cell apoptosis.
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Ro 90-7501 (Standard)
0 ImagesCat. No.: HY-103241RCAS No.: 293762-45-5Ro 90-7501 (Standard) is the analytical standard of Ro 90-7501 (HY-103241). This product is intended for research and analytical applications. Ro 90-7501 is an amyloid β42 (Aβ42) fibril assembly inhibitor that reduces Aβ42-induced cytotoxicity (EC50 of 2 μM). Ro 90-7501 inhibits ATM phosphorylation and DNA repair. RO 90-7501 selectively enhances toll-like receptor 3 (TLR3) and RIG-I-like receptor (RLR) ligand-induced IFN-β gene expression and antiviral response. Ro 90-7501 also inhibits protein phosphatase 5 (PP5) in a TPR-dependent manner. Ro 90-7501 has significant radiosensitizing effects on cervical cancer cells.
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AZD-7648 (Standard)
0 ImagesCat. No.: HY-111783RCAS No.: 2230820-11-6
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Gavapsertib
0 ImagesCat. No.: HY-181618CAS No.: 2758113-98-1Gavapsertib (compound A) is a ATR kinase inhibitor that can be used in tumor research.
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Ceralasertib formate
0 ImagesCat. No.: HY-123502CAS No.: 1352280-98-8Synonyms: AZD-6738 formateCeralasertib formate is a potent, selective and orally active ATR inhibitor with an IC50 value of 1 nM. Ceralasertib formate inhibits cell viability and induces DNA damage. Ceralasertib formate induces cell senescence. Ceralasertib formate shows antitumor activity.
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Ceralasertib (Standard)
0 ImagesCat. No.: HY-19323RCAS No.: 1352226-88-0Synonyms: AZD6738 (Standard)Ceralasertib (Standard) is the analytical standard of Ceralasertib (HY-19323). This product is intended for research and analytical applications. Ceralasertib (AZD6738) is an orally active and bioavailable inhibitor of ATR Kinase with an IC50 of 1 nM.
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KU-55933 (Standard)
0 ImagesCat. No.: HY-12016RCAS No.: 587871-26-9KU-55933 (Standard) is the analytical standard of KU-55933 (HY-12016). This product is intended for research and analytical applications. KU-55933 is a potent ATM inhibitor with an IC50 and Ki of 12.9 and 2.2 nM, respectively, and is highly selective for ATM as compared to DNA-PK, PI3K/PI4K, ATR and mTOR.
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CP-466722 (Standard)
0 ImagesCat. No.: HY-11002RCAS No.: 1080622-86-1CP-466722 (Standard) is the analytical standard of CP-466722 (HY-11002). This product is intended for research and analytical applications. CP-466722 is a rapidly reversible inhibitor of ATM, with an IC50 of 0.41 μM, and has no effects on PI3K or closely related PI3K-like protein Kinase (PIKK) family members.
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Tuvusertib (Standard)
0 ImagesCat. No.: HY-111451RCAS No.: 1613200-51-3Synonyms: M1774 (Standard); ATR inhibitor 1 (Standard)Tuvusertib (Standard) is the analytical standard of Tuvusertib (HY-111451). This product is intended for research and analytical applications. Tuvusertib (M1774; ATR inhibitor 1) is a selective and orally active ATR inhibitor extracted from patent WO2015187451A1, compound I-l, with a Ki value below 1 μΜ.
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Tuvusertib-d3
0 ImagesCat. No.: HY-111451SSynonyms: M1774-d3; ATR inhibitor 1-d3Tuvusertib-d3 (M1774-d3) is the deuterium labeled Tuvusertib (HY-111451). Tuvusertib (M1774; ATR inhibitor 1) is a selective and orally active ATR inhibitor with a Ki value below 1 μΜ.
